{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:29:43Z","timestamp":1792096183225,"version":"4.4.0"},"reference-count":64,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["No. 8.2.2.0\/20\/I\/006"],"award-info":[{"award-number":["No. 8.2.2.0\/20\/I\/006"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2023,12,31]]},"DOI":"10.1080\/19490976.2023.2188663","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T05:00:00Z","timestamp":1679029200000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":14,"title":["Spatial variation of the gut microbiome in response to long-term metformin treatment in high-fat diet-induced type 2 diabetes mouse model of both sexes"],"prefix":"10.1080","volume":"15","author":[{"given":"Laila","family":"Silami\u0137ele","sequence":"first","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihards","family":"Saksis","sequence":"additional","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivars","family":"Silami\u0137elis","sequence":"additional","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u012bcija Paul\u012bne","family":"Kotovi\u010da","sequence":"additional","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monta","family":"Br\u012bv\u012bba","sequence":"additional","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ineta","family":"Kalni\u0146a","sequence":"additional","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Kalni\u0146a","sequence":"additional","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u0101vids","family":"Fridmanis","sequence":"additional","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8362-5505","authenticated-orcid":false,"given":"J\u0101nis","family":"Klovi\u0146\u0161","sequence":"additional","affiliation":[{"name":"Human genetics and disease mechanisms, Latvian Biomedical Research and Study Centre, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303839"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15766"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4848-7"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.03.010"},{"key":"e_1_3_4_6_1","article-title":"Gut biogeography of the bacterial microbiota","author":"Donaldson GP","unstructured":"Donaldson GP, Lee SM, Mazmanian SK. Gut biogeography of the bacterial microbiota. Nat Rev Microbiol. 2015;14:20\u201332.","journal-title":"Nat Rev Microbiol"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01050"},{"key":"e_1_3_4_8_1","first-page":"1","article-title":"Core gut bacteria analysis of healthy mice","volume":"10","author":"Wang J","year":"2019","unstructured":"Wang J, Lang T, Shen J, Dai J, Tian L, Wang X. Core gut bacteria analysis of healthy mice. Front Microbiol. 2019;10:1\u201314.","journal-title":"Front Microbiol"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160510"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074957"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40235-z"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms6040101"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00376"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010001"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i29.8787"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802304-4.00021-9"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.019"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0488"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1053-5"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95117-0"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4345"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2017.1405209"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00170.2019"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa056"},{"key":"e_1_3_4_25_1","first-page":"1","article-title":"Metformin affects gut microbiota composition and diversity associated with amelioration of dextran sulfate sodium-induced colitis in mice","volume":"12","author":"Liu Z","year":"2021","unstructured":"Liu Z, Liao W, Zhang Z, Sun R, Luo Y, Chen Q, Li X, Lu R, Ying Y. Metformin affects gut microbiota composition and diversity associated with amelioration of dextran sulfate sodium-induced colitis in mice. Front Pharmacol. 2021;12:1\u20139.","journal-title":"Front Pharmacol"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14040329"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00939"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-021-02099-0"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-021-00702-9"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00171-16"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00299"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S286430"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.11.051"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00213"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.08.038"},{"key":"e_1_3_4_36_1","article-title":"Lactobacillus Sps in reducing the risk of diabetes in high-fat diet-induced diabetic mice by modulating the gut microbiome and inhibiting key digestive enzymes associated with diabetes","author":"Gulnaz A","year":"2021","unstructured":"Gulnaz A, Nadeem J, Han JH, Lew LC, Dong SJ, Park YH, Rather IA, Hor YY. Lactobacillus Sps in reducing the risk of diabetes in high-fat diet-induced diabetic mice by modulating the gut microbiome and inhibiting key digestive enzymes associated with diabetes. Biology (Basel). 2021;4:348.","journal-title":"Biology (Basel)"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12198"},{"key":"e_1_3_4_38_1","first-page":"10","article-title":"Metabolites produced by probiotic Lactobacilli rapidly increase glucose uptake by Caco-2 cells","author":"Rooj AK","year":"2010","unstructured":"Rooj AK, Kimura Y, Buddington RK. Metabolites produced by probiotic Lactobacilli rapidly increase glucose uptake by Caco-2 cells. BMC Microbiol. 2010;16:10.","journal-title":"BMC Microbiol"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800870"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2020.107795"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2021.100912"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.190009"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2016.07.002"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122862"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01530-14"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.10.6321-6326.2003"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.626359"},{"key":"e_1_3_4_48_1","volume-title":"The design of animal experiments: reducing the use of animals in research through better experimental design (Laboratory Animal Handbooks)","author":"Festing MFW","year":"2016","unstructured":"Festing MFW, Overend P, Cortina Borja M, Berdoy M. The design of animal experiments: reducing the use of animals in research through better experimental design (Laboratory Animal Handbooks). Second ed. London, United Kingdom: SAGE Publications Ltd; 2016."},{"key":"e_1_3_4_49_1","unstructured":"Andrews S. FastQC: a quality control tool for high throughput sequence data [Online]. 2010; Available from: http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009581"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0470-z"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.03.23.436606"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0396-x"},{"key":"e_1_3_4_59_1","first-page":"247","article-title":"SEPP: sAT\u00e9-enabled phylogenetic placement","author":"Mirarab S","year":"2012","unstructured":"Mirarab S, Nguyen NW. SEPP: sAT\u00e9-enabled phylogenetic placement. Pac Symp Biocomput. 2012;1:247\u2013258.","journal-title":"Pac Symp Biocomput"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.03201"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1109\/MCSE.2007.55"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17041-7"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.25080\/Majora-92bf1922-00a"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2023.2188663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T22:46:55Z","timestamp":1711666015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2023.2188663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,31]]}},"alternative-id":["10.1080\/19490976.2023.2188663"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2023.2188663","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2188663"}}