{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T07:58:40Z","timestamp":1794297520507,"version":"4.9.0"},"reference-count":46,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["No. 2023A1515012418"],"award-info":[{"award-number":["No. 2023A1515012418"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/19490976.2025.2610077","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T05:56:36Z","timestamp":1767419796000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Tamoxifen induced hepatotoxicity via gut microbiota-mediated hyodeoxycholic acid depletion and Farnesoid X receptor signaling disruption"],"prefix":"10.1080","volume":"18","author":[{"given":"Yuchun","family":"Chen","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]},{"name":"Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control","place":["Shenzhen, China"]},{"name":"Department of Pharmacology and Pharmacy, The University of Hong Kong","place":["Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Qin","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifang","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibao","family":"Jin","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshi","family":"Mo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houshuang","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3059-8130","authenticated-orcid":false,"given":"Yanjun","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.2000"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)32381-3"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-18-3634"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08538-5"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14434"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-018-0171-y"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320204"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0269-9"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25979"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33299-5"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.003"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00690-y"},{"key":"e_1_3_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00904-3"},{"key":"e_1_3_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.017"},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.09.032"},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2390176"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000001052"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar7201"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.10.008"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf8403"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34671-1"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01528-8"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00156"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.07.011"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.08.008"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.06.012"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1918095117"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191175"},{"key":"e_1_3_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0222-4"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12896-x"},{"key":"e_1_3_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.12.001"},{"key":"e_1_3_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.04.018"},{"key":"e_1_3_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1539"},{"key":"e_1_3_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26506-1"},{"key":"e_1_3_7_36_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201903244R"},{"key":"e_1_3_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00805-x"},{"key":"e_1_3_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30975"},{"key":"e_1_3_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.119"},{"key":"e_1_3_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41061-8"},{"key":"e_1_3_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.10.028"},{"key":"e_1_3_7_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2410475"},{"key":"e_1_3_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.10.007"},{"key":"e_1_3_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2024.05.003"},{"key":"e_1_3_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118172"},{"key":"e_1_3_7_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2181930"},{"key":"e_1_3_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.017"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2025.2610077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T05:56:39Z","timestamp":1767419799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2025.2610077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/19490976.2025.2610077"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2025.2610077","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2610077"}}