{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:12:51Z","timestamp":1785255171708,"version":"3.55.0"},"reference-count":115,"publisher":"Informa UK Limited","issue":"12","funder":[{"name":"National Science and Technology Major Projects for \u2018Major New Drugs Innovation and Development\u2019","award":["2017ZX09304029-002"],"award-info":[{"award-number":["2017ZX09304029-002"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2020,12,1]]},"DOI":"10.1080\/17512433.2020.1850257","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T19:51:56Z","timestamp":1605210716000},"page":"1295-1308","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Oral drugs used to treat persistent pulmonary hypertension of the newborn"],"prefix":"10.1080","volume":"13","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-E","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"van den Anker","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Children\u2019s National Hospital, Washington, DC, USA"},{"name":"Departments of Pediatrics, Pharmacology & Physiology, Genomics & Precision Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"},{"name":"Department of Paediatric Pharmacology and Pharmacometrics, University of Basel Children\u2019s Hospital, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Lin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Clinical Trial Center, Shandong Provincial Qianfoshan Hospital, the First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1830-338X","authenticated-orcid":false,"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Clinical Pharmacy, Clinical Trial Center, Shandong Provincial Qianfoshan Hospital, the First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200608030-00004"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1165"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1536740"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1239496"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.12.004"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040291"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13051"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.105958"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1368-4"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08632-4"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01386.x"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13558.x"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050982"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70370-1"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.143"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008324180"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0409-0"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868030-00009"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1159\/000298137"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00137511"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00009-7"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8543"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1038\/348732a0"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119274"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994352"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81552-5"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0531-y"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S6208"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-68964-5_1"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119555"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200411-1587OC"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.08.012"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06250-X"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1422-9"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.02.003"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.157"},{"issue":"90","key":"cit0038","volume":"177","author":"Steinhorn RH","year":"2016","journal-title":"J Pediatr"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050010"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805143382001"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"cit0042","unstructured":"FDA US. FDA drug safety communication: FDA clarifies warning about pediatric use of revatio (sildenafil) for pulmonary arterial hypertension. FDA. 2014. [cited 2014 Mar 31].http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm390876.htm"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802220482"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21060"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1177\/0009922807303546"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1801-3"},{"issue":"3","key":"cit0047","first-page":"149","volume":"30","author":"Cavallaro G","year":"2008","journal-title":"Pediatr Med Chir"},{"key":"cit0048","first-page":"274639","volume":"2015","author":"Demir N","year":"2015","journal-title":"Case Rep Pulmonol"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.062885"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-1724-x"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2006.00835.x"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600736713"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2007.448"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.4314\/eamj.v83i6.9442"},{"key":"cit0055","first-page":"4","volume":"2","author":"Engelbrecht AL","year":"2008","journal-title":"SAJCH"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.5385\/jksn.2011.18.1.124"},{"issue":"4","key":"cit0057","first-page":"677","volume":"29","author":"Hussain AS","year":"2017","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2017.1.16223"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22985"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200508000-00414"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-15814137"},{"issue":"3","key":"cit0062","first-page":"S64","volume":"94","author":"Khorana M","year":"2011","journal-title":"J Med Assoc Thai"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.116406"},{"issue":"2","key":"cit0064","first-page":"203","volume":"4","author":"Prithviraj D","year":"2016","journal-title":"Int J Sci Study"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.012"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0523"},{"issue":"4","key":"cit0067","first-page":"159","volume":"73","author":"Torres RH","year":"2006","journal-title":"Revista Mexicana de Pediatria"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmq091"},{"issue":"1","key":"cit0069","first-page":"19","volume":"1","author":"Shaltout F","year":"2012","journal-title":"Int J Clin Pediatr"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-16161"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.839274"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0180-4"},{"key":"cit0073","first-page":"1","volume":"27","author":"Alipour MR","year":"2017","journal-title":"Iran J Pediatr"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138706"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443150-00003"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1177\/00912700222011300"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.06.027"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00005-5"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90127-7"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1177\/0091270002239701"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00625.x"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.060137"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.00027.x"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00739.x"},{"issue":"4","key":"cit0085","first-page":"392","volume":"28","author":"Warrington JS","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1080\/004982599238687"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.177"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02553.x"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10040187"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000055"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12997"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.02.019"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02726.x"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803306475"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005698"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-16915133"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901212"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.021956"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000077"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.36.3.160"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318179954c"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.179"},{"issue":"3","key":"cit0103","first-page":"111","volume":"21","author":"Roberts KE","year":"2009","journal-title":"Drug Des Devel Ther"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-159483"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.257.6.C1101"},{"issue":"1","key":"cit0106","first-page":"7","volume":"66","author":"Shiva A","year":"2016","journal-title":"Drug Res (Stuttg)"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.03.115"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02822.x"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0408-z"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008315315"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01722.x"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1197\/j.aem.2003.09.021"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.103"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0525"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.04.005"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2020.1850257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T10:42:07Z","timestamp":1620470527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2020.1850257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":115,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["10.1080\/17512433.2020.1850257"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2020.1850257","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"value":"1751-2433","type":"print"},{"value":"1751-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}