{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:50:48Z","timestamp":1793346648840,"version":"4.5.0"},"reference-count":75,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Singapore Ministry of Health National Medical Research Council","award":["NMRC\/CIRG\/1414\/2014"],"award-info":[{"award-number":["NMRC\/CIRG\/1414\/2014"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2020,11,9]]},"DOI":"10.1080\/19490976.2020.1801964","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T01:10:36Z","timestamp":1602033036000},"page":"1801964","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":110,"title":["A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema"],"prefix":"10.1080","volume":"12","author":[{"given":"Le Duc Huy","family":"Ta","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3162-8389","authenticated-orcid":false,"given":"James Chun Yip","family":"Chan","sequence":"additional","affiliation":[{"name":"Skin Research Institute of Singapore, A*STAR, Singapore"},{"name":"Innovations in Food & Chemical Safety Programme, A*STAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaik Chin","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2790-4056","authenticated-orcid":false,"given":"Rikky W.","family":"Purbojati","sequence":"additional","affiliation":[{"name":"Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-0917","authenticated-orcid":false,"given":"Daniela I.","family":"Drautz-Moses","sequence":"additional","affiliation":[{"name":"Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing Michelle","family":"Koh","sequence":"additional","affiliation":[{"name":"Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina Jing Xuan","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung-Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorinda Yan Qin","family":"Kioh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Yun","family":"Woon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1037-6143","authenticated-orcid":false,"given":"Elizabeth Huiwen","family":"Tham","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"},{"name":"Khoo Teck Puat-National University Children\u2019s Medical Institute, National University Health System, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn Xiu Ling","family":"Loo","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette P.C.","family":"Shek","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"},{"name":"Khoo Teck Puat-National University Children\u2019s Medical Institute, National University Health System, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neerja","family":"Karnani","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo P.S.","family":"Van Bever","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"},{"name":"Khoo Teck Puat-National University Children\u2019s Medical Institute, National University Health System, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5100-1543","authenticated-orcid":false,"given":"Oon Hoe","family":"Teoh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiong Huak","family":"Chan","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Lay","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"},{"name":"Danone Nutricia Research, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Knol","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research, Utrecht, The Netherlands"},{"name":"Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Hian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yap-Seng","family":"Chong","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"},{"name":"Department of Obstetrics & Gynaecology, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Godfrey","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Kjelleberg","sequence":"additional","affiliation":[{"name":"Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan C.","family":"Schuster","sequence":"additional","affiliation":[{"name":"Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Chun Yong","family":"Chan","sequence":"additional","affiliation":[{"name":"Innovations in Food & Chemical Safety Programme, A*STAR"},{"name":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"},{"name":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bee Wah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1111\/all.12270"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.008"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2245"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13692"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00003"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4142"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1186\/1868-7083-4-4"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1134082"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1111\/all.13660"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.054"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.021"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab2271"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.06.029"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1038\/nature11053"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12487"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.040"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2018.10.4.354"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166026"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41149-6"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009964"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.100164"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.1.51"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304909"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.7.3761-3769.2005"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.12029"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032668099"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.03003-14"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01141-07"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2011.05.017"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.029017-0"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2009.06.002"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.3920\/BM2015.0056"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.97"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03391.x"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07631-x"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1021\/jf9044205"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303249"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158498"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-019-08758-5"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-015-0055-2"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0102-7"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.025"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0617-x"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.02.021"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00046-17"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00864-09"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.2741\/3603"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2746"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwt065"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.12.6757-6763.2004"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032094"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2004.tb00070.x"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-019-1489-4"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1111\/all.12549"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-95"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.045"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.047"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.02.014"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.3920\/BM2017.0020"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2012.2.2.144"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.11.040"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03234.x"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.039"},{"key":"cit0064","first-page":"225","volume":"19","author":"Khoo J","year":"2001","journal-title":"Asian Pac J Allergy Immunol"},{"key":"cit0065","first-page":"189","volume":"17","author":"Yi FC","year":"1999","journal-title":"Asian Pac J Allergy Immunol"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.01.044"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1042"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3176"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1101\/gr.120618.111"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts611"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.084"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2020.1801964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T01:31:29Z","timestamp":1620610289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2020.1801964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,6]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,11,9]]}},"alternative-id":["10.1080\/19490976.2020.1801964"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2020.1801964","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}