{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:56:34Z","timestamp":1793706994479,"version":"4.6.1"},"reference-count":84,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Channels"],"published-print":{"date-parts":[[2021,1,1]]},"DOI":"10.1080\/19336950.2020.1860382","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T23:58:34Z","timestamp":1610582314000},"page":"193-207","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":23,"title":["Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides"],"prefix":"10.1080","volume":"15","author":[{"given":"Robert A.","family":"Neff","sequence":"first","affiliation":[{"name":"Neuroscience Discovery, Janssen Research and Development, LLC, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Wickenden","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Pharmacology, Janssen Research and Development, LLC, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.20.2435"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.2174\/1389450043345227"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01633.x"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41340"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.187807"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1527"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152405"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.012153"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.10.006"},{"key":"cit0010","first-page":"429","volume":"130","author":"Legroux-Crespel E","year":"2003","journal-title":"Annales de dermatologie et de venereologie"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000205"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913181107"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21895"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-23"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1038\/nature05413"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00790.x"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1177\/1744806920923881"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-018-0643-4"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21325"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1159\/000314692"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.016"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.09.007"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2642.1"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm160"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12123"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12280"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.07.003"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1038\/nature09975"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13096"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182904fdd"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105895"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404915101"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1795"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01906"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.064"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2017.1377613"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11110626"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11100611"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1590\/1678-9199-jvatitd-14-63-18"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01000"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2122851"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.04.337"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00366"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204063200"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.015941"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1038\/srep40883"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1021\/bi026546a"},{"key":"cit0048","unstructured":"NCBI:txid29017, NCBI Taxonomy Browser, 1 Dec. 2020, <https:\/\/www.ncbi.nlm.nih.gov\/Taxonomy\/Browser\/wwwtax.cgi>"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708447200"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.03.011"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.461392"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173551"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)49888-7"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.05.015"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.01.020"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.047"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.012281"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2493"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.10.011"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922903117"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.033"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1021\/jm501765v"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01947"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00542"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8030078"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14461"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.725978"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.06.052"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001567"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00002"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.047670"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.066332"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120800109"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-82"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1038\/srep39662"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1021\/jm500687u"},{"key":"cit0077","unstructured":"Flinspach M, Neff R, Liu Y, et al. Protoxin-II variants and methods of use. US20150099705. 2015."},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.17265\/2159-5313\/2016.09.003"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03584304"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196791"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00495"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00736"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.568642"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b00183"}],"container-title":["Channels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19336950.2020.1860382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T18:41:26Z","timestamp":1639334486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19336950.2020.1860382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,1]]}},"alternative-id":["10.1080\/19336950.2020.1860382"],"URL":"https:\/\/doi.org\/10.1080\/19336950.2020.1860382","relation":{},"ISSN":["1933-6950","1933-6969"],"issn-type":[{"value":"1933-6950","type":"print"},{"value":"1933-6969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kchl20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kchl20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}