{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:28:59Z","timestamp":1762846139844,"version":"build-2065373602"},"reference-count":65,"publisher":"Informa UK Limited","issue":"2","funder":[{"name":"No funding"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1080\/17512433.2024.2304015","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:46:30Z","timestamp":1704858390000},"page":"119-130","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Clinical trial design for assessing hypertension medications: are critical circadian chronopharmacological principles being taking into account?"],"prefix":"10.1080","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-5901","authenticated-orcid":false,"given":"Ram\u00f3n C","family":"Hermida","sequence":"first","affiliation":[{"name":"Universidade de Vigo","place":["Vigo, Spain"]},{"name":"SERGAS-UVIGO","place":["Vigo, Spain"]},{"name":"The University of Texas at Austin","place":["Austin, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9184-0739","authenticated-orcid":false,"given":"Michael H","family":"Smolensky","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin","place":["Austin, USA"]},{"name":"The University of Texas Health Science Center at Houston","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2255-1500","authenticated-orcid":false,"given":"Artemio","family":"Moj\u00f3n","sequence":"additional","affiliation":[{"name":"Universidade de Vigo","place":["Vigo, Spain"]},{"name":"SERGAS-UVIGO","place":["Vigo, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-0124","authenticated-orcid":false,"given":"Jos\u00e9 R","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidade de Vigo","place":["Vigo, Spain"]},{"name":"SERGAS-UVIGO","place":["Vigo, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.006"},{"key":"e_1_3_4_4_1","unstructured":"National Institute for Health and Clinical Excellence. Hypertension in adults: diagnosis and management. NICE Guideline 136: Methods Evidence And Recommendations. National Clinical Guidelines Centre London (UK). 2019 [cited 2023 Jul 28]. Available from: https:\/\/www.nice.org.uk\/guidance\/ng136"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s1440-019-0284-9"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200211000-00017"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022273"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000170138.56903.7a"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.087262"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61538-4"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.4"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.100727"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.21.2340"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833b49fe"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.043"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.230"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000355"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06981"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy475"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/So140-6736(23)00733-X"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2020.08.004"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2013.750490"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11499"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa078"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.02.003"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.715872"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c21008"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199835020-00001"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.4.2.175"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520801909247"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114045"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1825681"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115185"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2020.1850468"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.701457"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4806.20.06834-2"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.47"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.01.013"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101454"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2021.1931280"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420301"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.099502"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2010.510230"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz754"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.020"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801317"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.199562"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2021.2005084"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00512"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010313"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-2318-4"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.37349\/emed.2022.00107"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01786-X"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2023.2253288"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-021-00621-5"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.125"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.198101"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001987"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14344"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14179"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003240"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-9496-9_6"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.07.005"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.04.001"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2024.2304015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:27:07Z","timestamp":1762846027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2024.2304015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1080\/17512433.2024.2304015"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2024.2304015","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"type":"print","value":"1751-2433"},{"type":"electronic","value":"1751-2441"}],"subject":[],"published":{"date-parts":[[2024,1,12]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}