{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:18:36Z","timestamp":1789543116310,"version":"build-2803163510"},"reference-count":55,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002426","name":"This work was supported by Fondazione Telethon","doi-asserted-by":"publisher","award":["GGP10208; GSP14001; GSP18001; GSP21002"],"award-info":[{"award-number":["GGP10208; GSP14001; GSP18001; GSP21002"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Prion"],"published-print":{"date-parts":[[2022,12,31]]},"DOI":"10.1080\/19336896.2022.2083435","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T13:59:09Z","timestamp":1655992749000},"page":"66-77","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Preventive pharmacological treatment in subjects at risk for fatal familial insomnia: science and public engagement"],"prefix":"10.1080","volume":"16","author":[{"given":"Gianluigi","family":"Forloni","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Roiter","sequence":"additional","affiliation":[{"name":"Ulss 2 Marca Trevigiana Ca\u2019 Foncello Hospital, Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimiro","family":"Artuso","sequence":"additional","affiliation":[{"name":"Ulss 2 Marca Trevigiana Ca\u2019 Foncello Hospital, Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Marcon","sequence":"additional","affiliation":[{"name":"AFIFF, Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Colesso","sequence":"additional","affiliation":[{"name":"AFIFF, Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elviana","family":"Luban","sequence":"additional","affiliation":[{"name":"AFIFF, Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Lucca","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Tettamanti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Pupillo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Redaelli","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico \u201dCarlo Besta\u201d, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mariuzzo","sequence":"additional","affiliation":[{"name":"AFIFF, Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Boscolo Buleghin","sequence":"additional","affiliation":[{"name":"AFIFF, Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Mariuzzo","sequence":"additional","affiliation":[{"name":"AFIFF, Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Tagliavini","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico \u201dCarlo Besta\u201d, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"Fondazione Telethon ETS, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63945-5.00015-5"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2019.04.019"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1080\/19336896.2015.1027857"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201607293"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007745"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198610163151605"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1987.tb00812.x"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1038\/376434a0"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202133260704"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.669"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90360-3"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81163-0"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.1999.00005.x"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100490"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3840"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162195499"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001888"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.252064"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1039\/C0OB00303D"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.2174\/1871526510909010023"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00738"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.06.002"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1913-1"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01847-8"},{"key":"cit0025","doi-asserted-by":"crossref","first-page":"T149","DOI":"10.1016\/j.jalz.2008.05.373","volume":"4","author":"Tagliavini F","year":"2008","journal-title":"Alzheimers Dement"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313541"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70307-7"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2002.00941.x"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1159\/000101726"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.3109\/09546631003762639"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315200"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.65"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1038\/35081095"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001217"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1038\/srep46269"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009183"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063093"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1038\/nature01457"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1002\/cpsc.48"},{"key":"cit0041","first-page":"4327","volume":"31","author":"Sommer AG","year":"2012","journal-title":"J Vis Exp"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.116"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-019-01092-9"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2012.01900.x"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2013-000790"},{"key":"cit0046","first-page":"1","volume":"6","author":"Decruyenaere M","year":"1995","journal-title":"Genet Couns"},{"key":"cit0047","first-page":"897","volume":"36","author":"Decruyenaere M","year":"1999","journal-title":"J Med Genet"},{"key":"cit0048","first-page":"375","volume-title":"Paradigms in theory construction","author":"Colesso W","year":"2010"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.64.8.779"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2019.06.017"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S232499"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1007\/s43441-021-00282-z"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4891"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2552"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.1.73"}],"container-title":["Prion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19336896.2022.2083435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T06:47:26Z","timestamp":1671086846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19336896.2022.2083435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,31]]}},"alternative-id":["10.1080\/19336896.2022.2083435"],"URL":"https:\/\/doi.org\/10.1080\/19336896.2022.2083435","relation":{},"ISSN":["1933-6896","1933-690X"],"issn-type":[{"value":"1933-6896","type":"print"},{"value":"1933-690X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kprn20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kprn20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}