{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:42:04Z","timestamp":1794336124027,"version":"4.9.0"},"reference-count":64,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"name":"FRQS Clinician Scientist Award"},{"name":"Terry Fox Clinician-Scientist"},{"name":"Terry Fox Young Investigator Award"},{"DOI":"10.13039\/100015545","name":"Seerave Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Gut Microbes"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/19490976.2026.2699457","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:31:17Z","timestamp":1784118677000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Dietary intervention through bacterial-derived butyrate elicits anti-tumor activity and increases anti-PD-1 response"],"prefix":"10.1080","volume":"18","author":[{"given":"Myriam","family":"Benla\u00effaoui","sequence":"first","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]},{"name":"D\u00e9partement de Microbiologie, infectiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corentin","family":"Richard","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Hunter","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder Orlando","family":"M\u00e9ndez-Salazar","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylva","family":"Kourtian","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Malo","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogjena Katerina","family":"Prifti","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Ponce","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumia","family":"Khalfi","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiam","family":"Belka\u00efd","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Messaoudene","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Boidot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Unit\u00e9 de Biologie Mol\u00e9culaire, ICMUB UMR CNRS 6302","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Truntzer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Cancer Biology Transfer Platform, INSERM, CTM UMR 1231, TIRECs Team","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Girhinghelli","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Cancer Biology Transfer Platform, INSERM, CTM UMR 1231, TIRECs Team","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lehoux-Duboix","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Nutrition, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronela","family":"Ancuta","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]},{"name":"D\u00e9partement de Microbiologie, infectiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Elkrief","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]},{"name":"Oncology Division, Department of Medicine, University of Montreal Hospital Centre (CHUM)","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Marcil","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Nutrition, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al","place":["Montreal, Canada"]},{"name":"Centre de Recherche Azrieli du CHU Sainte-Justine","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Routy","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de Montr\u00e9al (CRCHUM)","place":["Montr\u00e9al, Canada"]},{"name":"Oncology Division, Department of Medicine, University of Montreal Hospital Centre (CHUM)","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2502931"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030320"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101478"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01655-5"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01698-2"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb5920"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02453-x"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0808"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01694-6"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179588"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00115-21"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2024.01.028"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10122507"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1104224"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.01.035"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz7015"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01965-2"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.7753"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac175"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.12.007"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24331-1"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.002"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1577906"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16079-x"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00687"},{"key":"e_1_3_5_27_1","article-title":"Metagenomics and culturomics reveal the dual role of gut microbiome in the development of immune-related toxicities and immune checkpoint inhibitors efficacy in cancer [Internet]","author":"Diop K","year":"2025","unstructured":"Diop K , Benla\u00effaoui M , Hunter S , M\u00e9ndez-Salazar EO , Hakozaki T , Richard C , Prifti DK , Kourtian S , Proulx-Rocray F , Naimi S , Ponce M , Messaoudene M , Cauchois F , Belkaid W , Bataille V , Lee K , Mihalcioiu C , Ian RW , Elkrief A , Routy B . Metagenomics and culturomics reveal the dual role of gut microbiome in the development of immune-related toxicities and immune checkpoint inhibitors efficacy in cancer [Internet]. Review. 2025. [cited 2026 Jan 7]. Available from: https:\/\/www.researchsquare.com\/article\/rs-7520834\/v1.","journal-title":"Review"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2014.11.015"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-0600"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-55387-w"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_5_32_1","doi-asserted-by":"crossref","DOI":"10.1101\/060012","article-title":"Fast gene set enrichment analysis [Internet]","author":"Korotkevich G","year":"2016","unstructured":"Korotkevich G , Sukhov V , Budin N , Shpak B , Artyomov MN , Sergushichev A . Fast gene set enrichment analysis [Internet]. Bioinformatics. 2016. Available from: http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/060012.","journal-title":"Bioinformatics"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902880"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980016001099"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-018-0355-9"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1163\/18762891-20220113"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz862"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2105637"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37019-2"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112634"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.02.040"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-024-00630-w"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.70335"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02203-z"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2023.101092"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.44912"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12990"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208344"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12820"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2014.07.028"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels11100829"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2019.00047"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15061510"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072402"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06586-0"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2016.176"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330291"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2249143"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76109-y"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030996"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1022688"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.010"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0125-8"}],"container-title":["Gut Microbes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2026.2699457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/19490976.2026.2699457","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19490976.2026.2699457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:31:19Z","timestamp":1784118679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2026.2699457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/19490976.2026.2699457"],"URL":"https:\/\/doi.org\/10.1080\/19490976.2026.2699457","relation":{},"ISSN":["1949-0976","1949-0984"],"issn-type":[{"value":"1949-0976","type":"print"},{"value":"1949-0984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kgmi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2699457"}}