{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:03:33Z","timestamp":1792821813659,"version":"4.5.0"},"reference-count":100,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Virulence"],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1080\/21505594.2019.1656503","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T05:43:14Z","timestamp":1566884594000},"page":"768-775","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":36,"title":["Host and viral mechanisms of congenital Zika syndrome"],"prefix":"10.1080","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8823-2804","authenticated-orcid":false,"given":"Brooke","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Paulo","family":"Guida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira U.","family":"Mysorekar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"CIT0001","unstructured":"Monitoramento dos casos de microcefalias no Brasil. 2015; Brasil Minist\u00e9rio da Sa\u00fade. Available from: http:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2015\/dezembro\/30\/COES-Microcefalias\u2014-Informe-Epidemiol\u2013gico\u2014SE-51\u201429dez2015\u201415h.pdf"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.16.178608"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.3201\/eid2110.150847"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2018.02.008"},{"key":"CIT0007","unstructured":"Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations. 2016; World Health Organization. Available from:https:\/\/www.who.int\/en\/news-room\/detail\/01-02-2016-who-statement-on-the-first-meeting-of-the-international-health-regulations-(2005)-(ihr-2005)-emergency-committee-on-zika-virus-and-observed-increase-in-neurological-disorders-and-neonatal-malformations"},{"key":"CIT0008","unstructured":"Consensus on causal link between Zika and neurological disorders. 2016; World Health Organization. Available from: http:\/\/www.euro.who.int\/en\/health-topics\/emergencies\/zika-virus\/news\/news\/2016\/04\/consensus-on-causal-link-between-zika-and-neurological-disorders"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000440"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090442"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805715"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.03.001"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12847"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.07.002"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.015"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88461"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12613"},{"key":"CIT0018","first-page":"S66","volume":"37","author":"Zorrilla CD","year":"2018","journal-title":"P R Health Sci J"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-017-0285-6"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.3720"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61273-9"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00096-7"},{"key":"CIT0023","author":"Diamond MS","year":"2018","journal-title":"Annu Rev Med"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.021"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0039-7"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.04.024"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.04.007"},{"key":"CIT0028","volume-title":"Handbook of placental pathology","author":"Faye-Petersen OM","year":"2006","edition":"2"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg043"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00001.2005"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.010"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.009"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642627"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.008"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aao1680"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar3446"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.008"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.059"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.058"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07993-2"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.004"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix204"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14575"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006994"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.04.003"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.01.003"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.09.025"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86654"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304718110"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123940"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170957"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00402"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0213"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2017.09.006"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006926"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.58"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1038\/nature18296"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.03.002"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1242\/dev.140707"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6116"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.04.014"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-006-0903-z"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.11.009"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4184"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.07.004"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.068"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.11.023"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.02.002"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.07.019"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b01002"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15467-6"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-7-9"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1002\/art.11304"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211208"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.181046"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002203"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0397-SA"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00009-17"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2017.03.006"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0382-RA"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1985"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2017.0011"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmw080"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1580089"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1605445"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160085"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30883-2"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6506e1"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.01.020"},{"key":"CIT0090","unstructured":"Health BMo. PROTOCOLO DE VIGIL\u00c2NCIA E RESPOSTA \u00c0 OCORR\u00caNCIA DE MICROCEFALIA E\/OU ALTERA\u00c7\u00d5ES DO SISTEMA NERVOSO CENTRAL (SNC) Available from:http:\/\/combateaedes.saude.gov.br\/images\/sala-de-situacao\/Microcefalia-Protocolo-de-vigilancia-e-resposta-10mar2016-18h.pdf2016"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1605898"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0401-OA"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1610614"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30102-0"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.3201\/eid2306.161702"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30902-3"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0179-2015"},{"key":"CIT0098","unstructured":"Fact sheet: abortion in Latin America and the Caribbean 2015; Guttmacher Institute. Available from: https:\/\/www.guttmacher.org\/pubs\/IB_AWW-Latin-America.pdf"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(17)30021-4"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0233-4"}],"container-title":["Virulence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21505594.2019.1656503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T21:07:04Z","timestamp":1599426424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21505594.2019.1656503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":100,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"alternative-id":["10.1080\/21505594.2019.1656503"],"URL":"https:\/\/doi.org\/10.1080\/21505594.2019.1656503","relation":{},"ISSN":["2150-5594","2150-5608"],"issn-type":[{"value":"2150-5594","type":"print"},{"value":"2150-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kvir20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kvir20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}