{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:54:16Z","timestamp":1791219256337,"version":"4.1.0"},"reference-count":161,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2026,4,3]]},"DOI":"10.1080\/17512433.2026.2649611","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:37:22Z","timestamp":1773981442000},"page":"341-355","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Osteoarthritis and cardiometabolic diseases: shared mechanisms, modifiable risk factors, and integrated management strategies"],"prefix":"10.1080","volume":"19","author":[{"given":"Patricia YL.","family":"Chan","sequence":"first","affiliation":[{"name":"Kolling Institute of Medical Research","place":["St Leonards, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Yuan","sequence":"additional","affiliation":[{"name":"South China University of Technology","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3197-752X","authenticated-orcid":false,"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"The University of Sydney","place":["Sydney, Australia"]},{"name":"Royal North Shore Hospital","place":["St Leonards, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-08122-5"},{"key":"e_1_3_4_4_1","unstructured":"Sen RHJ. Osteoarthritis: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Copyright \u00a9 2025 StatPearls Publishing LLC.; StatPearls [Internet] 2025 Jan [updated 2023 Feb 20; cited 2025]; Available from: www.ncbi.nlm.nih.gov\/books\/NBK482326\/"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.06.002"},{"key":"e_1_3_4_6_1","unstructured":"Osteoarthritis Research Society International. Definition of OA: OARSI. 2025 Oct 21. Available from: https:\/\/oarsi.org\/research\/standardization-osteoarthritis-definitions"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.03.036"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jisakos-2015-000002"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7542.639"},{"key":"e_1_3_4_10_1","unstructured":"Swarup S Ahmed I Grigorova Y et al. Metabolic syndrome. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan [updated 2024 Mar 7]. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459248\/"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24008"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12413"},{"issue":"6","key":"e_1_3_4_13_1","first-page":"e86284","article-title":"Shared mechanisms between osteoarthritis and cardiovascular disease: a clinical and pathophysiological review","volume":"17","author":"Khan M","year":"2025","unstructured":"Khan M, Siddiqui T, Siddiqui R, et al. Shared mechanisms between osteoarthritis and cardiovascular disease: a clinical and pathophysiological review. Cureus. 2025 Jun 18;17(6):e86284.","journal-title":"Cureus"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.03.005"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39672"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-017-0941-0"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53812-2"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201178"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev106"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2025.03.003"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199808)41:8<1343::AID-ART3>3.0.CO;2-9"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.05.015"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X09342132"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801585"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.04.006"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00847-5"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(17)30074-9"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab454"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.06.005"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.136"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10051109"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00301-9"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-025-06140-0"},{"key":"#cr-split#-e_1_3_4_34_1.1","unstructured":"Australian Institute of Health and Welfare (2024) Osteoarthritis A Australian Government. Osteoarthritis. Canberra: AIHW"},{"key":"#cr-split#-e_1_3_4_34_1.2","unstructured":"2024 [cited 2025 18]. Available from: https:\/\/www.aihw.gov.au\/reports\/chronic-musculoskeletal-conditions\/osteoarthritis"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2025.08.015"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-225324"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.07.015"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00163-7"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0324296"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02322-5"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei049"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.72"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1012087"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex417"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.12.016"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.09.013"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"e_1_3_4_49_1","volume-title":"Osteoarthritis","author":"Hunter DJ","year":"2014","unstructured":"Hunter DJ, Prieto-Alhambra D, Arden N. Osteoarthritis. Oxford University Press; 2014."},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.05.016"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.11.016"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2010.11.001"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002624"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339709790192440"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2023.100405"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102572"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3555"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30360"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190925163827"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.39.6.7596"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2025.101337"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32831bc0d7"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155043"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0095-4"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312669"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559827609332737"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X20981219"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11081312"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.12.016"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030125"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.06.005"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.08.005"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091486"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.5.E685"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/1547691X.2021.1959677"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21199"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00434-8"},{"issue":"10","key":"e_1_3_4_78_1","first-page":"2099","article-title":"Knee osteoarthritis clinical practice guidelines \u2013 how are we doing?","volume":"34","author":"DeHaan MN","year":"2007","unstructured":"DeHaan MN, Guzman J, Bayley MT, et al. Knee osteoarthritis clinical practice guidelines \u2013 how are we doing? J Rheumatol. 2007;34(10):2099\u20132105.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.009431"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.02.005"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019694"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-48"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280701774233"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.02.428"},{"issue":"9","key":"e_1_3_4_85_1","first-page":"1827","article-title":"Effects of training on general practitioners\u2019 management of pain in osteoarthritis: a randomized multicenter study","volume":"33","author":"Chassany O","year":"2006","unstructured":"Chassany O, Boureau F, Liard F, et al. Effects of training on general practitioners\u2019 management of pain in osteoarthritis: a randomized multicenter study. J Rheumatol. 2006;33(9):1827\u20131834.