{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:52:47Z","timestamp":1792050767454,"version":"4.4.0"},"reference-count":76,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2026,10,3]]},"DOI":"10.1080\/17512433.2026.2742318","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:26:25Z","timestamp":1791307585000},"page":"921-935","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Off-label drug use in children: prevalence, risks, and regulation"],"prefix":"10.1080","volume":"19","author":[{"given":"Antje","family":"Neubert","sequence":"first","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Eberl","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1284"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-20195-0_2"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2016.1198256"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112688"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14989"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.08.011"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.140023"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12750"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-631"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-005-1181-7"},{"key":"e_1_3_6_13_1","unstructured":"European Commission. Regulation (EC) No 1901\/2006 of the European Parliament and of the council on medicinal products for pediatric use 2006. Official journal of the European union. 2006 Dec 12 [cited 2025 Dec 10]. Available from: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX:32006R1901&qid=1621344437946"},{"key":"e_1_3_6_14_1","unstructured":"US Congress. Best pharmaceuticals for children act. Pub L No 107\u2013109. 2002 Jan 4 [cited 2025 Oct 12]. Available from: https:\/\/www.congress.gov\/107\/plaws\/publ109\/PLAW-107publ109.pdf"},{"key":"e_1_3_6_15_1","unstructured":"US Congress. Pediatric research equity act. Pub L No 108\u2013155. 2003 Dec 3 [cited 2025 Oct 12]. Available from: https:\/\/www.govinfo.gov\/content\/pkg\/PLAW-108publ155\/pdf\/PLAW-108publ155.pdf"},{"key":"e_1_3_6_16_1","unstructured":"European Medicines Agency and its Paediatric Committee. 10-year report to the European commission: General report on the experience acquired as a result of the application of the paediatric regulation. EMA\/231225\/2015 HumannMedicines research and development support Division; ref Ares(2016)6395061 - 14\/11\/2016. 2016 Oct 27 [accessed 2025\u201312-10]. https:\/\/health.ec.europa.eu\/document\/download\/cf6bdf31-ecb4-4376-9fb3-c5146e41d079_en"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1009432"},{"issue":"8","key":"e_1_3_6_18_1","first-page":"776","article-title":"Off-label medication use in children, more common than we think: a systematic review of the literature","volume":"111","author":"Allen HC","year":"2018","unstructured":"Allen HC, Garbe MC, Lees J, et al. Off-label medication use in children, more common than we think: a systematic review of the literature. J Okla State Med Assoc. 2018;111(8):776\u2013783.","journal-title":"J Okla State Med Assoc"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12402"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-018-0186-y"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-20.4.316"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574884712666170317161935"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1768-9"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2018.02.002"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15122652"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-021-00430-3"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2024.12701"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/2168479016651470"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5640"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-021-01303-5"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-24-198"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-022-03457-1"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.892574"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph181910447"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03556-9"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1886-z"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2736"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.12.011"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-016-0558-3"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-017-1045-y"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13394"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.09.007"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1097-1"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-238"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.t01-3-01689.x"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0543-1"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb00191.x"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200427130-00006"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0764"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.843"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12065"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12222"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.12431"},{"key":"e_1_3_6_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3181e057e1"},{"key":"e_1_3_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12541"},{"key":"e_1_3_6_56_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e227"},{"key":"e_1_3_6_57_1","doi-asserted-by":"publisher","DOI":"10.3233\/JRS-150642"},{"key":"e_1_3_6_58_1","unstructured":"European Medicines Agency. Pre-authorisation evaluation of medicines for human use. Evidence of harm from off-label or unlicensed medicines in children. EMEA\/126327\/2004. 2004 Oct [cited 2026 Jul 31]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/other\/evidence-harm-label-or-unlicensed-medicines-children_en.pdf"},{"key":"e_1_3_6_59_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-4060"},{"key":"e_1_3_6_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.593281"},{"key":"e_1_3_6_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1473862"},{"key":"e_1_3_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12119"},{"key":"e_1_3_6_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13040588"},{"key":"e_1_3_6_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy8030173"},{"key":"e_1_3_6_65_1","doi-asserted-by":"publisher","DOI":"10.57598\/R252C"},{"key":"e_1_3_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.04.017"},{"key":"e_1_3_6_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-022-01418-7"},{"key":"e_1_3_6_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2336"},{"key":"e_1_3_6_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy9010008"},{"key":"e_1_3_6_70_1","unstructured":"SwissPedDose [Internet]. Z\u00fcrich: SwissPedDose; [cited 2026 Jul 31]. Available from: https:\/\/db.swisspeddose.ch\/"},{"key":"e_1_3_6_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311674"},{"key":"e_1_3_6_72_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.9.1021"},{"key":"e_1_3_6_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-014-0468-y"},{"key":"e_1_3_6_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/21.2.83"},{"key":"e_1_3_6_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.16.2114"},{"key":"e_1_3_6_76_1","unstructured":"Kinderformularium.DE [Internet]. Erlangen: Universit\u00e4tsklinikum Erlangen; [cited 2026 Jul 31]. Available from: https:\/\/kinderformularium.de\/"},{"key":"e_1_3_6_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0707400"},{"key":"e_1_3_6_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-013-2926-3"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2026.2742318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/17512433.2026.2742318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2026.2742318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:16:29Z","timestamp":1792048589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2026.2742318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":76,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,3]]}},"alternative-id":["10.1080\/17512433.2026.2742318"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2026.2742318","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"value":"1751-2433","type":"print"},{"value":"1751-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}