{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:14:08Z","timestamp":1777594448813,"version":"3.51.4"},"reference-count":86,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2025,12,2]]},"DOI":"10.1080\/17512433.2025.2594489","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:01:56Z","timestamp":1763722916000},"page":"1053-1062","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Botulinum toxin in focus: evolution, pharmacology, and its expanding clinical impact"],"prefix":"10.1080","volume":"18","author":[{"given":"Hira Bakhtiar","family":"Khan","sequence":"first","affiliation":[{"name":"James Cook University Hospital","place":["Middlesbrough, UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragnitha","family":"Chitteti","sequence":"additional","affiliation":[{"name":"Northern Care Alliance NHS Foundation Trust Greater Manchester","place":["Salford, UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehwash","family":"Nadeem","sequence":"additional","affiliation":[{"name":"James Cook University Hospital","place":["Middlesbrough, UK"]},{"name":"Newcastle University","place":["Newcastle, UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-007-0728-2"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14062021"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20024"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3295"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.02022.x"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410364676"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.012658"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11343-0"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11395-2"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16020101"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001903"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01882-9"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.06.001"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-016-1538-1"},{"key":"e_1_3_5_17_1","unstructured":"Supernus Pharmaceuticals Inc. Myobloc\u00ae (rimabotulinumtoxinB) injection for intramuscular or intraglandular use\u2014prescribing information. [cited 2025 Apr]. Available from: https:\/\/www.myobloc.com\/files\/Myobloc-Prescribing-Information.pdf"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004358"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002402"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14010036"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11010034"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-010-0069-x"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2020.02.020"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209821200"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328330dcca"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)13448-6"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.11.004"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.03.010"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.03.146"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.02.004"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1586845"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004927.pub4"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-021-02715-4"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004528"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13478"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.916305"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40123"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003633.pub4"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000311389.26145.95"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027953"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15090541"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0744-z"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2019.01.016"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007368"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-070705"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.08.097"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881121991827"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2015.08.001"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(02)00103-7"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins17030130"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13110751"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13010001"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2019.82795"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.68.1.50"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004228"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/20514158211016651"},{"issue":"11","key":"e_1_3_5_57_1","first-page":"1183","article-title":"Botulinum toxin type A in pregnancy","volume":"59","author":"Tan M","year":"2013","unstructured":"Tan M, Kim E, Koren G, et al. Botulinum toxin type A in pregnancy. Can Fam Physician. 2013;59(11):1183\u20131184.","journal-title":"Can Fam Physician"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2020.1707803"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207375"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins17040192"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.05.22.595434"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-017-1809-5"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24758"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.5005\/ijopmr-23-3-101"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2021.11.010"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.3678"},{"issue":"4","key":"e_1_3_5_67_1","first-page":"194","article-title":"The use of botulinum neurotoxin type A in a patient with refractory urge incontinence to facilitate the intravesical treatment of bladder carcinoma","volume":"16","author":"Fam M","year":"2014","unstructured":"Fam M, Gilhooly P. The use of botulinum neurotoxin type A in a patient with refractory urge incontinence to facilitate the intravesical treatment of bladder carcinoma. Rev Urol. 2014;16(4):194\u2013197.","journal-title":"Rev Urol"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15020095"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-015-0335-0"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114733"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.03.005"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-024-03883-x"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmrj.12713"},{"key":"e_1_3_5_74_1","unstructured":"Allergan. Botox\u00ae (onabotulinumtoxinA) for injection for intramuscular intradetrusor or intradermal use\u2014prescribing information. [cited 2025 Apr 15]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/103000s5320lbl.pdf"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001408.pub2"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12100661"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15885"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.2165\/11599840-000000000-00000"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2022.153341"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2021.00766"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006688"},{"issue":"4","key":"e_1_3_5_82_1","first-page":"1","article-title":"DaxibotulinumtoxinA-lanm (Daxxify\u2122): a comprehensive overview","volume":"28","author":"Salame N","year":"2023","unstructured":"Salame N, Eber AE, Dover J. DaxibotulinumtoxinA-lanm (Daxxify\u2122): a comprehensive overview. Skin Ther Lett. 2023;28(4):1\u20133.","journal-title":"Skin Ther Lett"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00139-20"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-022-02494-5"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00442-3"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032378"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins17040182"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200211001-00005"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2025.2594489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T14:01:42Z","timestamp":1767362502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2025.2594489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":86,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,2]]}},"alternative-id":["10.1080\/17512433.2025.2594489"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2025.2594489","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"value":"1751-2433","type":"print"},{"value":"1751-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}