{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:01:03Z","timestamp":1777654863053,"version":"3.51.4"},"reference-count":70,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["mAbs"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1080\/19420862.2020.1818436","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T15:02:31Z","timestamp":1600268551000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Targeted IgMs agonize ocular targets with extended vitreal exposure"],"prefix":"10.1080","volume":"12","author":[{"given":"Yvonne","family":"Chen","sequence":"first","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Paluch","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Zorn","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmila","family":"Rajan","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Leonard","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Estevez","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Brady","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Chiu","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Phung","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Famili","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-9714","authenticated-orcid":false,"given":"Minhong","family":"Yan","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ciferri","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa L.","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg A.","family":"Lazar","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Crowell","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Hass","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Agard","sequence":"additional","affiliation":[{"name":"Genentech Inc","place":["South San Francisco, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.477"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.12.039"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.02.034"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.006"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.217"},{"key":"e_1_3_5_7_1","unstructured":"National Academies of Sciences Engineering and Medicine Health and Medicine Division Board on Population Health and Public Health Practice Committee on Public Health Approaches to Reduce Vision Impairment and Promote Eye Health. Welp A Woodbury RB McCoy MA Teutsch SM. Making eye health a population health imperative: vision for tomorrow. Washington (DC): National Academies Press (US); 2016."},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1559-0275-11-29"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.6b00345"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218613"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32559-0"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.08.018"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.12.2381"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00025-6"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12224"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.275"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470080067031"},{"key":"e_1_3_5_18_1","first-page":"761","article-title":"Neoadjuvant therapy of gastric cancer with the human monoclonal IgM antibody SC-1: impact on the immune system","volume":"19","author":"Beutner U","year":"2008","unstructured":"Beutner U, Lorenz U, Illert B, Rott L, Timmermann W, Vollmers HP, M\u00fcller-Hermelink HK, Thiede A, Ulrichs K. Neoadjuvant therapy of gastric cancer with the human monoclonal IgM antibody SC-1: impact on the immune system. Oncol Rep. 2008;19:761\u201369.","journal-title":"Oncol Rep"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.117945"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.19909"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2019.1625662"},{"key":"e_1_3_5_22_1","article-title":"DR5 agonist activity of HexaBody-DR5\/DR5 (GEN1029) is potentiated by C1q and independent of Fc-gamma receptor binding in preclinical tumor models","volume":"79","author":"Overdijk MB","unstructured":"Overdijk MB, Strumane K, Ortiz Buijsse A, Vermot-Desroches C, Kroesm T, De Jong B, Hoevenaars N, Beurskens FJ, de Jong RN, Lingnau A, et al. DR5 agonist activity of HexaBody-DR5\/DR5 (GEN1029) is potentiated by C1q and independent of Fc-gamma receptor binding in preclinical tumor models. Canc Res. 2019;79(Supplement).","journal-title":"Canc Res"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.938"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.03.023"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.111"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500292200"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.02.001"},{"key":"e_1_3_5_28_1","volume-title":"Combination therapy with intravitreal nesvacumab and aflibercept for neovascular age-related macular degeneration","author":"Ho AC","unstructured":"Ho AC. Combination therapy with intravitreal nesvacumab and aflibercept for neovascular age-related macular degeneration. Paper Presented at:\u00a0 Angiogenesis, Exudation and Degeneration, Miami (FL), February 10, 2018."},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00459.2010"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.74.3.160"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3192"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505889"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.03.047"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.07.027"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2014.11.010"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903805106"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz5425"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.01.008"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-013-0109-z"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.8.6.1"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0393-387"},{"key":"e_1_3_5_42_1","first-page":"331","article-title":"Estimation of the intravascular half-lives of normal rhesus minkey IgG, IgA, and IgM","volume":"36","author":"Challacombe SJ","year":"1979","unstructured":"Challacombe SJ, Russell MW. Estimation of the intravascular half-lives of normal rhesus minkey IgG, IgA, and IgM. Immunology. 1979;36:331\u201338.","journal-title":"Immunology"},{"key":"e_1_3_5_43_1","first-page":"5920","article-title":"Tumor detection with 131I-labeledHuman monoclonal antibody COU-1 in patients with suspected colorectal carcinoma1","volume":"53","author":"Ditzel H","year":"1993","unstructured":"Ditzel H, Rasmussen JW, Erb K, Jensenius JC. Tumor detection with 131I-labeledHuman monoclonal antibody COU-1 in patients with suspected colorectal carcinoma1. Cancer Res. 1993;53:5920\u201328.","journal-title":"Cancer Res"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-003-0436-1"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-016-1378-0"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.20.7678"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)86976-9"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2015.11.007"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.01.011"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(97)00002-1"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2571"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.767749"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)37945-6"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10128"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.19082\/5031"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5322.55"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X15016416"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.8.4891"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402306"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410660200"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.04.017"},{"key":"e_1_3_5_62_1","first-page":"1","article-title":"Brolucizumab: evolution through preclinical and clinical studies and the implications for the management of neovascular age-related macular degeneration","author":"Nguyen QD","year":"2020","unstructured":"Nguyen QD, Das A, Do DV, Dugel P, Gomes A, Holz FG, Koh A, Pan C, Sepah YJ, Patel N, et al. Brolucizumab: evolution through preclinical and clinical studies and the implications for the management of neovascular age-related macular degeneration. Ophthalmology. 2020;127:1\u201314.","journal-title":"Ophthalmology"},{"key":"e_1_3_5_63_1","volume-title":"Extended durability in exudative retinal diseases using the novel intravitreal anti-VEGF antibody biopolymer conjugate KSI-301","author":"Do DV","unstructured":"Do DV. Extended durability in exudative retinal diseases using the novel intravitreal anti-VEGF antibody biopolymer conjugate KSI-301. Paper presented at:\u00a0 Angiogenesis, Exudation and Degeneration, Miami (FL), February 8, 2020."},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.03.036"},{"key":"e_1_3_5_65_1","volume-title":"Transcon technology for sustained delivery of proteins, peptides, and small molecules","author":"Rau H","unstructured":"Rau H, Sprogoe K. Transcon technology for sustained delivery of proteins, peptides, and small molecules. Paper presented at: Boulder Peptide Symposium, Denver (CO), September 26, 2018."},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V49.4.507.507"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.63.1.78"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00374a001"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2006.05.009"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2017.10.003"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17457"}],"container-title":["mAbs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19420862.2020.1818436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:59:32Z","timestamp":1762430372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19420862.2020.1818436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1080\/19420862.2020.1818436"],"URL":"https:\/\/doi.org\/10.1080\/19420862.2020.1818436","relation":{},"ISSN":["1942-0862","1942-0870"],"issn-type":[{"value":"1942-0862","type":"print"},{"value":"1942-0870","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kmab20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kmab20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1818436"}}