{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:07:29Z","timestamp":1779800849757,"version":"3.53.1"},"reference-count":72,"publisher":"Informa UK Limited","issue":"5","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170418"],"award-info":[{"award-number":["82170418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271618"],"award-info":[{"award-number":["82271618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471616"],"award-info":[{"award-number":["82471616"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFA015"],"award-info":[{"award-number":["2022CFA015"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFB195"],"award-info":[{"award-number":["2025AFB195"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central Guiding Local Science and Technology Development Project","award":["2022BGE237"],"award-info":[{"award-number":["2022BGE237"]}]},{"name":"Key Research and Development Program of Hubei Province","award":["2023BCB139"],"award-info":[{"award-number":["2023BCB139"]}]},{"name":"Regional Science and Technology Innovation Plan Project of Hubei Province","award":["2025EIA015"],"award-info":[{"award-number":["2025EIA015"]}]},{"name":"Regional Science and Technology Innovation Plan Project of Hubei Province","award":["2024EIA050"],"award-info":[{"award-number":["2024EIA050"]}]},{"name":"Science and Technology Innovation Platform Project of Hubei Province","award":["2025CCB016"],"award-info":[{"award-number":["2025CCB016"]}]},{"name":"Science and Technology Innovation Platform Project of Hubei Province","award":["2025CSA107"],"award-info":[{"award-number":["2025CSA107"]}]},{"name":"Health Science and Technology Project of Hubei Province","award":["WJ2025Q010"],"award-info":[{"award-number":["WJ2025Q010"]}]},{"name":"Medical and Health Research Project of Yichang","award":["A25-2\u2013001"],"award-info":[{"award-number":["A25-2\u2013001"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2026,5,4]]},"DOI":"10.1080\/17501911.2026.2665450","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:43:31Z","timestamp":1777880611000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["The signaling upstream of DOT1L-mediated H3K79 methylation"],"prefix":"10.1080","volume":"18","author":[{"given":"Chu","family":"Chen","sequence":"first","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canran","family":"Lv","sequence":"additional","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhu","sequence":"additional","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Chen","sequence":"additional","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Li","sequence":"additional","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"China Three Gorges University & Yichang Central People\u2019s Hospital","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Ischemic Cardiovascular Disease","place":["Yichang, China"]},{"name":"Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(80)84956-3"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1761"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00889a003"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(02)00287-3"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X16671287"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8010011"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2057811"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.06.010"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3294"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.112023"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00901-6"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00114-4"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01856-4"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00759-6"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.126813"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000190"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.256354.114"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-6-20"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.009"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.2c00887"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10953"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.328138"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.115"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030839"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334359"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.002"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200433200"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02076-07"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.029"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.058"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.05.013"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110369"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0146-7"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10589"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.05.009"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1712"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.176487.114"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.04.013"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.213"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.06.016"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904672116"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.1MA0421-010R"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.08.019"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.311639.118"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.10.001"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91406"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00175"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.049"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2019.1699991"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107107108"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167117"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-1299"},{"issue":"1","key":"e_1_3_5_55_1","first-page":"276","article-title":"DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma","volume":"13","author":"Hou Y","year":"2023","unstructured":"Hou Y, Huang S, Liu J, et al. DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma. Am J Cancer Res. 2023;13(1):276\u2013292.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-22-0418"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1663"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2022.2052640"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.384057"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.027"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3385"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.109389.110"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019101564"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15889"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.01.018"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1900150"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.5.1157"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109739"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07861"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.39013"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-024-00838-9"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.04.033"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03590-5"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.07.034"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17501911.2026.2665450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:45:26Z","timestamp":1779799526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17501911.2026.2665450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,4]]}},"alternative-id":["10.1080\/17501911.2026.2665450"],"URL":"https:\/\/doi.org\/10.1080\/17501911.2026.2665450","relation":{},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"value":"1750-1911","type":"print"},{"value":"1750-192X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}