{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:00:41Z","timestamp":1792792841294,"version":"4.5.0"},"reference-count":70,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Interdisciplinary Centre for Clinical Research RWTH Aachen University","id":[{"id":"https:\/\/ror.org\/04xfq0f34","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Channels"],"published-print":{"date-parts":[[2021,1,1]]},"DOI":"10.1080\/19336950.2020.1870087","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T04:38:32Z","timestamp":1611549512000},"page":"208-228","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect"],"prefix":"10.1080","volume":"15","author":[{"given":"Kim","family":"Le Cann","sequence":"first","affiliation":[{"name":"Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannis E.","family":"Meents","sequence":"additional","affiliation":[{"name":"Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Sudha Bhagavath Eswaran","sequence":"additional","affiliation":[{"name":"Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike F.","family":"Dohrn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raya","family":"Bott","sequence":"additional","affiliation":[{"name":"Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bialer","sequence":"additional","affiliation":[{"name":"Division of Clinical Metabolism of Medical Genetics and Human Genomics at Northwell Health System, New-York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hautvast","sequence":"additional","affiliation":[{"name":"Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andelain","family":"Erickson","sequence":"additional","affiliation":[{"name":"Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Rolke","sequence":"additional","affiliation":[{"name":"Department for Palliative Care, Medical Faculty, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Rothermel","sequence":"additional","affiliation":[{"name":"Department of Chemosensation, AG Neuromodulation, Institute for Biology II, RWTH Aachen University, Aachen, 52074, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannis","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany"},{"name":"Department of Anaesthesiology, Medical Faculty, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Kurth","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Lampert","sequence":"additional","affiliation":[{"name":"Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-3-207"},{"key":"cit0002","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/nature05441","volume":"444","author":"Cox JJ","year":"2006","journal-title":"Nature"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2695-04.2004"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.10.006"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22485"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-016-0556-x"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041750"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.242370"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1272"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2014.09.002"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12071"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1186\/s12918-016-0382-0"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0347-1"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2493"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp033"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.3"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015146710500"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2019.183129"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2011.00070"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1038\/nature26137"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0779-3"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr143"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh514"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000231514.33603.1e"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1038\/srep25974"},{"key":"cit0026","first-page":"1","author":"Lampert A","year":"2015","journal-title":"eLS"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-23"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2016-011244"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607637200"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802900200"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.200915"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184572"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00065-5"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1385\/CBB:35:2:171"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2011.00053"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_75"},{"key":"cit0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2013.00137","volume":"7","author":"Laedermann CJ","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.224204"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.09.018"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3404"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406387200"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15196"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01350.2007"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0462-16.2016"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.4161\/chan.3.2.7932"},{"key":"cit0046","author":"Jo HG","year":"2020","journal-title":"Brain Imaging Behav"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1038\/nature09975"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053114"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx326"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww007"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay6848"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913181107"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319042"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3411-9_3"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70150-4"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02262-0"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001973"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.11.047"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1113\/JP272237"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00524.2018"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182574f12"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws187"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161789"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.502211"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001511"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1529"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.07.010"},{"key":"cit0069","author":"Kerth CM","journal-title":"J Biol Chem"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp078"}],"container-title":["Channels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19336950.2020.1870087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T13:46:21Z","timestamp":1639316781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19336950.2020.1870087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,1]]}},"alternative-id":["10.1080\/19336950.2020.1870087"],"URL":"https:\/\/doi.org\/10.1080\/19336950.2020.1870087","relation":{},"ISSN":["1933-6950","1933-6969"],"issn-type":[{"value":"1933-6950","type":"print"},{"value":"1933-6969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kchl20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kchl20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}