{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:54:35Z","timestamp":1787169275089,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T00:00:00Z","timestamp":1529712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009550","name":"Hasselt University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001835","name":"Maastricht University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Aims: Exercise combined with adipose tissue lipolytic inhibition augments intramuscular lipid and glycogen use in type 2 diabetes patients. The present study investigates the impact of adipose tissue lipolytic inhibition during exercise on subsequent postprandial glycemic control in type 2 diabetes patients.<\/jats:p>\n                  <jats:p>\n                    Methods: Fourteen male type 2 diabetes patients (age 65 \u00b1 2 years, HbA\n                    <jats:sub>1c<\/jats:sub>\n                    6.7 \u00b1 0.1% (50 \u00b1 2\u2005mmol\/mol)) participated in a double\u2010blind placebo\u2010controlled randomized cross\u2010over study in which subjects performed endurance\u2010type exercise after being administered 250\u2005mg of a nicotinic acid analogue (acipimox; ACP) or a placebo (PLA). A control experiment was included in which no exercise was performed (CON).\n                  <\/jats:p>\n                  <jats:p>\n                    Results: Sixty minutes of endurance\u2010type exercise (at 45%\n                    <jats:italic>W<\/jats:italic>\n                    <jats:sub>peak)<\/jats:sub>\n                    did not significantly lower circulating plasma glucose and insulin excursions in PLA when compared with CON (\n                    <jats:italic>P<\/jats:italic>\n                    = .300). Acipimox administration strongly reduced circulating plasma FFA concentrations during exercise (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001). Circulating plasma glucose and insulin excursions were substantially lower during 7.5\u2005h of recovery from exercise (\n                    <jats:italic>i.e.<\/jats:italic>\n                    postprandial) in ACP when compared with either CON (\n                    <jats:italic>P<\/jats:italic>\n                    = .041 and\n                    <jats:italic>P<\/jats:italic>\n                    = .002, respectively) or PLA (\n                    <jats:italic>P<\/jats:italic>\n                    = .009 and\n                    <jats:italic>P<\/jats:italic>\n                    = .001, respectively).\n                  <\/jats:p>\n                  <jats:p>Conclusions: Collectively, exercise with adipose tissue lipolytic inhibition reduces postprandial blood glucose and insulin excursions and, as such, further improves glycemic control in male type 2 diabetes patients.<\/jats:p>","DOI":"10.1080\/17461391.2018.1483428","type":"journal-article","created":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T06:04:10Z","timestamp":1529733850000},"page":"1245-1254","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["Adipose tissue lipolytic inhibition enhances the glucoregulatory properties of exercise in type 2 diabetes patients"],"prefix":"10.1002","volume":"18","author":[{"given":"Dominique","family":"Hansen","sequence":"first","affiliation":[{"name":"REVAL \u2013 Rehabilitation Research Center BIOMED \u2013 Biomedical Research Center Faculty of Medicine and Life Sciences Hasselt University Diepenbeek Belgium"},{"name":"Jessa Hospital, Heart Centre Hasselt Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Verboven","sequence":"additional","affiliation":[{"name":"REVAL \u2013 Rehabilitation Research Center BIOMED \u2013 Biomedical Research Center Faculty of Medicine and Life Sciences Hasselt University Diepenbeek Belgium"},{"name":"Department of Human Biology and Movement Sciences NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre+ Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Willem","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Institute of Sports and Exercise Studies HAN University of Applied Sciences Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Zorenc","sequence":"additional","affiliation":[{"name":"Department of Human Biology and Movement Sciences NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre+ Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennert","family":"Minten","sequence":"additional","affiliation":[{"name":"REVAL \u2013 Rehabilitation Research Center BIOMED \u2013 Biomedical Research Center Faculty of Medicine and Life Sciences Hasselt University Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Smeets","sequence":"additional","affiliation":[{"name":"REVAL \u2013 Rehabilitation Research Center BIOMED \u2013 Biomedical Research Center Faculty of Medicine and Life Sciences Hasselt University Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lex B.","family":"Verdijk","sequence":"additional","affiliation":[{"name":"Department of Human Biology and Movement Sciences NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre+ Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc J. 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