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Sixteen moderately\u2010trained males ingested 5\u2005g\/d of FO (<jats:italic>n<\/jats:italic>\u2009=\u20098) or soybean oil (placebo) capsules (<jats:italic>n<\/jats:italic>\u2009=\u20098) for 4\u2010wk prior to\u2010 and 3\u2010d following an acute eccentric exercise bout. Eccentric exercise consisted of 12 sets of isokinetic knee extension and knee flexion. Indices of muscle damage, soreness, function and inflammation were measured at baseline and during exercise recovery. Eccentric exercise elicited an increase in muscle soreness (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.010) and thigh volume (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and reduced peak isometric torque by 31.7\u2009\u00b1\u20096.9%, (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, 95% CI 10.6\u201352.8) during 3\u2010d of recovery. Blood omega\u20103 polyunsaturated fatty acid concentration was 14.9\u2009\u00b1\u20092.4% higher in FO than PLA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, 95% CI 9.8\u201320.1). However, FO did not ameliorate the cumulative creatine kinase response (expressed as AUC; <jats:italic>p<\/jats:italic>\u2009=\u20090.368), inflammation (<jats:italic>p<\/jats:italic>\u2009=\u20090.400), muscle soreness (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.140), or muscle function (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.249) following eccentric exercise. FO supplementation confers no clear benefit in terms of ameliorating the degree of muscle damage, or facilitating the muscle repair process, during acute eccentric exercise recovery. These data suggest that FO supplementation does not provide an effective nutritional strategy to promote exercise recovery, at least in moderately\u2010trained young men.<\/jats:p><jats:p><jats:bold>Abbreviations:<\/jats:bold> ANOVA: Analysis of variance; AUC: Area under curve; CI: Confidence interval; CK: Creatine kinase; CMJ: Countermovement jump; COX: Cyclooxygenase; CRP: C\u2010reactive protein; DHA: Docosahexaenoic acid; DOMS: Delayed\u2010onset muscle soreness; EIMD: Exercise\u2010induced muscle damage; En%: Energy percent; EPA: Eicosapentaenoic acid; FO: Fish oil; IL\u20106: Interleukin\u20106; LDH: Lactate dehydrogenase; LOX: Lipoxygenase; Mb: Myoglobin; mTOR: Mechanistic target of rapamycin; PLA: Placebo; ROM: Range of motion; ROS: Reactive oxygen species; SD: Standard deviation; SEM: Standard error of the mean; TNF\u2010\u03b1: Tumour necrosis factor alpha; VAS: Visual analogue scale; \u03a93\u2010PUFA: Omega\u20103 polyunsaturated fatty acids; \u03a96\u2010PUFA: Omega\u20106 polyunsaturated fatty acids<\/jats:p>","DOI":"10.1080\/17461391.2023.2199282","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T11:29:47Z","timestamp":1680521387000},"page":"1666-1676","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":13,"title":["Fish oil supplementation fails to modulate indices of muscle damage and muscle repair during acute recovery from eccentric exercise in trained young males"],"prefix":"10.1002","volume":"23","author":[{"given":"Janna","family":"Mackay","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences and Sport University of Stirling Stirling UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bowles","sequence":"additional","affiliation":[{"name":"Centre of Human &amp; Applied Physiological Research King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-6468","authenticated-orcid":false,"given":"Lewis J.","family":"Macgregor","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Sport University of Stirling Stirling UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Prokopidis","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Biology Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Campbell","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Sport University of Stirling Stirling UK"},{"name":"Department of Clinical Neurosciences Division of Physical Medicine and Rehabilitation University of Calgary Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloise","family":"Barber","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Sport University of Stirling Stirling UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart D. 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