{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:57:38Z","timestamp":1787007458699,"version":"build-2736575974"},"reference-count":140,"publisher":"Informa UK Limited","issue":"7","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL157975-01A1"],"award-info":[{"award-number":["HL157975-01A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Hematology"],"published-print":{"date-parts":[[2024,7,2]]},"DOI":"10.1080\/17474086.2024.2356763","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T08:56:40Z","timestamp":1715849800000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Novel mechanisms of action of emerging therapies of hereditary thrombotic thrombocytopenic purpura"],"prefix":"10.1080","volume":"17","author":[{"given":"X. Long","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine and Institute of Reproductive Medicine and Developmental Sciences, the University of Kansas Medical Center, Kansas, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172277399"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982558"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2264-7"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15010"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005760"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35097008"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100515200"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.154311"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112064"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0025-6196(12)60522-9"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.10.4223.bloodjournal87104223"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801735105"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.09.004"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.131227"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7933.2004.00623.x"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21143"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1401"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051732"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212023072306"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080130"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.229609"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04094.x"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.535963"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.01941.x"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0496-6"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3796"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-08717-7_5"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04341.x"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-403113"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(98)80064-4"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200309000-00003"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07515.x"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408914"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-13-04-0025"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02452-0"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.15"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-007252"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010086"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001040"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15006"},{"key":"e_1_3_4_43_1","first-page":"21","article-title":"Hyaline thrombosis of the terminal arterioles and capillaries: a hitherto undescribed disease","volume":"24","author":"Moschcowitz E","year":"1924","unstructured":"Moschcowitz E. Hyaline thrombosis of the terminal arterioles and capillaries: a hitherto undescribed disease. Proc N Y Pathol Soc. 1924;24:21\u201324.","journal-title":"Proc N Y Pathol Soc"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.9.3097"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392202"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.10.4235.bloodjournal87104235"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392203"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250605"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250604"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-4035"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1662"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1654"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.12.018"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04183.x"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00841.x"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1796"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1346"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0715"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-05-0236"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20267"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-12-0817"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20137836.2006.02098.x"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-01-0059"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0986-8"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.09.007"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-254193"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20137836.2011.04399.x"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24159"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24594"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0152"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01959.x"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-002139"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-083329"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903679106"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170905"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14962"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-173021"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.223"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311407"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1043\/1543-2165(2003)127<834:TTPAHU>2.0.CO;2"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13186"},{"key":"e_1_3_4_82_1","first-page":"1233","article-title":"ABO incompatibility and neonatal hyperbilirubinemia","volume":"84","author":"Chen SH","year":"1985","unstructured":"Chen SH, Lin KS, Chen CL. ABO incompatibility and neonatal hyperbilirubinemia. Taiwan Yi Xue Hui Za Zhi. 1985;84:1233\u20131239.","journal-title":"Taiwan Yi Xue Hui Za Zhi"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02808.x"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.2706"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-553131"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000215994.25958.31"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12494"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2016.04.009"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1813013"},{"key":"e_1_3_4_90_1","first-page":"508","article-title":"Inherited thrombotic thrombocytopenic purpura in pregnancy","volume":"34","author":"Drews K","year":"2013","unstructured":"Drews K, Seremak-Mrozikiewicz A, Sobieszczyk S, et al. Inherited thrombotic thrombocytopenic purpura in pregnancy. Neuro Endocrinol Lett. 2013;34:508\u2013513.","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15009"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000959"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23249"},{"key":"e_1_3_4_94_1","first-page":"336","article-title":"Minor stroke as singular manifestation of hereditary thrombotic thrombocytopenic purpura in a young man","volume":"28","author":"Lindblom A","year":"2009","unstructured":"Lindblom A, Thorsen S, Hillarp A, et al. Minor stroke as singular manifestation of hereditary thrombotic thrombocytopenic purpura in a young man. Int Angiol. 2009;28:336\u2013339.","journal-title":"Int Angiol"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-884700"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614408"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009801"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03809.x"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06264.x"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14891"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23527"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.390690"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04224.x"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305331200"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505513200"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788026"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-188996"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2314793"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13663"},{"key":"e_1_3_4_110_1","unstructured":"Pflaum CK. FDA approves first treatment for patients with rare inherited blood clotting disorder. 2023. Available from: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-treatment-patients-rare-inherited-blood-clotting-disorder"},{"key":"e_1_3_4_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2210781"},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-02-0069"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-08-0520"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02232.x"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23106"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.235549"},{"key":"e_1_3_4_117_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2019.55.6.2989843"},{"key":"e_1_3_4_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103722"},{"key":"e_1_3_4_119_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007599"},{"key":"e_1_3_4_120_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001973"},{"key":"e_1_3_4_121_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806311"},{"key":"e_1_3_4_122_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505533"},{"key":"e_1_3_4_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15406"},{"key":"e_1_3_4_124_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000001522"},{"key":"e_1_3_4_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18915"},{"key":"e_1_3_4_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18888"},{"key":"e_1_3_4_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17833"},{"key":"e_1_3_4_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04740-4"},{"key":"e_1_3_4_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-021-00992-5"},{"key":"e_1_3_4_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27737"},{"key":"e_1_3_4_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26693"},{"key":"e_1_3_4_132_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2253-9359"},{"key":"e_1_3_4_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-010-0387-5"},{"key":"e_1_3_4_134_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61852"},{"key":"e_1_3_4_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2024.101205"},{"key":"e_1_3_4_136_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115665232279893231228065540"},{"key":"e_1_3_4_137_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-486779"},{"key":"e_1_3_4_138_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2021.2021151"},{"key":"e_1_3_4_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2009.98"},{"key":"e_1_3_4_140_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.308680"},{"key":"e_1_3_4_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26298-4"},{"key":"e_1_3_4_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3648-x"}],"container-title":["Expert Review of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17474086.2024.2356763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T14:42:20Z","timestamp":1719412940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17474086.2024.2356763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":140,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7,2]]}},"alternative-id":["10.1080\/17474086.2024.2356763"],"URL":"https:\/\/doi.org\/10.1080\/17474086.2024.2356763","relation":{},"ISSN":["1747-4086","1747-4094"],"issn-type":[{"value":"1747-4086","type":"print"},{"value":"1747-4094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierr20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierr20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}