{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:39:33Z","timestamp":1792931973058,"version":"4.5.0"},"reference-count":50,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"BiVictriX Therapeutics"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["mAbs"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/19420862.2025.2551205","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T08:14:42Z","timestamp":1756714482000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["A bispecific antibody\u2013drug conjugate targeting CD7 and CD33 shows anti-tumor activity and improved tumor selectivity in an aggressive subtype of acute myeloid leukemia"],"prefix":"10.1080","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-8013","authenticated-orcid":false,"given":"Hollie B. S.","family":"Griffiths","sequence":"first","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyle","family":"Jones","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-5423","authenticated-orcid":false,"given":"Mattia","family":"Vitale","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Faulkner","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Masters","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi L. A.","family":"Nabi-Aldridge","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Mistry","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Patterson","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Blanco-Gomez","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Griessinger","sequence":"additional","affiliation":[{"name":"Independent Researcher","place":["Nice, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Schon","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7990-3563","authenticated-orcid":false,"given":"Tiffany J.","family":"Daniels-Thorn","sequence":"additional","affiliation":[{"name":"BiVictriX Therapeutics Ltd","place":["Cheshire, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25975"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0002"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2020.106339"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000577"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines4030014"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00975-2"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032718"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19446"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.22.00030"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-021-03182-y"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0180-3"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-801498"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08595.x"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.01.009"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016033"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301689"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02533-6"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0166"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa180"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb00284.x"},{"issue":"1","key":"e_1_3_6_24_1","first-page":"70","article-title":"Flow cytometric characterization of acute myeloid leukemia. Part II. Phenotypic heterogeneity at diagnosis","volume":"6","author":"Terstappen LW","year":"1992","unstructured":"Terstappen LW, Safford M, K\u00f6nemann S, Loken MR, Zurlutter K, B\u00fcchner T, Hiddemann W, W\u00f6rmann B. Flow cytometric characterization of acute myeloid leukemia. Part II. Phenotypic heterogeneity at diagnosis. Leukemia. 1992; 6(1):70\u201380.","journal-title":"Leukemia"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.3.720.720"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb06460.x"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.9.2399.2399"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.11.3083.3083"},{"issue":"10","key":"e_1_3_6_29_1","first-page":"1735","article-title":"Analysis of CD7 expression in acute myelogenous leukemia: martingale residual plots combined with \u201coptimal\u201d cutpoint analysis reveals absence of prognostic significance","volume":"9","author":"Kornblau SM","year":"1995","unstructured":"Kornblau SM, Thall P, Huh YO, Estey E, Andreeff M. Analysis of CD7 expression in acute myelogenous leukemia: martingale residual plots combined with \u201coptimal\u201d cutpoint analysis reveals absence of prognostic significance. Leukemia. 1995; 9(10):1735\u20131741.","journal-title":"Leukemia"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509051710"},{"issue":"3","key":"e_1_3_6_31_1","first-page":"239","article-title":"Biological characteristics of CD7(+) acute leukemia","volume":"21","author":"Miwa H","year":"1996","unstructured":"Miwa H, Nakase K, Kita K. Biological characteristics of CD7(+) acute leukemia. Leuk Lymphoma. 1996; 21(3\u20134):239\u2013244.","journal-title":"Leuk Lymphoma"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401067"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400893"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.3.870"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(03)00180-2"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2005.02.003"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.06.001"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.08.010"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1309\/NRTX9AKXHR5JBT93"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21539"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20598"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01819-x"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0667-1"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-22-0362"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.367"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3202"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.1.1996.5.625"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300470200"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2009.06.008"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-02127-0"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34507"}],"container-title":["mAbs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19420862.2025.2551205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:47:35Z","timestamp":1765453655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19420862.2025.2551205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/19420862.2025.2551205"],"URL":"https:\/\/doi.org\/10.1080\/19420862.2025.2551205","relation":{},"ISSN":["1942-0862","1942-0870"],"issn-type":[{"value":"1942-0862","type":"print"},{"value":"1942-0870","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kmab20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kmab20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2551205"}}