{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:02:36Z","timestamp":1783026156587,"version":"3.54.6"},"reference-count":50,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the open fund of the Key Laboratory of gastrointestinal tumor diagnosis and treatment of the National Health Commission","award":["NLDTG2020012"],"award-info":[{"award-number":["NLDTG2020012"]}]},{"name":"the Shenzhen Collaborative Innovation Technology Plan","award":["2022420667"],"award-info":[{"award-number":["2022420667"]}]},{"name":"the Shenzhen Science and Technology Program","award":["JCYJ20250604190013017"],"award-info":[{"award-number":["JCYJ20250604190013017"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Cell Adhesion & Migration"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/19336918.2026.2620945","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:25:56Z","timestamp":1769862356000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["COPB2 drives gastric cancer progression via PI3K\/AKT\/NF-\u03baB signaling: a multi-omics and functional study"],"prefix":"10.1080","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5972-907X","authenticated-orcid":false,"given":"Hailong","family":"Li","sequence":"first","affiliation":[{"name":"Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine","place":["Shenzhen, Guangdong Province, P. R. China"]},{"name":"Gansu Provincial Hospital","place":["Lanzhou, P. R. China"]},{"name":"Gansu University of Chinese Medicine","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wei","sequence":"additional","affiliation":[{"name":"Luohu District Traditional Chinese Medicine Hospital","place":["Shenzhen, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Su","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Yang","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Tang","sequence":"additional","affiliation":[{"name":"Shantou University","place":["Shenzhen, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqiu","family":"Yu","sequence":"additional","affiliation":[{"name":"Luohu District People\u2019s Hospital","place":["Shenzhen, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Shenzhen University","place":["Shenzhen, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00726-3"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00747-0"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i16.2452"},{"issue":"7","key":"e_1_3_5_5_1","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1002\/j.1460-2075.1993.tb05945.x","article-title":"Beta\u2019-COP, a novel subunit of coatomer","volume":"12","author":"Stenbeck G","year":"1993","unstructured":"Stenbeck G, Harter C, Brecht A, et al. Beta\u2019-COP, a novel subunit of coatomer. Embo J. 1993 Jul;12(7):2841\u20132845.","journal-title":"Embo J"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.918382"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102663"},{"issue":"1","key":"e_1_3_5_8_1","first-page":"777","article-title":"COPB2 suppresses cell proliferation and induces cell cycle arrest in human colon cancer by regulating cell cycle-related proteins","volume":"15","author":"Wang Y","year":"2018","unstructured":"Wang Y, Chai Z, Wang M, et al. COPB2 suppresses cell proliferation and induces cell cycle arrest in human colon cancer by regulating cell cycle-related proteins. Exp Ther Med. 2018 Jan;15(1):777\u2013784.","journal-title":"Exp Ther Med"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.040"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2016.09.005"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2019.4717"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2018.12.18"},{"issue":"5","key":"e_1_3_5_13_1","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1158\/1078-0432.CCR-08-2459","article-title":"Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma","volume":"15","author":"Erdogan E","year":"2009","unstructured":"Erdogan E, Klee EW, Thompson EA, et al. Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma. Clin Cancer Res. 2009 Mar 1;15(5):1527\u20131533.","journal-title":"Clin Cancer Res"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx247"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.02.003"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S171716"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2016.12.010"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1148-5"},{"issue":"1","key":"e_1_3_5_19_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20180617","article-title":"Prognostic values of inhibitory kappaB kinases mRNA expression in human gastric cancer","volume":"39","author":"Gayed DT","year":"2019","unstructured":"Gayed DT, Wodeyar J, Wang ZX, et al. Prognostic values of inhibitory kappaB kinases mRNA expression in human gastric cancer. Biosci Rep. 2019 Jan 31;39(1):1\u20139.","journal-title":"Biosci Rep"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.29252\/ibj.22.4.217"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.01.110"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201600099"},{"issue":"1","key":"e_1_3_5_23_1","first-page":"3","article-title":"Targeting HIF-1alpha signaling pathway for gastric cancer treatment","volume":"74","author":"Li H","year":"2019","unstructured":"Li H, Jia Y, Wang Y. Targeting HIF-1alpha signaling pathway for gastric cancer treatment. Pharmazie. 2019 Jan 1;74(1):3\u20137.","journal-title":"Pharmazie"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102329"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3668-8"},{"issue":"4","key":"e_1_3_5_26_1","first-page":"532","article-title":"Expressions of Slug, ZEB1 and KISS-1 in gastric adenocarcinoma and their clinical significance","volume":"36","author":"Zhou L","year":"2016","unstructured":"Zhou L, Hu YL, Wu SW, et al. Expressions of Slug, ZEB1 and KISS-1 in gastric adenocarcinoma and their clinical significance. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Apr;36(4):532\u2013537.","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20082"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2007.05.005"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-017-0705-x"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00851"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5604702"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3460"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22891"},{"issue":"10","key":"e_1_3_5_34_1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3748\/wjg.v24.i10.1120","article-title":"Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial\u2013mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma","volume":"24","author":"Sun L","year":"2018","unstructured":"Sun L, Li PB, Yao YF, et al. Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial\u2013mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. World J Gastroenterol. 2018 Mar 14;24(10):1120\u20131133.","journal-title":"World J Gastroenterol"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357907.2017.1378671"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.04.008"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9600"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.5301\/jbm.5000184"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.05.002"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2014.11.010"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2018.06.005"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.11.028"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7508"},{"issue":"1","key":"e_1_3_5_44_1","first-page":"129","article-title":"Clinicopathological correlations of autophagy-related proteins LC3, Beclin 1 and p62 in gastric cancer","volume":"36","author":"Masuda GO","year":"2016","unstructured":"Masuda GO, Yashiro M, Kitayama K, et al. Clinicopathological correlations of autophagy-related proteins LC3, Beclin 1 and p62 in gastric cancer. Anticancer Res. 2016 Jan;36(1):129\u2013136.","journal-title":"Anticancer Res"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13886"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1043-0"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26524"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3851-y"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168085"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2018.6348"},{"issue":"9","key":"e_1_3_5_51_1","first-page":"551","article-title":"Expression of NFkappaB p65 and its target genes in gastric cancer and precancerous lesions","volume":"26","author":"Yang GF","year":"2004","unstructured":"Yang GF, Deng CS, Xiong YY, et al. Expression of NFkappaB p65 and its target genes in gastric cancer and precancerous lesions. Zhonghua Zhong Liu Za Zhi. 2004 Sep;26(9):551\u2013553.","journal-title":"Zhonghua Zhong Liu Za Zhi"}],"container-title":["Cell Adhesion & Migration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19336918.2026.2620945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:25:58Z","timestamp":1769862358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19336918.2026.2620945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/19336918.2026.2620945"],"URL":"https:\/\/doi.org\/10.1080\/19336918.2026.2620945","relation":{},"ISSN":["1933-6918","1933-6926"],"issn-type":[{"value":"1933-6918","type":"print"},{"value":"1933-6926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kcam20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kcam20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2620945"}}