{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:52:56Z","timestamp":1792691576674,"version":"4.5.0"},"reference-count":61,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L001489\/1"],"award-info":[{"award-number":["MR\/L001489\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2023,12,31]]},"DOI":"10.1080\/19490976.2023.2208501","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T12:24:13Z","timestamp":1684239853000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":32,"title":["Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-9672","authenticated-orcid":false,"given":"Laura","family":"Martinez-Gili","sequence":"first","affiliation":[{"name":"Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"},{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-2461","authenticated-orcid":false,"given":"Alexandros","family":"Pechlivanis","sequence":"additional","affiliation":[{"name":"Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"},{"name":"Biomic_Auth, Bioanalysis and Omics Laboratory, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Centre, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-6047","authenticated-orcid":false,"given":"Julie A.K.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7689-0087","authenticated-orcid":false,"given":"Sofina","family":"Begum","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Badrock","sequence":"additional","affiliation":[{"name":"Academic Department of Medical Genetics, Cambridge University, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-5225","authenticated-orcid":false,"given":"Jessica K.","family":"Dyson","sequence":"additional","affiliation":[{"name":"Liver Unit, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"},{"name":"Institute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Jones","sequence":"additional","affiliation":[{"name":"Leeds Liver Unit, St James\u2019s University Hospital, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-2255","authenticated-orcid":false,"given":"Gideon","family":"Hirschfield","sequence":"additional","affiliation":[{"name":"Center for Liver and Gastroenterology Research and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-4444","authenticated-orcid":false,"given":"Stephen D.","family":"Ryder","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre at Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sandford","sequence":"additional","affiliation":[{"name":"Academic Department of Medical Genetics, Cambridge University, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Rushbrook","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Thorburn","sequence":"additional","affiliation":[{"name":"UCL Royal Free Campus, Royal Free Hospital, University College London Institute of Liver and Digestive Health, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8811-1834","authenticated-orcid":false,"given":"Simon D.","family":"Taylor-Robinson","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.E.","family":"Crossey","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-5239","authenticated-orcid":false,"given":"Julian R.","family":"Marchesi","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mells","sequence":"additional","affiliation":[{"name":"Academic Department of Medical Genetics, Cambridge University, Cambridge, UK"},{"name":"Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-8389","authenticated-orcid":false,"given":"Elaine","family":"Holmes","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK"},{"name":"Center for Computational &amp; Systems Medicine, Murdoch University, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jones","sequence":"additional","affiliation":[{"name":"Liver Unit, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"},{"name":"Institute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315259"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318261e659"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0249-x"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1055953"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2018.06.006"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000557"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.029"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0051-9"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.216"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.119"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1810531"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311004"},{"key":"e_1_3_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99314-9"},{"key":"e_1_3_7_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.984697"},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313332"},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.12.005"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.789"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32011"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.07.002"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17041-7"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2881-9"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6286"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2210-7401(12)70015-3"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b21-00332"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01312-x"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnab038"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.06.002"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022094"},{"key":"e_1_3_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91610-2"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02779195"},{"key":"e_1_3_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01315142"},{"key":"e_1_3_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290220"},{"key":"e_1_3_7_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02475-17"},{"key":"e_1_3_7_35_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R500013-JLR200"},{"key":"e_1_3_7_36_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2700691"},{"key":"e_1_3_7_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b20-00021"},{"key":"e_1_3_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2018.06.007"},{"key":"e_1_3_7_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1946366"},{"key":"e_1_3_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.572912"},{"key":"e_1_3_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110649"},{"key":"e_1_3_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25599"},{"key":"e_1_3_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2047-9"},{"key":"e_1_3_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-019-08731-2"},{"key":"e_1_3_7_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b01556"},{"key":"e_1_3_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2377"},{"key":"e_1_3_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab433"},{"key":"e_1_3_7_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5025039"},{"key":"e_1_3_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac051632c"},{"key":"e_1_3_7_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac048630x"},{"key":"e_1_3_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2018.04.028"},{"key":"e_1_3_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_3_7_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227434"},{"key":"e_1_3_7_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0521-5"},{"key":"e_1_3_7_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0605-2"},{"key":"e_1_3_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2015.02.019"},{"key":"e_1_3_7_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/1471082X14535524"},{"key":"e_1_3_7_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00354"},{"key":"e_1_3_7_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02224"},{"key":"e_1_3_7_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02114"},{"key":"e_1_3_7_61_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_3_7_62_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2023.2208501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T22:48:15Z","timestamp":1711666095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2023.2208501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,31]]}},"alternative-id":["10.1080\/19490976.2023.2208501"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2023.2208501","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2208501"}}