{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:04:52Z","timestamp":1793228692747,"version":"4.5.0"},"reference-count":70,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/19490976.2025.2562341","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:35:32Z","timestamp":1759728932000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Proton pump inhibitors are not associated with an increased risk of\n                    <i>Clostridioides difficile<\/i>\n                    infection: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1080","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-9913","authenticated-orcid":false,"given":"Diana-Elena","family":"Floria","sequence":"first","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Grigore T. Popa University of Medicine and Pharmacy","place":["Ia\u0219i, Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-2573","authenticated-orcid":false,"given":"Mahmoud","family":"Obeidat","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-8163","authenticated-orcid":false,"given":"Szil\u00e1rd","family":"V\u00e1ncsa","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Institute of Pancreatic Diseases, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarolta Be\u00e1ta","family":"K\u00e1v\u00e1si","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Department of Surgery, Toldy Ferenc Hospital","place":["Cegl\u00e9d, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-721X","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"F\u00f6ldv\u00e1ri-Nagy","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-7259","authenticated-orcid":false,"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Institute of Pancreatic Diseases, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs","place":["P\u00e9cs, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9687-3556","authenticated-orcid":false,"given":"D\u00e1niel S\u00e1ndor","family":"Veres","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Department of Biophysics and Radiation Biology, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-2656","authenticated-orcid":false,"given":"Vasile-Liviu","family":"Drug","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Grigore T. Popa University of Medicine and Pharmacy","place":["Ia\u0219i, Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3658-8427","authenticated-orcid":false,"given":"B\u00e1lint","family":"Er\u0151ss","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Institute of Pancreatic Diseases, Semmelweis University","place":["Budapest, Hungary"]},{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs","place":["P\u00e9cs, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,10,5]]},"reference":[{"key":"e_1_3_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-13217-6"},{"key":"e_1_3_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.247"},{"key":"e_1_3_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-023-03534-z"},{"key":"e_1_3_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056060"},{"key":"e_1_3_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-023-00489-x"},{"key":"e_1_3_8_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i35.6500"},{"key":"e_1_3_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.08.017"},{"key":"e_1_3_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.01.008"},{"key":"e_1_3_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa545"},{"key":"e_1_3_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2013.12.003"},{"key":"e_1_3_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08096-0"},{"key":"e_1_3_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1085"},{"key":"e_1_3_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848211016248"},{"key":"e_1_3_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1371-9"},{"key":"e_1_3_8_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000501"},{"key":"e_1_3_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17071251"},{"key":"e_1_3_8_18_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001538"},{"key":"e_1_3_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.05.056"},{"key":"e_1_3_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2404245"},{"key":"e_1_3_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_8_22_1","volume-title":"Cochrane handbook for systematic reviews of interventions version 6.3","author":"Higgins J","year":"2022","unstructured":"Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, et al. Cochrane handbook for systematic reviews of interventions version 6.3. 2022. (updated February 2022). London, UK: Cochrane."},{"key":"e_1_3_8_23_1","volume-title":"Proton pump inhibitors are not associated with an increased risk of Clostridioides difficile infection: a systematic review and meta-analysis of randomized controlled trials [Internet]","author":"Floria D-E","unstructured":"Floria D-E, Obeidat M, V\u00e1ncsa S, K\u00e1v\u00e1si SB, F\u00f6ldv\u00e1ri-Nagy L, Hegyi P, Veres DS, Drug VL, Eross B. Proton pump inhibitors are not associated with an increased risk of Clostridioides difficile infection: a systematic review and meta-analysis of randomized controlled trials [Internet]. New York, USA: SSRN."},{"key":"e_1_3_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_3_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_3_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_3_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_3_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0900900202"},{"key":"e_1_3_8_29_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003107347"},{"key":"e_1_3_8_30_1","volume-title":"R: a language and environment for statistical computing","author":"Team RC","year":"2023","unstructured":"Team RC. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2023."},{"key":"e_1_3_8_31_1","volume-title":"Meta: general package for meta-analysis","author":"Schwarzer G","year":"2022","unstructured":"Schwarzer G. Meta: general package for meta-analysis. 2022. Vienna, Austria: The R Foundation for Statistical Computing."},{"key":"e_1_3_8_32_1","volume-title":"Dmetar: companion R package for the guide doing meta-analysis in R","author":"Pim C","year":"2022","unstructured":"Pim C, Furukawa T, Ebert DD. Dmetar: companion R package for the guide doing meta-analysis in R. 2022. Vienna, Austria: The R Foundation for Statistical Computing."},{"key":"e_1_3_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002461"},{"key":"e_1_3_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.08.036"},{"key":"e_1_3_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714919"},{"key":"e_1_3_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001819"},{"key":"e_1_3_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22190"},{"issue":"12","key":"e_1_3_8_38_1","article-title":"IV famotidine vs. IV pantoprazole for stress ulcer prevention in the ICU: a prospective study","volume":"41","author":"Wee B","year":"2013","unstructured":"Wee B, Liu C, Cohen H, Kravchuk S, Reddy K. IV famotidine vs. IV pantoprazole for stress ulcer prevention in the ICU: a prospective study. Crit Care Med [Internet]. 2013;41(12 Suppl 1):A181. Available from: http:\/\/ovidsp.ovid.com\/ovidweb.cgi?T=JS&PAGE=reference&D=emed11&NEWS=N&AN=71533909.","journal-title":"Crit Care Med [Internet]"},{"key":"e_1_3_8_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007964"},{"key":"e_1_3_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(22)62400-4"},{"key":"e_1_3_8_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314852"},{"key":"e_1_3_8_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.09.041"},{"key":"e_1_3_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13331"},{"key":"e_1_3_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.08.004"},{"key":"e_1_3_8_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318715"},{"key":"e_1_3_8_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.54"},{"key":"e_1_3_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77245-1"},{"key":"e_1_3_8_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.006"},{"key":"e_1_3_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92962-2"},{"key":"e_1_3_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.033"},{"key":"e_1_3_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0576-5"},{"key":"e_1_3_8_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017788"},{"key":"e_1_3_8_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1057800"},{"key":"e_1_3_8_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2023.2204229"},{"key":"e_1_3_8_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00768.x"},{"key":"e_1_3_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90363-0"},{"key":"e_1_3_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.03.001"},{"key":"e_1_3_8_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31826af61a"},{"key":"e_1_3_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2014.11.003"},{"key":"e_1_3_8_60_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.194"},{"key":"e_1_3_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.108"},{"key":"e_1_3_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.09.030"},{"key":"e_1_3_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.179"},{"key":"e_1_3_8_64_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16568"},{"key":"e_1_3_8_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1369-3"},{"key":"e_1_3_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01275.x"},{"key":"e_1_3_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.46"},{"key":"e_1_3_8_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12304"},{"key":"e_1_3_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)37311-1"},{"key":"e_1_3_8_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051532"},{"key":"e_1_3_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01458-8"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2025.2562341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T02:48:50Z","timestamp":1766112530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2025.2562341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,5]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/19490976.2025.2562341"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2025.2562341","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2562341"}}