{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:32:05Z","timestamp":1792661525861,"version":"4.5.0"},"reference-count":54,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Respiratory Medicine"],"published-print":{"date-parts":[[2026,10,3]]},"DOI":"10.1080\/17476348.2026.2699459","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:50:34Z","timestamp":1783327834000},"page":"1183-1191","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Upper and lower airway crosstalk in acute exacerbations of COPD: a clinical and biological overview"],"prefix":"10.1080","volume":"20","author":[{"given":"Simone","family":"Ielo","sequence":"first","affiliation":[{"name":"San Donato Hospital, USL Tuscany South East","place":["Arezzo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Carriera","sequence":"additional","affiliation":[{"name":"Catholic University of Sacred Heart","place":["Roma, Italy"]},{"name":"Santa Maria della Misericordia Hospital","place":["Perugia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier-Valerio","family":"Mari","sequence":"additional","affiliation":[{"name":"San Carlo di Nancy Hospital","place":["Roma, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Barone","sequence":"additional","affiliation":[{"name":"Catholic University of Sacred Heart","place":["Roma, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cefaloni","sequence":"additional","affiliation":[{"name":"Catholic University of Sacred Heart","place":["Roma, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Loperfido","sequence":"additional","affiliation":[{"name":"San Camillo Forlanini Hospital","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Coppola","sequence":"additional","affiliation":[{"name":"ASL Roma 1","place":["Roma, Italy"]},{"name":"Unicamillus International Medical University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Baglioni","sequence":"additional","affiliation":[{"name":"Santa Maria della Misericordia Hospital","place":["Perugia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"De Corso","sequence":"additional","affiliation":[{"name":"Santa Maria della Misericordia Hospital","place":["Perugia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Scala","sequence":"additional","affiliation":[{"name":"San Donato Hospital, USL Tuscany South East","place":["Arezzo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2020.05.002"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1819PP"},{"issue":"25","key":"e_1_3_4_6_1","first-page":"00432","article-title":"GOLD COPD report: 2026 update","volume":"2213","author":"Venkatesan P.","year":"2025","unstructured":"Venkatesan P. GOLD COPD report: 2026 update. Lancet Respir Med. 2025;S2213-2600(25):00432\u20131.","journal-title":"Lancet Respir Med"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.040527"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S438893"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2024-003110"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S433183"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000010978.62527.4e"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-704OC"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.006650"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61382-8"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092506"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00241-6"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024350"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201710-815OC"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.011"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0833OC"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00223113"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0200TR"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.741989"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04574-1"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972307079512"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02210-2022"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9091944"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.11.001"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0455CI"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines14040891"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201408-1458OC"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2026.107012"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-026-01271-8"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00299-6"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2401304"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303951"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2413181"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708208"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132836"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2017.1335697"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104-0597OC"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S493219"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.12932\/AP-240724-1896"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.01.010"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.401"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.036"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S124248"},{"key":"e_1_3_4_48_1","first-page":"200","article-title":"Mouth breathing and its relationship to some oral and medical conditions: physiopathological mechanisms involved","volume":"15","author":"Triana BEG","year":"2016","unstructured":"Triana BEG, Ali AH, Le\u00f3n IBG. Mouth breathing and its relationship to some oral and medical conditions: physiopathological mechanisms involved. Rev Habanera Cienc M\u00e9dicas. 2016;15:200\u2013212.","journal-title":"Rev Habanera Cienc M\u00e9dicas"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm16010021"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01406-2015"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1085551"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-026-01281-6"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03791-23"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219962"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S481406"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-026-02357-1"}],"container-title":["Expert Review of Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17476348.2026.2699459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/17476348.2026.2699459","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17476348.2026.2699459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:18:29Z","timestamp":1790871509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17476348.2026.2699459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,3]]}},"alternative-id":["10.1080\/17476348.2026.2699459"],"URL":"https:\/\/doi.org\/10.1080\/17476348.2026.2699459","relation":{},"ISSN":["1747-6348","1747-6356"],"issn-type":[{"value":"1747-6348","type":"print"},{"value":"1747-6356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierx20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierx20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}