{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T23:40:50Z","timestamp":1747179650074,"version":"3.40.5"},"reference-count":104,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2021,3,4]]},"DOI":"10.1080\/17512433.2021.1888714","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T15:00:08Z","timestamp":1613660408000},"page":"315-322","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Concomitant use of dexamethasone and tetracyclines: a potential therapeutic option for the management of severe COVID-19 infection?"],"prefix":"10.1080","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-3443","authenticated-orcid":false,"given":"Harmanjit","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prerna","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasbir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Government Medical College and Hospital, Chandigarh, India"},{"name":"Department of Pharmacology, Rajindra Hospital, Patiala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Saurabh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Dayanand Medical College and Hospital, Ludhiana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CS","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7768-7304","authenticated-orcid":false,"given":"Ashish Kumar","family":"Kakkar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"cit0001","unstructured":"WHO Coronavirus Disease (COVID-19) Situation reports 2021. [cited 2021 Jan 19]. Available from: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/situation-reports"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000670"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00334-2020"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0339OC"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061088"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30076-X"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12101"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003256"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31305-2"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.09.259"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa818"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00143"},{"issue":"6","key":"cit0015","first-page":"441","volume":"76","author":"Thompson BT","year":"2010","journal-title":"Minerva anestesiologica"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02049-2020"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01708"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.06.017"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.03.003"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0629-x"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.3390\/v11010059"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.06.061"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.050"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2512"},{"key":"cit0025","unstructured":"WHO welcomes preliminary results about dexamethasone use in treating critically ill COVID-19 patients 2020. [cited 2020 Aug 27]. Available from: https:\/\/www.who.int\/news-room\/detail\/16-06-2020-who-welcomes-preliminary-results-about-dexamethasone-use-in-treating-critically-ill-covid-19-patients"},{"key":"cit0026","unstructured":"Coronavirus breakthrough: dexamethasone is first drug shown to save lives. [cited 2020 Aug 27]. Available from:https:\/\/www.nature.com\/articles\/d41586\u2013020\u201301824\u20135"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2395"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1782190"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvaa049"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01545"},{"key":"cit0031","unstructured":"DECADRON\u00ae (DEXAMETHASONE TABLETS, USP). [cited 2020 Aug 17]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2004\/11664slr062_decadron_lbl.pdf"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(98)01229-2"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1210\/me.2001-0278"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5234.286"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04984.x"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000057900.19201.55"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30317-2"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.062"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00170"},{"journal-title":"N Engl J Med","year":"2021","author":"RECOVERY Collaborative Group","key":"cit0040"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2007764"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31022-9"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0897-1"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.6.1441"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00482.x"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(00)00039-1"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.4.496"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30417-5"},{"key":"cit0050","unstructured":"The National Institutes of Health COVID-19 2020. Treatment Guidelines Panel Provides Recommendations for Dexamethasone in Patients with COVID-19. [cited 2020 Aug 27]. Available from: https:\/\/www.covid19treatmentguidelines.nih.gov\/dexamethasone\/"},{"key":"cit0051","unstructured":"WHO. Q&A: dexamethasone and COVID-19 2020. [cited 2020 Aug 27]. Available from: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/question-and-answers-hub\/q-a-detail\/q-a-dexamethasone-and-covid-19?gclid=CjwKCAjwmrn5BRB2EiwAZgL9onlQZ4vlAexO-xmmFH8W9arD8t7FFXJ6fQycJxvXJlrialCFn-VLlxoCi9UQAvD_BwE"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1163"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-018-0321-9"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2100"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.2.159"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa421"},{"key":"cit0057","first-page":"28","author":"Cano EJ","year":"2020","journal-title":"Chest."},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003262"},{"key":"cit0059","first-page":"12","author":"Annane D","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.65.2.232-260.2001"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14494"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1838276"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.190105"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00047.2010"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110054"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600268"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb01082.x"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.18297\/jri\/vol4\/iss1\/9"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.03.014"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000129334.05181.b6"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(03)01022-X"},{"issue":"2","key":"cit0072","first-page":"82","volume":"82","author":"Ghasemi S","year":"2018","journal-title":"Can J Vet Res"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13403"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12039"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.81"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.a2016.0022"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12488"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-015-9592-2"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0384-9"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-019-0214-z"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00864"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02238-20"},{"key":"cit0083","doi-asserted-by":"crossref","first-page":"118080","DOI":"10.1016\/j.lfs.2020.118080","volume":"257","author":"Bharadwaj S, Lee KE, Dwivedi VD, Kang SG. Computational insights into tetracyclines as inhibitors against SARS-CoV-","year":"2020","journal-title":"Life Sci"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-40141\/v1"},{"issue":"21","key":"cit0085","volume":"25","author":"Gendrot M","year":"2020","journal-title":"Mol Basel Switz"},{"key":"cit0086","volume":"05","author":"Ahmad I, Alam M, Saadi R, Mahmud S, Saadi E. Doxycycline and Hydroxychloroquine as Treatment for High-Risk COVID-","year":"2020","journal-title":"medRxiv"},{"issue":"8","key":"cit0087","first-page":"e9658","volume":"12","author":"Alam MM","year":"2020","journal-title":"Cureus"},{"key":"cit0088","first-page":"27","author":"Cag Y","year":"2020","journal-title":"Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620951053"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-38896\/v1"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106168"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.22.20154542"},{"key":"cit0093","first-page":"e14694","volume":"22","author":"Gironi LC","year":"2020","journal-title":"Dermatol Ther"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"cit0096","unstructured":"FDA. Minocycline label 2020. [cited 2020 Aug 27]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2010\/050649023lbl.pdf"},{"key":"cit0097","unstructured":"DORYX\u00ae (doxycycline hyclate). [cited 2020 Aug 27]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2008\/050795s005lbl.pdf"},{"key":"cit0098","first-page":"1","volume":"24","author":"Manchanda K","year":"2020","journal-title":"Int J Risk Safety Med"},{"key":"cit0099","unstructured":"Drug interactions checker - Medscape drug reference database [Internet]. [cited 2020 Sep 3]. Available from: https:\/\/reference.medscape.com\/drug-interactionchecker"},{"key":"cit0100","unstructured":"Corticosteroids for COVID-19 (2021). Available at: https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Corticosteroids-2020.1 (cited 2021 Jan 27)."},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26294"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13429"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173717"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.4155\/fdd-2020-0010"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2021.1888714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T11:49:18Z","timestamp":1617104958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2021.1888714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,4]]},"references-count":104,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,4]]}},"alternative-id":["10.1080\/17512433.2021.1888714"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2021.1888714","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"type":"print","value":"1751-2433"},{"type":"electronic","value":"1751-2441"}],"subject":[],"published":{"date-parts":[[2021,3,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}