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-018-0715-8"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25313"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzi016"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304053"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1253267"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00547-x"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111734"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-55374-1"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195489"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12912-021-00684-2"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16223873"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7234.569"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7234.526"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-024-02309-4"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22805"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12726"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23608"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.10.013"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00346-2"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000202"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa673"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403664"},{"key":"e_1_3_4_108_1","unstructured":"Subcutaneous tirzepatide once-weekly in patients with obesity and knee osteoarthritis (STOP KNEE-OA) (STOP KNEE-OA). 2024. https:\/\/clinicaltrials.gov\/study\/NCT06191848"},{"key":"e_1_3_4_109_1","unstructured":"A study of retatrutide (LY3437943) once weekly in participants who have obesity or overweight and osteoarthritis of the knee (TRIUMPH-4). 2024. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05931367"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01209-2"},{"key":"e_1_3_4_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00523-9"},{"issue":"12","key":"e_1_3_4_112_1","first-page":"CD004376","article-title":"Exercise for osteoarthritis of the knee","volume":"12","author":"Lawford BJ","year":"2024","unstructured":"Lawford BJ, Hall M, Hinman RS, et al. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2024 Dec 3;12(12):CD004376.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001944"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671231172773"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200914"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105317733320"},{"key":"e_1_3_4_117_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671231152900"},{"key":"e_1_3_4_118_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"key":"e_1_3_4_119_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.576"},{"key":"e_1_3_4_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018487"},{"key":"e_1_3_4_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2023.04.002"},{"key":"e_1_3_4_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2017.08.008"},{"key":"e_1_3_4_123_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.40126"},{"key":"e_1_3_4_124_1","volume-title":"Osteoarthritis chronic care program: model of care","author":"Agency for Clinical Innovation (NSW)","year":"2019","unstructured":"Agency for Clinical Innovation (NSW). Osteoarthritis chronic care program: model of care. Sydney (AU): Agency for Clinical Innovation; 2019."},{"key":"e_1_3_4_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00594-6"},{"key":"e_1_3_4_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.09.005"},{"key":"e_1_3_4_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.08.047"},{"key":"e_1_3_4_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2023.101852"},{"key":"e_1_3_4_129_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2024.7"},{"key":"e_1_3_4_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-020-01326-0"},{"key":"e_1_3_4_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00697-6"},{"key":"e_1_3_4_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10996-1"},{"key":"e_1_3_4_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2024.01.003"},{"key":"e_1_3_4_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.04.026"},{"key":"e_1_3_4_135_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-035101"},{"key":"e_1_3_4_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2025.100677"},{"key":"e_1_3_4_137_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.14735"},{"issue":"5","key":"e_1_3_4_138_1","first-page":"847","article-title":"A phase 3, 28-week, multicentre, randomised, double-blind, placebo-controlled trial (OA-10) to evaluate the efficacy and safety of a single injection of lorecivivint in the target knee joint of moderately to severely symptomatic osteoarthritis patients","volume":"43","author":"Yazici Y","year":"2025","unstructured":"Yazici Y, Tambiah JRS, Swearingen CJ, et al. A phase 3, 28-week, multicentre, randomised, double-blind, placebo-controlled trial (OA-10) to evaluate the efficacy and safety of a single injection of lorecivivint in the target knee joint of moderately to severely symptomatic osteoarthritis patients. Clin Exp Rheumatol. 2025;43(5):847\u2013853.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41760"},{"key":"e_1_3_4_140_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.058347"},{"key":"e_1_3_4_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-019-3166-y"},{"key":"e_1_3_4_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10121051"},{"key":"e_1_3_4_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2008.07.011"},{"key":"e_1_3_4_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-17682-z"},{"key":"e_1_3_4_145_1","unstructured":"UK Biobank. Health reseach data for the world. Available from: https:\/\/www.ukbiobank.ac.uk"},{"key":"e_1_3_4_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01858.x"},{"key":"e_1_3_4_147_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003298"},{"key":"e_1_3_4_148_1","unstructured":"Clinical Practice Research Datalink. UK data driving real-world evidence. 2025 Nov 19. Available from: https:\/\/www.cprd.com\/data"},{"key":"e_1_3_4_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29581-1"},{"key":"e_1_3_4_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2021.100797"},{"key":"e_1_3_4_151_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S141295"},{"key":"e_1_3_4_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.04.013"},{"key":"e_1_3_4_153_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.191075"},{"issue":"1","key":"e_1_3_4_154_1","first-page":"172","article-title":"Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County osteoarthritis Project","volume":"34","author":"Jordan JM","year":"2007","unstructured":"Jordan JM, Helmick CG, Renner JB, et al. Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County osteoarthritis Project. J Rheumatol. 2007;34(1):172\u2013180.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24872"},{"key":"e_1_3_4_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_3_4_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.10.017"},{"key":"e_1_3_4_158_1","unstructured":"Australian Orthopaedic Association. The Australian orthopaedic association national joint replacement registry. 2025. Available from: https:\/\/aoanjrr.sahmri.com"},{"key":"e_1_3_4_159_1","unstructured":"Australia\u2019s national statistical agency. Australian Bureau of Statistics. 2022. Available from: https:\/\/www.abs.gov.au"},{"key":"e_1_3_4_160_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-080387"},{"key":"e_1_3_4_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24423"},{"issue":"155","key":"e_1_3_4_162_1","first-page":"1","article-title":"The national health and nutrition examination survey: sample design, 1999\u20132006","author":"Curtin LR","year":"2012","unstructured":"Curtin LR, Mohadjer LK, Dohrmann SM, et al. The national health and nutrition examination survey: sample design, 1999\u20132006. Vital Health Stat. 2012 May;(155):1\u201339.","journal-title":"Vital Health Stat"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2026.2649611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T18:13:47Z","timestamp":1775931227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2026.2649611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":161,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,3]]}},"alternative-id":["10.1080\/17512433.2026.2649611"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2026.2649611","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"value":"1751-2433","type":"print"},{"value":"1751-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}