{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:58:20Z","timestamp":1787007500260,"version":"build-2736575974"},"reference-count":52,"publisher":"Informa UK Limited","issue":"6","funder":[{"name":"not funded"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2018,6,3]]},"DOI":"10.1080\/17512433.2018.1473760","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T18:04:36Z","timestamp":1525457076000},"page":"641-650","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and safety of iron chelators in thalassemia and sickle cell disease: a multiple treatment comparison network meta-analysis and trial sequential analysis"],"prefix":"10.1080","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-6503","authenticated-orcid":false,"given":"Kannan","family":"Sridharan","sequence":"first","affiliation":[{"name":",","place":["Bahrain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowri","family":"Sivaramakrishnan","sequence":"additional","affiliation":[{"name":",","place":["Fiji islands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,5,18]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92175-5"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-048868"},{"key":"e_1_3_4_5_1","first-page":"328","article-title":"Iron overload in beta thalassaemia major and intermedia patients","volume":"8","author":"Mishra AK","year":"2013","unstructured":"Mishra AK, Tiwari A. Iron overload in beta thalassaemia major and intermedia patients. Maedica (Buchar). 2013;8:328\u2013332.","journal-title":"Maedica (Buchar)"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70064-9"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1004810"},{"key":"e_1_3_4_8_1","volume-title":"Guidelines for the management of transfusion dependent thalassaemia (TDT) [Internet]","author":"Porter J","year":"2014","unstructured":"Porter J, Viprakasit V.Iron overload and chelation. In: Cappellini MD, Cohen A, Porter J, et al. editors. Guidelines for the management of transfusion dependent thalassaemia (TDT) [Internet]. 3rd. Nicosia (CY): Thalassaemia International Federation, 2014. Chapter 3.[cited 2017 Sep 08]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK269373\/","edition":"3"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310903"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_3_4_11_1","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins JPT","unstructured":"Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions.5.1.0 edition. [cited 2017 May 1]. Available from: www.cochrane-handbook.org","edition":"5"},{"key":"e_1_3_4_12_1","article-title":"How to read a funnel plot in a meta-analysis","volume":"16","author":"Sedgwick P","year":"2015","unstructured":"Sedgwick P, Marston L. How to read a funnel plot in a meta-analysis. Bmj. 2015;16:351: h4718.","journal-title":"Bmj"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_3_4_14_1","unstructured":"Barendregt JJ Doi SA. MetaXL user guide. [cited 2017 Jul 21]. Available from: http:\/\/www.epigear.com\/index_files\/MetaXL%20User%20Guide.pdf"},{"key":"e_1_3_4_15_1","unstructured":"Thorlund K Engstrom J Wetterslev J et al. Trial sequential analysis. Copenhagen trial unit. [cited 2017 Jun 22]. Available from: http:\/\/www.ctu.dk\/tools-and-links\/trial-sequential-analysis.aspx"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530245"},{"key":"e_1_3_4_17_1","article-title":"Therapeutic effects of deferoxamine and silymarin versus deferoxamine alone in \u03b2-thalassemia major based on findings of liver MRI","author":"Adibi A","year":"2012","unstructured":"Adibi A, Shayganfar A, Moayedi BS, et al. Therapeutic effects of deferoxamine and silymarin versus deferoxamine alone in \u03b2-thalassemia major based on findings of liver MRI. J Res Med Sci. 2012;S1(17):73\u20137.","journal-title":"J Res Med Sci"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11414"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2014.04.004"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24024"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3430"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12507"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0471-2"},{"key":"e_1_3_4_24_1","first-page":"1241","article-title":"A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia","volume":"91","author":"Galanello R","year":"2006","unstructured":"Galanello R, Kattamis A, Piga A, et al. A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia. Haematologica. 2006;91:1241\u20131243.","journal-title":"Haematologica"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003253350"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00681.x"},{"key":"e_1_3_4_27_1","first-page":"21","article-title":"Comparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children","volume":"41","author":"Gomber S","year":"2004","unstructured":"Gomber S, Saxena R, Madan N. Comparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children. Indian Pediatr. 2004;41:21\u201327.","journal-title":"Indian Pediatr"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630260600642617"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2013.065"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526515666150731113305"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.19082\/2425"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0510"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07609.x"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1179\/102453312X13376952196610"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12061"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04240.x"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13309-0"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1081\/HEM-120021538"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2948"},{"key":"e_1_3_4_40_1","first-page":"873","article-title":"Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload","volume":"91","author":"Piga A","year":"2006","unstructured":"Piga A, Galanello R, Forni GL, et al. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica. 2006;91:873\u2013880.","journal-title":"Haematologica"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412692"},{"key":"e_1_3_4_42_1","first-page":"655","article-title":"Comparison between deferoxamine and combined therapy with deferoxamine and deferiprone in iron overloaded thalassemia patients","volume":"12","author":"Tamaddoni A","year":"2010","unstructured":"Tamaddoni A, Ramezani MS. Comparison between deferoxamine and combined therapy with deferoxamine and deferiprone in iron overloaded thalassemia patients. Iranian Red Crescent Med J. 2010;12:655\u2013659.","journal-title":"Iranian Red Crescent Med J"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.648790"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06455.x"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23569"},{"key":"e_1_3_4_46_1","first-page":"297","article-title":"Comparison of deferiprone and deferrioxamine for the treatment of transfusional iron overload in children with beta thalassemia major","volume":"6","author":"Waheed N","year":"2014","unstructured":"Waheed N, Ali S, Butt MA. Comparison of deferiprone and deferrioxamine for the treatment of transfusional iron overload in children with beta thalassemia major. J Ayub Med Coll Abbottabad. 2014;6:297\u2013300.","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"e_1_3_4_47_1","first-page":"488","article-title":"Efficacy of combined desferrioxamine and deferiprone versus single desferrioxamine therapy in patients with major thalassemia","volume":"12","author":"Zareifar S","year":"2009","unstructured":"Zareifar S, Jabbari A, Cohan N, et al. Efficacy of combined desferrioxamine and deferiprone versus single desferrioxamine therapy in patients with major thalassemia. Arch Iran Med. 2009;12:488\u2013491.","journal-title":"Arch Iran Med"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245330701521614"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S72463"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007476.pub2"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004839.pub3"},{"key":"e_1_3_4_52_1","unstructured":"Algren A Review of oral iron chelators (deferiprone and deferasirox) for the treatment of iron overload in pediatric patients. [cited 8 September 2017]. Available from: http:\/\/www.who.int\/selection_medicines\/committees\/expert\/18\/applications\/OralIronChelators.pdf"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-010-0030-4"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.05.005"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2018.1473760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:22:54Z","timestamp":1770909774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2018.1473760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,18]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6,3]]}},"alternative-id":["10.1080\/17512433.2018.1473760"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2018.1473760","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"value":"1751-2433","type":"print"},{"value":"1751-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,18]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}