{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:52:56Z","timestamp":1776304376765,"version":"3.50.1"},"reference-count":39,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UH3 TR000504"],"award-info":[{"award-number":["UH3 TR000504"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UH3 TR000503"],"award-info":[{"award-number":["UH3 TR000503"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI089894"],"award-info":[{"award-number":["R01 AI089894"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01 AI125181"],"award-info":[{"award-number":["P01 AI125181"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI126887"],"award-info":[{"award-number":["R01 AI126887"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32 DK007632"],"award-info":[{"award-number":["T32 DK007632"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01 DK113043"],"award-info":[{"award-number":["K01 DK113043"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK089502"],"award-info":[{"award-number":["P30 DK089502"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2020,11,9]]},"DOI":"10.1080\/19490976.2020.1752125","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T13:30:45Z","timestamp":1588858245000},"page":"1752125","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":22,"title":["Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic <i>Escherichia coli<\/i> infection"],"prefix":"10.1080","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-5625","authenticated-orcid":false,"given":"Jennifer","family":"Foulke-Abel","sequence":"first","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmi","family":"Sunuwar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruxian","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-697X","authenticated-orcid":false,"given":"James M.","family":"Fleckenstein","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Kaper","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Donowitz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1186\/s40794-018-0077-1"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.8.3.322-328.1973"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01078-13"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2245-2258.2006"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1038\/nature07568"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01287.x"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31529-X"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01397-09"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01225-15"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118128"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01385.x"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.017"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1655"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314817"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3201"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.11.047"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.02.002"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.05.004"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.3791\/59357"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.10.001"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf5211"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1038\/srep45270"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97659"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00790-06"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00526-18"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1128\/JB.145.2.722-728.1981"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.20.2.352-359.1978"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.251546"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.869-875.2006"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02496-14"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005463200"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212723200"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120159197"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1038\/srep33124"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00822-08"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00928-08"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00736.x"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01749-14"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2020.1752125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T01:19:46Z","timestamp":1620609586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2020.1752125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,11,9]]}},"alternative-id":["10.1080\/19490976.2020.1752125"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2020.1752125","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}