{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:01:28Z","timestamp":1792119688952,"version":"4.4.0"},"reference-count":60,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Excellent Youth Science Foundation of Henan Province","award":["232300421048"],"award-info":[{"award-number":["232300421048"]}]},{"name":"General Program of China Postdoctoral Science Foundation","award":["2023M733233"],"award-info":[{"award-number":["2023M733233"]}]},{"name":"Medical Science and Technology Tackling Plan Provincial and Ministerial Major Projects of Henan Province","award":["SBGJ202101015"],"award-info":[{"award-number":["SBGJ202101015"]}]},{"name":"Scientific Research and Innovation Excellence Team of First Affiliated Hospital of Zhengzhou University","award":["ZYCXTD2023006"],"award-info":[{"award-number":["ZYCXTD2023006"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U25A20101"],"award-info":[{"award-number":["U25A20101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172129"],"award-info":[{"award-number":["82172129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82202370"],"award-info":[{"award-number":["82202370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/19490976.2026.2630475","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T04:41:42Z","timestamp":1771735302000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Aging-caused the changes of the gut microbiota drive intestinal barrier dysfunction and increase sepsis susceptibility"],"prefix":"10.1080","volume":"18","author":[{"given":"Huoyan","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Key Laboratory of Critical Care Medicine, Henan International Joint Laboratory of Infection and Immunology, Henan Province Engineering Technology Research Center of Precision Medicine for Organ Dysfunction, The First Affiliated Hospital","place":["Zhengzhou, People's Republic of China"]},{"name":"Zhengzhou University","place":["Zhengzhou, People's Republic of China"]},{"name":"Institute of Infection and Immunity, Henan Academy of Innovations in Medical Science","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Department of Emergency Medicine","place":["Zhengzhou, People's Republic of China"]},{"name":"The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center","place":["Zhengzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0752-4"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(19)32989-7"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000004155"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-023-01233-7"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04385-x"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000003085"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000003458"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.044"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-023-00340-6"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04835-8"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00052-23"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.077"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1865-0"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.015"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1061444"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2045876"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7419"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.026"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100859"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111454"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-02981-0"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.015"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147056"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.69.5.2568-2579.2003"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.048"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04698-22"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00597-z"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01385"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01960"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1528-y"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000194535.82812.ba"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000261890.41311.e9"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201301-0036CP"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0000000000000182"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501049112"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322599"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.004"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.024"},{"key":"e_1_3_5_40_1","first-page":"1033","article-title":"Jr., preservation of myocardial ultrastructure after 24 hours of klebsiella sepsis: histologic, functional, and biochemical correlations","volume":"81","author":"Hoover EL","year":"1989","unstructured":"Hoover EL, Roberts AJ, Harrison B, Williams W, Weaver WL, Alonso DR, Subramanian VA, Gay WA. Jr., preservation of myocardial ultrastructure after 24 hours of klebsiella sepsis: histologic, functional, and biochemical correlations. J Nat Med Assoc. 1989;81:1033\u20131040. published online EpubOct.","journal-title":"J Nat Med Assoc"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2024.02.008"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11111629"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12774"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.03.017"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.68.7.3462-3466.2002"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2021.109459"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01130"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10020070"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199610000-00012"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2018.1027"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-016-0109-y"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.4.1978"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s417627"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009485107"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5380319"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2022-22036"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17465"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0723-6"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.00880-18"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1738"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1970.01340280030009"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2026.2630475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:18:40Z","timestamp":1772709520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2026.2630475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/19490976.2026.2630475"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2026.2630475","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2630475"}}