{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:53:02Z","timestamp":1793055182963,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of the present study was to evaluate the influence of exercise\u2010induced hypoxemia (EIH) on muscle and cerebral oxygenation responses during maximal exercise in normoxia and in acute moderate hypoxia (fraction of inspired oxygen: 15.3%, 2400\u2005m). EIH was defined as a drop in hemoglobin saturation of at least 4% for at least three consecutive minutes during maximal exercise at sea level. Twenty\u2010five athletes performed incremental treadmill tests to assess maximal oxygen consumption (VO<jats:sub>2max<\/jats:sub>) in normoxia and in hypoxia. Oxygenation of the vastus lateralis muscle and the left prefrontal cortex of the brain was monitored using near\u2010infrared spectroscopy. During the normoxic test, 15 athletes exhibited EIH; they displayed a larger change in muscle levels of oxyhemoglobin (\u0394O<jats:sub>2<\/jats:sub>Hb) (<jats:italic>p<\/jats:italic> = 0.04) and a greater change in cerebral levels of deoxyhemoglobin (\u0394HHb) (<jats:italic>p<\/jats:italic> = 0.02) than athletes without EIH (NEIH group). During the hypoxic test, muscle \u0394O<jats:sub>2<\/jats:sub>Hb was lower in the EIH group than in the NEIH group (<jats:italic>p<\/jats:italic> = 0.03). At VO<jats:sub>2max<\/jats:sub>, hypoxia was associated with a smaller cerebral \u0394O<jats:sub>2<\/jats:sub>Hb in both groups, and a greater cerebral \u0394HHb compared to normoxia in the NEIH group only (<jats:italic>p<\/jats:italic> = 0.02). No intergroup differences in changes in muscle oxygenation were observed. The severity of O<jats:sub>2<\/jats:sub> arterial desaturation was negatively correlated with changes in total muscle hemoglobin in normoxia (<jats:italic>r<\/jats:italic> = \u22120.48, <jats:italic>p<\/jats:italic> = 0.01), and positively correlated with the cerebral \u0394HHb in normoxia (<jats:italic>r<\/jats:italic> = 0.45, <jats:italic>p<\/jats:italic> = 0.02). The occurrence of EIH at sea level was associated with specific muscle and cerebral oxygenation responses to exercise under both normoxia and moderate hypoxia.<\/jats:p>","DOI":"10.1080\/17461391.2019.1669717","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T14:17:20Z","timestamp":1568729840000},"page":"803-812","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Muscle and cerebral oxygenation during exercise in athletes with exercise\u2010induced hypoxemia: A comparison between sea level and acute moderate hypoxia"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5032-8301","authenticated-orcid":false,"given":"Antoine","family":"Raberin","sequence":"first","affiliation":[{"name":"LEPSA, EA 4604, Universit\u00e9 de Perpignan Via Domitia Font Romeu France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-2461","authenticated-orcid":false,"given":"Henri","family":"Meric","sequence":"additional","affiliation":[{"name":"LEPSA, EA 4604, Universit\u00e9 de Perpignan Via Domitia Font Romeu France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-1600","authenticated-orcid":false,"given":"Patrick","family":"Mucci","sequence":"additional","affiliation":[{"name":"Univ. 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