{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:13:02Z","timestamp":1781075582569,"version":"3.54.1"},"reference-count":48,"publisher":"Informa UK Limited","issue":"2","funder":[{"name":"the Faculty of Natural Sciences, University of Tirana"},{"name":"the Food Safety and Veterinary Institute, for their support and provision of resources throughout the course of this study"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Food Additives &amp; Contaminants: Part B"],"published-print":{"date-parts":[[2025,4,3]]},"DOI":"10.1080\/19393210.2025.2457134","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T09:43:20Z","timestamp":1738143800000},"page":"143-154","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":5,"title":["Nitroimidazoles in Albanian honey samples by LC-MS\/MS analysis"],"prefix":"10.1080","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3448-9148","authenticated-orcid":false,"given":"Ina","family":"Pasho","sequence":"first","affiliation":[{"name":"University of Tirana","place":["Tirana, Albania"]},{"name":"Novartis Pharma Albania & Kosovo & North Macedonia","place":["Tirana, Albania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozeta","family":"Vaso","sequence":"additional","affiliation":[{"name":"University of Tirana","place":["Tirana, Albania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landi","family":"Dardha","sequence":"additional","affiliation":[{"name":"Ariel University","place":["Ariel, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.07.066"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.0285"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.03.174"},{"issue":"25","key":"e_1_3_3_5_1","first-page":"7661","article-title":"Innovations in sample preparation and detection techniques for honey analysis: toward greener and more efficient methodologies","volume":"70","author":"Bansal V","year":"2022","unstructured":"Bansal V, Kim KH. 2022. Innovations in sample preparation and detection techniques for honey analysis: toward greener and more efficient methodologies. J Agric Food Chem. 70(25):7661\u20137672.","journal-title":"J Agric Food Chem"},{"key":"e_1_3_3_6_1","first-page":"116","article-title":"Advances in the QuEChERS method for pesticide and veterinary drug residue analysis in food matrices","volume":"158","author":"Cao X","year":"2022","unstructured":"Cao X, Wang Q. 2022. Advances in the QuEChERS method for pesticide and veterinary drug residue analysis in food matrices. Trends Analytical Chem. 158:116\u2013125.","journal-title":"Trends Analytical Chem"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.10.023"},{"key":"e_1_3_3_8_1","unstructured":"Codex Alimentarius Commission. 2013. Codex committee on residues of veterinary drugs in food. Discussion paper on guidelines on the establishment of MRLs or other limits in honey. Annex 1.Twenty-first session of the CCRVDF CX\/RVDF 13\/21\/12. www.codexalimentarius.org\/."},{"key":"e_1_3_3_9_1","unstructured":"Codex Alimentarius Commission. 2022. Standard for honey CXS 12-1981 latest amendment in 2022. www.codexalimentarius.org."},{"key":"e_1_3_3_10_1","unstructured":"Commission Implementing Regulation (EU) (EU) 2021\/808 of 22 March 2021 on the performance of analytical methods for residues of pharmacologically active substances used in food-producing animals and on the interpretation of results as well as on the methods to be used for sampling and repealing decisions 2002\/657\/EC and 98\/179\/EC OJ L 180 21.05.2021 L 180\/84\u2013109. https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/PDF\/?uri=CELEX:32021R0808."},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2017.05.012"},{"key":"e_1_3_3_12_1","unstructured":"Ellison Stephen LR Williams A. 2012. EURACHEM\/CITAC Guide CG 4 quantifying uncertainty in analytical measurement. 3rd ed. https:\/\/www.eurachem.org\/images\/stories\/Guides\/pdf\/QUAM2012_P1.pdf."},{"key":"e_1_3_3_13_1","unstructured":"EURL guidance on minimum method performance requirements (MMPRs) for specific pharmacologically active substances in specific animal matrices 2022. Standing Committee on Plants Animals Food and Feed section Novel Food and Toxicological Safety of the Food Chain. https:\/\/eurl-residues.eu\/wp-content\/uploads\/2022\/06\/EURL_MMPR_guidance_endorsed.pdf."},{"key":"e_1_3_3_14_1","unstructured":"European Commission. 2010. Commission regulation (EU) No 37\/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/PDF\/?uri=CELEX:32010R0037."},{"key":"e_1_3_3_15_1","first-page":"84","article-title":"Commission implementing regulation (EU) 2021\/808 of 22 March 2021 on the performance of analytical methods for residues of pharmacologically active substances used in food-producing animals and on the interpretation of results as well as on the methods to be used for sampling and repealing decisions 2002\/657\/EC and 98\/179\/EC","volume":"180","author":"European Commission","year":"2021","unstructured":"European Commission. 