{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:49:58Z","timestamp":1785307798295,"version":"3.55.0"},"reference-count":49,"publisher":"Informa UK Limited","issue":"3","funder":[{"name":"MedImmune, the global biologics R&D arm of AstraZeneca"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["mAbs"],"published-print":{"date-parts":[[2019,4,3]]},"DOI":"10.1080\/19420862.2019.1578611","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T23:30:57Z","timestamp":1551828657000},"page":"500-515","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":23,"title":["Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer"],"prefix":"10.1080","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-545X","authenticated-orcid":false,"given":"Jason B.","family":"White","sequence":"first","affiliation":[{"name":"Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Fleming","sequence":"additional","affiliation":[{"name":"Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-4025","authenticated-orcid":false,"given":"Luke","family":"Masterson","sequence":"additional","affiliation":[{"name":"Spirogen Ltd, QMB Innovation Center, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-6128","authenticated-orcid":false,"given":"Ben T.","family":"Ruddle","sequence":"additional","affiliation":[{"name":"Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Oncology Research, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9517-8116","authenticated-orcid":false,"given":"Christine","family":"Fazenbaker","sequence":"additional","affiliation":[{"name":"Oncology Research, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Strout","sequence":"additional","affiliation":[{"name":"Oncology Research, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Reed","sequence":"additional","affiliation":[{"name":"Biologics Safety Assessment, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Muniz-Medina","sequence":"additional","affiliation":[{"name":"Biosuperiors, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Howard","sequence":"additional","affiliation":[{"name":"Spirogen Ltd, QMB Innovation Center, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Dixit","sequence":"additional","affiliation":[{"name":"Biologics Safety Assessment, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herren","family":"Wu","sequence":"additional","affiliation":[{"name":"Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-2334","authenticated-orcid":false,"given":"Mary Jane","family":"Hinrichs","sequence":"additional","affiliation":[{"name":"Biologics Safety Assessment, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshou","family":"Gao","sequence":"additional","affiliation":[{"name":"Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-1646","authenticated-orcid":false,"given":"Nazzareno","family":"Dimasi","sequence":"additional","affiliation":[{"name":"Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1021\/ja00952a050"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.30.349"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510610"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150089"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-016-0418-0"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050311-201823"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1021\/tx00005a002"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2011.573477"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1021\/bi00354a009"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1021\/jm051199z"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1021\/ja902986x"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1021\/bi034313t"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1021\/jm001064n"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.04.006"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1021\/bi00250a011"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1039\/A809791G"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1021\/jm030897l"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00062"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0219"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.6b00995"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0825"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac9459"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0233"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0982"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0789"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1021\/bc200212a"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0536"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0343"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3212"},{"key":"CIT0030","volume-title":"Sequences of proteins of immunological interest","author":"Kabat EA","year":"1991","edition":"5"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.719"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-015-9552-6"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209124"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1021\/bc400217g"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1021\/bc7004329"},{"key":"CIT0036","first-page":"100","volume":"57","author":"Trail PA","year":"1997","journal-title":"Cancer Res"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.19449"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1021\/jm500552c"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1021\/bc500357n"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083865"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.032"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1021\/bc900315y"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1021\/bc025536j"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.11.023"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0641"},{"key":"CIT0046","author":"Lowe D","year":"2018","journal-title":"Sci Transl Med"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2018.08.004"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.08.032"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.025"}],"container-title":["mAbs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19420862.2019.1578611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T22:07:44Z","timestamp":1553119664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19420862.2019.1578611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,2,12]]},"published-print":{"date-parts":[[2019,4,3]]}},"alternative-id":["10.1080\/19420862.2019.1578611"],"URL":"https:\/\/doi.org\/10.1080\/19420862.2019.1578611","relation":{},"ISSN":["1942-0862","1942-0870"],"issn-type":[{"value":"1942-0862","type":"print"},{"value":"1942-0870","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kmab20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kmab20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}