{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:32:37Z","timestamp":1790681557237,"version":"4.1.0"},"reference-count":71,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"name":"MSD (Merck Sharp & Dohme","award":["IIS57443"],"award-info":[{"award-number":["IIS57443"]}]},{"DOI":"10.13039\/501100000925","name":"Australian National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1107812"],"award-info":[{"award-number":["GNT1107812"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2022,12,31]]},"DOI":"10.1080\/19490976.2022.2117504","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:49:19Z","timestamp":1661996959000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":22,"title":["Bezlotoxumab prevents extraintestinal organ damage induced by\n                    <i>Clostridioides difficile<\/i>\n                    infection"],"prefix":"10.1080","volume":"14","author":[{"given":"Steven J.","family":"Mileto","sequence":"first","affiliation":[{"name":"Monash University","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie L.","family":"Hutton","sequence":"additional","affiliation":[{"name":"Monash University","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Walton","sequence":"additional","affiliation":[{"name":"Monash University","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antariksh","family":"Das","sequence":"additional","affiliation":[{"name":"Monash University","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Ioannidis","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Insitiute, Infectious Diseases and Immune Defence Division","place":["Parkville, Australia"]},{"name":"the University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Ketagoda","sequence":"additional","affiliation":[{"name":"Monash University","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie M.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Monash University","place":["Clayton, Australia"]},{"name":"RMIT University School of Biomedical and Health Sciences, Chronic Inflammatory and Infectious Diseases Program","place":["Bundoora, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate M.","family":"Denton","sequence":"additional","affiliation":[{"name":"Monash University","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana S.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Insitiute, Infectious Diseases and Immune Defence Division","place":["Parkville, Australia"]},{"name":"the University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena","family":"Lyras","sequence":"additional","affiliation":[{"name":"Monash University","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.20"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00845-15"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.26854"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.108"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000626"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00885-17"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168849"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00648-15"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166159"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.10.022"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu203"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031559"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001061"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.01.014"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2001.00313.x"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit392"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir748"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124235"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.118870"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00010"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018010068"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1199-4"},{"issue":"4","key":"e_1_3_6_24_1","first-page":"e85","article-title":"High mortality risk in chronic kidney disease and end stage kidney disease patients with Clostridium difficile infection: a systematic review and meta-analysis","volume":"1","author":"Thongprayoon C","year":"2015","unstructured":"Thongprayoon C, Cheungpasitporn W, Phatharacharukul P, Mahaparn P, Bruminhent J. High mortality risk in chronic kidney disease and end stage kidney disease patients with Clostridium difficile infection: a systematic review and meta-analysis. J Nat Sci. 2015;1(4):e85.","journal-title":"J Nat Sci"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.097"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1503.080312"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1754-7"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00551-15"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21847"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2014.06.005"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915255117"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-233"},{"key":"e_1_3_6_33_1","first-page":"117","article-title":"The de ritis ratio: the test of time","volume":"34","author":"Botros M","year":"2013","unstructured":"Botros M, Sikaris KA. The de ritis ratio: the test of time. Clin Biochem Rev. 2013;34:117\u2013130.","journal-title":"Clin Biochem Rev"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.12.011"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000052"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208937"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.03.035"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.08.026"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40793"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.02.004"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2005.03.024"},{"issue":"2","key":"e_1_3_6_42_1","first-page":"302","article-title":"Thymic epithelium in AIDS. An immunohistologic study","volume":"122","author":"Savino W","year":"1986","unstructured":"Savino W, Dardenne M, Marche C, Trophilme D, Dupuy JM, Pekovic D, Lapointe N, Bach, JF. Thymic epithelium in AIDS. An immunohistologic study. Am J Pathol. 1986;122(2):302\u2013307.","journal-title":"Am J Pathol"},{"key":"e_1_3_6_43_1","first-page":"1599","article-title":"Relationship between apoptosis and thymocyte depletion in rabies-infected mice","volume":"27","author":"Marcovistz R","year":"1994","unstructured":"Marcovistz R, Bertho AL, Matos DC. Relationship between apoptosis and thymocyte depletion in rabies-infected mice. Braz J Med Biol Res. 1994;27:1599\u20131603.","journal-title":"Braz J Med Biol Res"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.45.2.372-377.1984"},{"key":"e_1_3_6_45_1","first-page":"95","article-title":"Modulation of thymocyte subsets during acute and chronic phases of experimental Trypanosoma cruzi infection","volume":"77","author":"Leite-de-Moraes MC","year":"1992","unstructured":"Leite-de-Moraes MC, Hontebeyrie-Joskowicz M, Dardenne M, Savino W. Modulation of thymocyte subsets during acute and chronic phases of experimental Trypanosoma cruzi infection. Immunology. 1992;77:95\u201398.","journal-title":"Immunology"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.039"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602615"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2017.10.005"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis669"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2005.08.005"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12047"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1781"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1086\/649799"},{"key":"e_1_3_6_54_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.032"},{"key":"e_1_3_6_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2014.00024"},{"key":"e_1_3_6_56_1","first-page":"235","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"7","author":"Levine JS","year":"2011","unstructured":"Levine JS, Burakoff R. Extraintestinal manifestations of inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2011;7:235\u2013241.","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_3_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1511"},{"key":"e_1_3_6_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201525"},{"key":"e_1_3_6_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02897-14"},{"key":"e_1_3_6_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3567"},{"key":"e_1_3_6_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3802"},{"key":"e_1_3_6_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.11.6663"},{"key":"e_1_3_6_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001268"},{"key":"e_1_3_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.03.009"},{"key":"e_1_3_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03592-3"},{"key":"e_1_3_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2004.03.007"},{"key":"e_1_3_6_67_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0029"},{"key":"e_1_3_6_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12046"},{"key":"e_1_3_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2022.01.075"},{"key":"e_1_3_6_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13785"},{"key":"e_1_3_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.11.012"},{"key":"e_1_3_6_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910215"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2022.2117504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/19490976.2022.2117504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2022.2117504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:58:45Z","timestamp":1784185125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2022.2117504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,31]]}},"alternative-id":["10.1080\/19490976.2022.2117504"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2022.2117504","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2117504"}}