{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:32:05Z","timestamp":1792661525878,"version":"4.5.0"},"reference-count":165,"publisher":"Informa UK Limited","issue":"8","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Respiratory Medicine"],"published-print":{"date-parts":[[2020,8,2]]},"DOI":"10.1080\/17476348.2020.1764354","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T02:35:43Z","timestamp":1591324543000},"page":"777-789","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":23,"title":["Human rhinovirus infection and COPD: role in exacerbations and potential for therapeutic targets"],"prefix":"10.1080","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-9508","authenticated-orcid":false,"given":"John","family":"Cafferkey","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3381-8936","authenticated-orcid":false,"given":"James Andrew","family":"Coultas","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-9978","authenticated-orcid":false,"given":"Patrick","family":"Mallia","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, London, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0218PP"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909883"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1.133"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0469-6"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-40"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S36997"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.07.010"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.867842"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00014814"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2019-000458"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.04.013"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1054OC"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1610"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.08.020"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00079409"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.041822"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13032"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104-0597OC"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0842-8"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1159\/000327203"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134004"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803185"},{"issue":"10","key":"cit0023","first-page":"CD010257","volume":"29","author":"Vollenweider DJ","year":"2018","journal-title":"Cochrane Database Syst Rev (Online)"},{"issue":"2","key":"cit0024","first-page":"225","volume":"121","author":"Smith CB","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5613.287"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)01061-0"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023514"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200112-118BC"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ1214"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1159\/000448555"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07953-9"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6989.1225"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.9.2105011"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S30568"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S191946"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00253.2019"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.07.011"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0530"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209023"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.07.010"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2225"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-859OC"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00407-2019"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-008-7327-5"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d19.x"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01517.x"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12656"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-704OC"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05120-11"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi141"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.01109s4609"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411030112"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601942113"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43167-w"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-5806fje"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500172R"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2506OC"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1007\/s12560-019-09397-x"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00547-2020"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1111\/all.14238"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa242"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30103-6"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.05.009"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-116"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0833OC"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2637"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.35.11.2864-2868.1997"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.3.9117003"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804181105"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15337.1"},{"key":"cit0073","first-page":"e2","volume":"3","author":"Lau SK","year":"2010","journal-title":"Emerg Health Threats J"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00077-12"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.010"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5449"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00303-13"},{"issue":"15","key":"cit0078","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1016\/S0021-9258(17)30361-7","volume":"253","author":"Ambros V","year":"1978","journal-title":"J Biol Chem"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.3390\/v8030082"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.277-288.2005"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421178112"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.01.052"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1120-0"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.03.008"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001178"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1086\/315504"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1086\/513922"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00162-06"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093620"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-100114-055249"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2MIR0817-342R"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900165"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.039"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54567-3"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00150.2009"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140654"},{"issue":"8","key":"cit0099","first-page":"2771","volume":"118","author":"Kang MJ","year":"2008","journal-title":"J Clin Invest"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-561OC"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199612"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S105948"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217803"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0306OC"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0188OC"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200911-1673OC"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01826.x"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-15"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201650"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.011"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0202-x"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2011.08.004"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0806OC"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201302-0341OC"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00223113"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04574-1"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1086\/379833"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.03.003"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-136OC"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00036709"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02908"},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.081752"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201806-1095OC"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201947963"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2019.1563487"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.10.017"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13741"},{"key":"cit0128","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-203178"},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S142378"},{"issue":"4","key":"cit0130","first-page":"420","volume":"147","year":"1992","journal-title":"CMAJ"},{"key":"cit0131","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70040-7"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70169-9"},{"key":"cit0133","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.01.012"},{"key":"cit0134","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2014.03.004"},{"key":"cit0135","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-98"},{"key":"cit0136","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2018.04.002"},{"key":"cit0137","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60403-2"},{"key":"cit0138","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201709-1807OC"},{"key":"cit0139","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713901"},{"key":"cit0140","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.46.100192.003223"},{"key":"cit0141","doi-asserted-by":"publisher","DOI":"10.1086\/375069"},{"key":"cit0142","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03328-14"},{"key":"cit0143","unstructured":"Available from: https:\/\/www.genengnews.com\/topics\/drug-discovery\/aviragen-antiviral-drug-vapendavir-fails-phase-iib-study-in-asthma-patients\/81253873\/?q=America%20Stem%20Cell"},{"key":"cit0144","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.4.727"},{"key":"cit0145","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.2.290"},{"key":"cit0146","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11000"},{"key":"cit0147","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01746-13"},{"key":"cit0148","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.12.3907-3916.2003"},{"key":"cit0149","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(88)90055-1"},{"key":"cit0150","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.19.1797"},{"key":"cit0151","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003520"},{"key":"cit0152","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2235OC"},{"key":"cit0153","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201901-0214OC"},{"key":"cit0154","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.64.9.4099-4107.1990"},{"key":"cit0155","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0039-2"},{"key":"cit0156","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004039"},{"key":"cit0157","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003669"},{"key":"cit0158","first-page":"CD001288","volume":"9","author":"Walters JA","year":"2014","journal-title":"Cochrane Database Syst Rev (Online)"},{"key":"cit0159","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1553OC"},{"key":"cit0160","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00062614"},{"key":"cit0161","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30176-6"},{"key":"cit0162","first-page":"2","volume":"6","author":"Marcos PJ","year":"2018","journal-title":"Med Sci"},{"key":"cit0163","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1541"},{"key":"cit0164","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1067OC"},{"key":"cit0165","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2.473"}],"container-title":["Expert Review of Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17476348.2020.1764354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T13:37:41Z","timestamp":1620481061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17476348.2020.1764354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":165,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,2]]}},"alternative-id":["10.1080\/17476348.2020.1764354"],"URL":"https:\/\/doi.org\/10.1080\/17476348.2020.1764354","relation":{},"ISSN":["1747-6348","1747-6356"],"issn-type":[{"value":"1747-6348","type":"print"},{"value":"1747-6356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierx20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierx20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}