2021. Commission implementing regulation (EU) 2021\/808 of 22 March 2021 on the performance of analytical methods for residues of pharmacologically active substances used in food-producing animals and on the interpretation of results as well as on the methods to be used for sampling and repealing decisions 2002\/657\/EC and 98\/179\/EC. Off J Eur Union. 180:84\u201310.","journal-title":"Off J Eur Union"},{"issue":"18","key":"e_1_3_3_16_1","first-page":"20","article-title":"Commission regulation (EU) 2022\/2092 of 10 December 2022 on maximum residue levels for veterinary drug residues in foodstuffs","volume":"281","author":"European Commission","year":"2022","unstructured":"European Commission. 2022. Commission regulation (EU) 2022\/2092 of 10 December 2022 on maximum residue levels for veterinary drug residues in foodstuffs. Off J Eur Union. 281(18\u2013L281):20.","journal-title":"Off J Eur Union"},{"issue":"8","key":"e_1_3_3_17_1","first-page":"e06539","article-title":"EFSA opinion on nitroimidazole residues in food of animal origin and potential risks to human health","volume":"19","author":"European Food Safety Authority","year":"2021","unstructured":"European Food Safety Authority. 2021. EFSA opinion on nitroimidazole residues in food of animal origin and potential risks to human health. EFSA J. 19(8):e06539.","journal-title":"EFSA J"},{"key":"e_1_3_3_18_1","first-page":"1","article-title":"EURL guidance on minimum method performance requirements (MMPRs) for specific pharmacologically active substances in specific animal matrices","author":"European Reference Laboratory","year":"2020","unstructured":"European Reference Laboratory. 2020. EURL guidance on minimum method performance requirements (MMPRs) for specific pharmacologically active substances in specific animal matrices. Eur Union. 1\u20138. doi: https:\/\/eurl-residues.eu\/wp-content\/uploads\/2020\/12\/EURL_MMPR_.guidance-paper_final.pdf.","journal-title":"Eur Union"},{"key":"e_1_3_3_19_1","unstructured":"FAPAS. 2024. Food analysis performance assessment scheme. Proficiency testing report 02536 nitroimidazoles & aminoglycosides (streptomycin & dihydrostreptomycin) in honey. February-may 2024. Sand Hutton York YO41 1LZ (UK): The Food and Environment Research Agency."},{"key":"e_1_3_3_20_1","first-page":"130472","article-title":"Application of liquid chromatography-tandem mass spectrometry (LC-MS\/MS) for the detection of emerging contaminants in food: a review","volume":"365","author":"G\u00f3mez-Ramos MM","year":"2021","unstructured":"G\u00f3mez-Ramos MM, Ferrer I, Thurman EM. 2021. Application of liquid chromatography-tandem mass spectrometry (LC-MS\/MS) for the detection of emerging contaminants in food: a review. Food Chem. 365:130472.","journal-title":"Food Chem"},{"issue":"2","key":"e_1_3_3_21_1","first-page":"321","article-title":"Advances in LC-MS\/MS techniques for the detection of antimicrobial residues in honey: sensitivity and specificity improvements","volume":"415","author":"Gonz\u00e1lez-G\u00f3mez ME","year":"2023","unstructured":"Gonz\u00e1lez-G\u00f3mez ME, Escorial MC, Mart\u00ednez-Bueno MJ. 2023. Advances in LC-MS\/MS techniques for the detection of antimicrobial residues in honey: sensitivity and specificity improvements. Analytical Bioanal Chem. 415(2):321\u2013333.","journal-title":"Analytical Bioanal Chem"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2013.787653"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/revac-2023-0072"},{"key":"e_1_3_3_24_1","first-page":"462715","article-title":"Development and validation of a QuEChERS-LC-MS\/MS method for simultaneous determination of multiple nitroimidazole residues in honey","volume":"1662","author":"Hu X","year":"2022","unstructured":"Hu X, Fan L, Ren Q. 2022. Development and validation of a QuEChERS-LC-MS\/MS method for simultaneous determination of multiple nitroimidazole residues in honey. J Chromatogr A. 1662:462715.","journal-title":"J Chromatogr A"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/03067319.2024.2339456"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JFCA.2024.106299"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.20959\/wjpr202213-25467"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182017002025"},{"key":"e_1_3_3_29_1","first-page":"107","article-title":"Residues of veterinary drugs in honey: a review of recent findings and implications for food safety","volume":"150","author":"Martel A","year":"2023","unstructured":"Martel A, Vanhaecke L. 2023. Residues of veterinary drugs in honey: a review of recent findings and implications for food safety. Food Control. 150:107\u2013113.","journal-title":"Food Control"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2014.883522"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.5772\/67135"},{"key":"e_1_3_3_32_1","volume-title":"2nd International Conference on Scientific and Innovative Studies","author":"Pasho I","year":"2024","unstructured":"Pasho I, Vaso K, Aleksi P, Marku E, Pllaha E. 2024 Apr. Ensuring honey safety: Albania\u2019s regulatory framework for nitroimidazole compounds and beyond. 