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The purpose of this investigation was to examine the effects of 75\u2010repetition (BFR\u201075) (1\u2009\u00d7\u200930, 3\u2009\u00d7\u200915) and 4 sets to failure (BFR\u20104x) protocols on indices of EIMD among untrained women. Thirteen women completed this investigation. One leg was randomly assigned to BFR\u201075 and the other to BFR\u20104x. Each leg performed isokinetic, unilateral, concentric\u2010eccentric, leg extension muscle actions at 30% of maximal strength. Indices of EIMD (muscle soreness, range of motion [ROM], limb circumference, pain pressure threshold [PPT], and maximal voluntary isometric contraction [MVIC]) were recorded before exercise, 0\u2010, 24\u2010, 48\u2010, 72\u2010, and 96\u2010hours post\u2010exercise. There were no changes for ROM, circumference, or PPT. Muscle soreness increased similarly in both conditions 0\u2010, 24\u2010, and 48\u2010hours post\u2010exercise and MVIC increased 24\u2010, 48\u2010, 72\u2010, and 96\u2010hours post\u2010exercise. These findings suggested BFR\u201075 and BFR\u20104x were not associated with EIMD and elicited similar physiological responses. The increases in muscle soreness may be due to metabolic stress associated with LL\u2009+\u2009BFR protocols apart from EIMD.<\/jats:p>","DOI":"10.1080\/17461391.2023.2201813","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T05:04:40Z","timestamp":1681103080000},"page":"1993-2001","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["75\u2010repetition versus sets to failure of blood flow restriction exercise on indices of muscle damage in women"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-7245","authenticated-orcid":false,"given":"Christopher E.","family":"Proppe","sequence":"first","affiliation":[{"name":"School of Kinesiology and Physical Therapy University of Central Florida Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor 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