{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:58:57Z","timestamp":1792785537388,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902081"],"award-info":[{"award-number":["81902081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572014"],"award-info":[{"award-number":["81572014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871682"],"award-info":[{"award-number":["81871682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M640858"],"award-info":[{"award-number":["2018M640858"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019T120771"],"award-info":[{"award-number":["2019T120771"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["19ykpy170"],"award-info":[{"award-number":["19ykpy170"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["17ykpy09"],"award-info":[{"award-number":["17ykpy09"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902081"],"award-info":[{"award-number":["81902081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572014"],"award-info":[{"award-number":["81572014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["and 81871682"],"award-info":[{"award-number":["and 81871682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M640858"],"award-info":[{"award-number":["2018M640858"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019T120771"],"award-info":[{"award-number":["2019T120771"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pearl River Nova Program of Guangzhou","award":["No.201710010030"],"award-info":[{"award-number":["No.201710010030"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["19ykpy170 and 17ykpy09"],"award-info":[{"award-number":["19ykpy170 and 17ykpy09"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science and Technology Major Project","award":["2018ZX10101002-001"],"award-info":[{"award-number":["2018ZX10101002-001"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Schistosomiasis is characterized by liver fibrosis, and studies have indicated that\n                    <jats:italic>Schistosoma japonicum<\/jats:italic>\n                    (\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    ) eggs can limit the progression of liver fibrosis. However, the detailed molecular mechanisms are yet unclear. Extracellular vesicles (EVs) contain a selection of miRNAs for long\u2010distance exchange of information and act as an important pathway for host\u2010parasite communication. This study aimed to explore the potential role of\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    egg\u2010derived EVs and its key miRNA in liver fibrosis. Herein, we found that\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    egg\u2010derived EVs can inhibit the activation of hepatic stellate cells, which is mediated via the high expression of Sja\u2010miR\u201071a. Sja\u2010miR\u201071a in EVs attenuates the pathological progression and liver fibrosis in\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    infection. Sja\u2010miR\u201071a inhibiting TGF\u2010\u03b21\/SMAD and interleukin (IL)\u201013\/STAT6 pathways via directly targeting semaphorin 4D (Sema4D). In addition, Sja\u2010miR\u201071a can also suppress liver fibrosis by regulating Th1\/Th2\/Th17 and Treg balance. This study contributes to further understanding of the molecular mechanisms underlying\n                    <jats:italic>Schistosoma<\/jats:italic>\n                    \u2010host interactions, and Sema4D may be a potential target for schistosomiasis liver fibrosis treatment.\n                  <\/jats:p>","DOI":"10.1080\/20013078.2020.1785738","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T07:43:02Z","timestamp":1594280582000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":71,"title":["Sja\u2010miR\u201071a in\n                    <i>Schistosome<\/i>\n                    egg\u2010derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D"],"prefix":"10.1002","volume":"9","author":[{"given":"Lifu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Parasitology of Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education Sun Yat\u2010sen University Guangzhou China"},{"name":"Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Parasitology of Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education Sun Yat\u2010sen University Guangzhou China"},{"name":"Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibing","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical Department of Xizang Minzu University Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Second Provincial General Hospital Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Parasitology of Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education Sun Yat\u2010sen University Guangzhou China"},{"name":"Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Parasitology of Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education Sun Yat\u2010sen University Guangzhou China"},{"name":"Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Wu","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Parasitology of Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education Sun Yat\u2010sen University Guangzhou China"},{"name":"Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Parasitology of Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education Sun Yat\u2010sen University Guangzhou China"},{"name":"Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Xu","sequence":"additional","affiliation":[{"name":"Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongdao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Parasitology of Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education Sun Yat\u2010sen University Guangzhou China"},{"name":"Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Parasitology of Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education Sun Yat\u2010sen University Guangzhou China"},{"name":"Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708578114"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068479"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.12.009"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005268"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep30957"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003106"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1698889"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.014"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.02.012"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00850"},{"key":"e_1_2_9_12_2","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.3389\/fmicb.2019.02707","article-title":"miRNA\u2010seq of Echinococcus multilocularis extracellular vesicles and immunomodulatory effects of miR\u20104989","volume":"10","author":"Ding J","year":"2019","journal-title":"Front Microbiol"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1578116"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6488"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4373-7"},{"key":"e_1_2_9_16_2","first-page":"378","article-title":"Schistosomal MicroRNAs isolated from extracellular vesicles in sera of infected patients: a new tool for diagnosis and follow\u2010up of human schistosomiasis","volume":"215","author":"Meningher T","year":"2016","journal-title":"J Infect Dis"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep25885"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.28665"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21587-4"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007817"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1845-2"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201947882"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0250-9"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1698795"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2017.1401897"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1643670"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27671"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2017.05.007"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.01.007"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-016-0983-5"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24277"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.05.228"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.018"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i9.1405"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3545"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1731"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1086\/510313"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039307"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12029"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2013.11.003"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.05.004"},{"key":"e_1_2_9_43_2","article-title":"A schistosome miRNA promotes host hepatic fibrosis by targeting transforming growth factor beta receptor III","author":"He X","journal-title":"J Hepatol"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41800-2"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep23550"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.06.010"},{"key":"e_1_2_9_47_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-21587-4","article-title":"Vesicle\u2010based secretion in schistosomes: analysis of protein and microRNA (miRNA) content of exosome\u2010like vesicles derived from Schistosoma mansoni","volume":"8","author":"Samoil V","year":"2018","journal-title":"Sci Rep"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2015.06.002"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.23716"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.08.026"},{"key":"e_1_2_9_51_2","doi-asserted-by":"crossref","DOI":"10.1126\/science.1071809","article-title":"Signal transduction by the TGF\u2010\u03b2 superfamily","volume":"296","author":"Attisano L","year":"2002","journal-title":"Science"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62324-3"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415627681"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040104"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007609"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.026"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00176.x"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12105"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1332"}],"container-title":["Journal of Extracellular Vesicles"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/20013078.2020.1785738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1080\/20013078.2020.1785738","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/20013078.2020.1785738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:30:39Z","timestamp":1781692239000},"score":1,"resource":{"primary":{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1080\/20013078.2020.1785738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,9]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1080\/20013078.2020.1785738"],"URL":"https:\/\/doi.org\/10.1080\/20013078.2020.1785738","archive":["Portico"],"relation":{},"ISSN":["2001-3078","2001-3078"],"issn-type":[{"value":"2001-3078","type":"print"},{"value":"2001-3078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=zjev20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=zjev20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1785738"}}