2nd International Conference on Scientific and Innovative Studies; ISBN: 978-625-6314-01-6; Konya, Turkey."},{"key":"e_1_3_3_33_1","volume-title":"4th International Conference on Innovative AcademicStudies (ICIAS)","author":"Pasho I","year":"2024","unstructured":"Pasho I, Vaso K, Dardha L, Marku E, Hoxha V. 2024. Mar 12\u201313 March 2024 \u2013 Detection and analysis of nitroimidazole residues in Albanian honey: implications for food safety and regulatory oversight. 4th International Conference on Innovative AcademicStudies (ICIAS); ISBN: 978-625-6530-93-5, Konya, Turkey."},{"issue":"2","key":"e_1_3_3_34_1","first-page":"112","article-title":"Nitroimidazoles: antimicrobial and antiparasitic applications in veterinary medicine","volume":"25","author":"Pavlovic R","year":"2023","unstructured":"Pavlovic R, DeCorte Z, Bosch L. 2023. Nitroimidazoles: antimicrobial and antiparasitic applications in veterinary medicine. Vet Ther. 25(2):112\u2013121.","journal-title":"Vet Ther"},{"issue":"2","key":"e_1_3_3_35_1","first-page":"245","article-title":"Veterinary drug residues in honey: implications for food safety and public health","volume":"60","author":"Pereira ER","year":"2021","unstructured":"Pereira ER, Silva RD. 2021. Veterinary drug residues in honey: implications for food safety and public health. J Apic Res. 60(2):245\u2013258.","journal-title":"J Apic Res"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/19393210.2024.2405998"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.12688\/openreseurope.17664.2"},{"issue":"4","key":"e_1_3_3_38_1","first-page":"355","article-title":"The role of nitroimidazoles in treating protozoal infections and concerns about carcinogenicity","volume":"40","author":"Rodrigues J","year":"2022","unstructured":"Rodrigues J, Almeida C, Tavares MA. 2022. The role of nitroimidazoles in treating protozoal infections and concerns about carcinogenicity. J Antimicrob Agents. 40(4):355\u2013364.","journal-title":"J Antimicrob Agents"},{"key":"e_1_3_3_39_1","first-page":"103700","article-title":"Carcinogenic and genotoxic potential of nitroimidazoles: implications for their use in veterinary and human medicine","volume":"96","author":"\u0160oji\u0107 BV","year":"2022","unstructured":"\u0160oji\u0107 BV, Petrovi\u0107 J, Deli\u0107 MR, Tomi\u0107 J. 2022. Carcinogenic and genotoxic potential of nitroimidazoles: implications for their use in veterinary and human medicine. Environ Toxicol Pharmacol. 96:103700.","journal-title":"Environ Toxicol Pharmacol"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.35248\/2157-7110.20.11.825"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.21577\/0103-5053.20240206"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.01.029"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.02.013"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.11159\/iccpe24.108"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20189"},{"key":"e_1_3_3_46_1","volume-title":"Guidelines on the use of antibiotics in food-producing animals and the prevention of antibiotic resistance","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. 2017. Guidelines on the use of antibiotics in food-producing animals and the prevention of antibiotic resistance. Switzerland: WHO Guidelines."},{"key":"e_1_3_3_47_1","first-page":"116975","article-title":"Challenges and advances in the analysis of trace contaminants in honey: focus on green analytical chemistry methods","volume":"158","author":"Wu Z","year":"2023","unstructured":"Wu Z, Wang S, Ye L. 2023. Challenges and advances in the analysis of trace contaminants in honey: focus on green analytical chemistry methods. TrAC Trends Analytical Chem. 158:116975.","journal-title":"TrAC Trends Analytical Chem"},{"key":"e_1_3_3_48_1","volume-title":"Encyclopedia of pharmacy practice and clinical pharmacy","author":"Zaidi STR","year":"2019","unstructured":"Zaidi STR, Weier NE. 2019. In: Encyclopedia of pharmacy practice and clinical pharmacy. Huddersfield (UK): Elsevier."},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40543-021-00268-4"}],"container-title":["Food Additives &amp; Contaminants: Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19393210.2025.2457134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T14:45:53Z","timestamp":1748961953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19393210.2025.2457134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4,3]]}},"alternative-id":["10.1080\/19393210.2025.2457134"],"URL":"https:\/\/doi.org\/10.1080\/19393210.2025.2457134","relation":{},"ISSN":["1939-3210","1939-3229"],"issn-type":[{"value":"1939-3210","type":"print"},{"value":"1939-3229","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tfab20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tfab20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}