{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:49:35Z","timestamp":1791362975360,"version":"4.3.1"},"reference-count":67,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"DOI":"10.1080\/17512433.2026.2744573","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:51:50Z","timestamp":1791143510000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Disitamab vedotin in urothelial carcinoma patients: a clinical trial perspective from ARON working group"],"prefix":"10.1080","author":[{"given":"Concetta","family":"Calabr\u00f2","sequence":"first","affiliation":[{"name":"Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Istituto Tumori Giovanni Paolo II-Bari","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ciccimarra","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Milella","sequence":"additional","affiliation":[{"name":"I.R.C.C.S. Istituto Tumori \u201cGiovanni Paolo II\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Cazzato","sequence":"additional","affiliation":[{"name":"University of Bari \u201cAldo Moro\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Della Mura","sequence":"additional","affiliation":[{"name":"University of Bari \u201cAldo Moro\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Palermo","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d Bari","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jure","family":"Murgi\u0107","sequence":"additional","affiliation":[{"name":"University Hospital Center \u201cSestre Milosrdnice\u201d","place":["Zagreb, Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Szarvas","sequence":"additional","affiliation":[{"name":"Semmelweis University","place":["Budapest, Hungary"]},{"name":"University Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-6503","authenticated-orcid":false,"given":"Kannan","family":"Sridharan","sequence":"additional","affiliation":[{"name":"Arabian Gulf University","place":["Manama, Kingdom of Bahrain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza","family":"Nieto-Coronel","sequence":"additional","affiliation":[{"name":"Medical Oncology Departament","place":["La Paz City, Bolivia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aly-Khan A.","family":"Lalani","sequence":"additional","affiliation":[{"name":"McMaster University","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Mukuku","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur Des Techniques M\u00e9dicales","place":["Lubumbashi, Democratic Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Zayed","sequence":"additional","affiliation":[{"name":"King Hussein Cancer Center","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia","family":"Gauna","sequence":"additional","affiliation":[{"name":"Instituto Nacional del C\u00e1ncer","place":["Capiat\u00e1, Paraguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Paciolla","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Massafra","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oronzo","family":"Brunetti","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Mollica","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","place":["Bologna, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-6871","authenticated-orcid":false,"given":"Francesco","family":"Massari","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","place":["Bologna, Italy"]},{"name":"University of Bologna","place":["Bologna, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Santoni","sequence":"additional","affiliation":[{"name":"Macerata Hospital","place":["Macerata, Italy"]},{"name":"ARON Research Foundation ETS","place":["Macerata, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rizzo","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.03.001"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.08.001"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-026-16109-9"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-025-02020-3"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312117"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2026.22"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107543"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.70130"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-025-01075-x"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1326296"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.09.006"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61101759"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16183145"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1871-x"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02912"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1230395"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16173071"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.704683"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407715"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2511648"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2025.100637"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2025.2535280"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01614-x"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2025.2533488"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.6_suppl.TPS594"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2026.44.7_suppl.LBA631"},{"key":"e_1_3_5_30_1","doi-asserted-by":"crossref","first-page":"S1138","DOI":"10.1016\/j.annonc.2024.08.2052","article-title":"Mo Preliminary efficacy and safety of disitamab vedotin (DV) with pembrolizumab (P) in treatment (tx)-naive HER2-expressing, locally advanced or metastatic urothelial carcinoma (la\/mUC): RC48G001 cohort C","volume":"35","author":"Galsky M","year":"1967","unstructured":"Galsky M, Koshkin V, Campbell M. Mo Preliminary efficacy and safety of disitamab vedotin (DV) with pembrolizumab (P) in treatment (tx)-naive HER2-expressing, locally advanced or metastatic urothelial carcinoma (la\/mUC): RC48G001 cohort C. Ann Oncol. 1967;35:S1138\u2013S1139.","journal-title":"Ann Oncol"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.10.352"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.02.019"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0024"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106106"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.5548"},{"key":"e_1_3_5_36_1","unstructured":"ClinicalTrials.gov. Study record: NCT05979740 \u2013 RC48 ADC combined with toripalimab and radiotherapy for muscle invasive bladder cancer. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05979740"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2023-6685"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2025.101216"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102415"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2069883"},{"key":"e_1_3_5_41_1","unstructured":"ClinicalTrials.gov. Study evaluating disitamab vedotin combined with pd\u20111 inhibitor and radiotherapy as bladder\u2011preserving therapy in HER2\u2011high MIBC (NCT07142200). U.S. National Library of Medicine. cited 2026 May 13]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT07142200"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.08.2069"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.10.009"},{"key":"e_1_3_5_44_1","unstructured":"ClinicalTrials.gov. A clinical study of disitamab vedotin for injection combined with penpulimab injection in neoadjuvant therapy for patients with HER2-expressing cisplatin-intolerant cT2\u2013T4aNxM0 bladder urothelial carcinoma. Identifier: NCT05488353. [cited 2022 Aug 4. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05488353"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2026.44.7_suppl.765"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-025-05829-5"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1363851"},{"key":"e_1_3_5_48_1","unstructured":"ClinicalTrials.gov Identifier: NCT07498907. Disitamab vedotin plus radiotherapy for adjuvant treatment of HER2-expressing cisplatin-ineligible upper tract urothelial carcinoma (LUXUS41). [cited 2026 May 15]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT07498907"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.e16583"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.4590"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02751-5"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.5_suppl.775"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.e16596"},{"key":"e_1_3_5_54_1","volume-title":"Presented at: 2026 European Association of Urology (EAU) Annual Meeting","author":"Shen YJ","year":"2026","unstructured":"Shen YJ. A phase iii, randomized, open-label trial of Disitamab Vedotin (DV) plus bacillus Calmette\u2013Gu\u00e9rin (BCG) in BCG-Na\u00efve patients with HER2-expressing high-risk non\u2013muscle invasive bladder cancer (HERO). In: Presented at: 2026 European Association of Urology (EAU) Annual Meeting; London, (UK); 2026 Mar 13\u201316."},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.3685"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(26)00810-9"},{"key":"e_1_3_5_57_1","unstructured":"ClinicalTrials.gov. Multimodal kidney-sparing strategy for high-risk upper tract urothelial carcinoma. Identifier: NCT07504939. cited 2026 May 14]. Available from: https:\/\/trial.medpath.com\/clinical-trial\/fd168bd8b0e7fa4d\/nct07504939-kidney-sparing-endoscopic-surgery-adjuvant-radiotherapy-her2-antibody-drug-conjugate"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.12.002"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2021.115534"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107778"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2024.12.006"},{"key":"e_1_3_5_62_1","unstructured":"Bourlon MT Valdez P Powles T et al. Optimizing treatment strategies for advanced urothelial cancer: what comes after frontline enfortumab vedotin and pembrolizumab? OncLive. Published February 27 2025. cited 2026 May 15]. Available from: https:\/\/www.onclive.com\/view\/optimizing-treatment-strategies-for-advanced-urothelial-cancer-what-comes-after-frontline-enfortumab-vedotin-and-pembrolizumab"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000938"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2025.1612181"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2025.06.13"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2025.101253"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.3523"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-24-354"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.71289"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2026.2744573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/17512433.2026.2744573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17512433.2026.2744573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:55:30Z","timestamp":1791359730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17512433.2026.2744573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":67,"alternative-id":["10.1080\/17512433.2026.2744573"],"URL":"https:\/\/doi.org\/10.1080\/17512433.2026.2744573","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"value":"1751-2433","type":"print"},{"value":"1751-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}