{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:37:36Z","timestamp":1793759856322,"version":"4.6.1"},"reference-count":175,"publisher":"Informa UK Limited","issue":"5","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Chugai Pharmaceutical Co., Ltd"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2022,5,4]]},"DOI":"10.1080\/17512433.2022.2097905","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T09:14:41Z","timestamp":1657098881000},"page":"575-592","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":55,"title":["Current status and prospects of IL-6\u2013targeting therapy"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-4409","authenticated-orcid":false,"given":"Masashi","family":"Narazaki","sequence":"first","affiliation":[{"name":"Department of Advanced Clinical and Translational Immunology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan"},{"name":"Department of Respiratory Medicine, Clinical Immunology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan"},{"name":"Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.397"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1038\/324073a0"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115806"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7547"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1038\/368339a0"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3153"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113528"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.026"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxab011"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016295"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7061"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.45"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.018"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2577-9"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0378-1"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.4.1360.1360"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)90096-5"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0081-x"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa324"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000841"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0961-z"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.AC119.007558"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa041"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2010229117"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07186.x"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10998"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.027"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202768"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4989"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3632"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.4.1120.1120"},{"issue":"11","key":"cit0033","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.4049\/jimmunol.161.11.6347","volume":"161","author":"Muller-Newen G","year":"1998","journal-title":"J Immunol"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1126\/science.3136546"},{"issue":"9","key":"cit0035","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.4049\/jimmunol.143.9.2900","volume":"143","author":"Hirata Y","year":"1989","journal-title":"J Immunol"},{"issue":"4","key":"cit0036","first-page":"851","volume":"53","author":"Sato K","year":"1993","journal-title":"Cancer Res"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.5.1198.1198"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1007\/BF00832010"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4602"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1295850"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126532"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60250-0"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204573"},{"issue":"7","key":"cit0044","first-page":"1426","volume":"30","author":"Nishimoto N","year":"2003","journal-title":"J Rheumatol"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009350623"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-155846"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1002\/art.39093"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210310"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.782"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4926168"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.609522"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.1887925"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2060204"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70319-5"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.121"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-219876"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30401-4"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211328"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-018-0320-3"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115327"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2020.1022"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1002\/art.20303"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0343-1"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.6.H2954"},{"issue":"4","key":"cit0065","first-page":"541","volume":"56","author":"Moots RJ","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1186\/ar4323"},{"issue":"5","key":"cit0068","first-page":"664","volume":"33","author":"Gossec L","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2720"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken363"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1002\/art.22175"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214894"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1002\/art.38202"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32341-2"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001662"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1002\/art.38324"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1038\/nature08114"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307419110"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1002\/art.34477"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12017"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0526-4"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040391"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1052-8"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1002\/art.30242"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05044-4"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04944-x"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.854079"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190344"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151092"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.009"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1093\/rap\/rky029"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02629"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex238"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu363"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60454-7"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.844404"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1002\/art.38984"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613849"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211878"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.04.002"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2017.1416924"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213920"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2016-0020"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002053"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138554"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071583"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2021.1949286"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26509"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1055\/a-1336-2371"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06158"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017385108"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102421"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1691"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901747"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0905750"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307399"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.07.038"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0479"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70253-2"},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0442-6"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001052"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"issue":"8","key":"cit0125","first-page":"100140","volume":"1","author":"Gao X","year":"2020","journal-title":"ell Rep Med"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00232-4"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30318-0"},{"key":"cit0128","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200726"},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.113696"},{"key":"cit0130","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-021-00304-0"},{"key":"cit0131","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072157"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23875"},{"key":"cit0133","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.003103"},{"key":"cit0134","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw171"},{"key":"cit0135","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3842-y"},{"key":"cit0136","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.053318"},{"key":"cit0137","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221126"},{"key":"cit0138","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16459"},{"key":"cit0139","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23539"},{"key":"cit0140","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.033"},{"key":"cit0141","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13268"},{"key":"cit0142","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.06.014"},{"key":"cit0143","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.854048"},{"key":"cit0144","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.05.017"},{"key":"cit0145","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220876"},{"key":"cit0146","doi-asserted-by":"publisher","DOI":"10.1177\/1078155217745144"},{"key":"cit0147","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24412-1"},{"key":"cit0148","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102696"},{"key":"cit0149","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203559"},{"key":"cit0150","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204963"},{"key":"cit0151","doi-asserted-by":"publisher","DOI":"10.1002\/art.39700"},{"key":"cit0152","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009050"},{"issue":"6","key":"cit0153","first-page":"905","volume":"77","author":"Rutherford AI","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"cit0154","doi-asserted-by":"publisher","DOI":"10.1002\/art.39399"},{"key":"cit0155","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.01.001"},{"key":"cit0156","doi-asserted-by":"publisher","DOI":"10.1038\/nature14228"},{"key":"cit0157","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209773"},{"key":"cit0158","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.01.002"},{"key":"cit0159","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2016.1147405"},{"key":"cit0160","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.05.004"},{"key":"cit0161","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez100"},{"key":"cit0162","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key091"},{"key":"cit0163","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112802"},{"key":"cit0164","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120386"},{"key":"cit0165","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-019-0364-z"},{"key":"cit0166","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1181315"},{"key":"cit0167","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.01.006"},{"key":"cit0168","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1214340"},{"key":"cit0169","doi-asserted-by":"publisher","DOI":"10.1080\/13497413.2018.1481582"},{"key":"cit0170","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0343-9"},{"key":"cit0171","doi-asserted-by":"publisher","DOI":"10.1002\/art.27221"},{"key":"cit0172","doi-asserted-by":"publisher","DOI":"10.1002\/art.30158"},{"key":"cit0173","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068064"},{"key":"cit0174","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30363-4"},{"issue":"1","key":"cit0175","first-page":"22","volume":"30","author":"Yamaguchi N","year":"2003","journal-title":"J Rheumatol"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2022.2097905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T23:40:45Z","timestamp":1676072445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2022.2097905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,4]]},"references-count":175,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,4]]}},"alternative-id":["10.1080\/17512433.2022.2097905"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2022.2097905","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"value":"1751-2433","type":"print"},{"value":"1751-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}