{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:41:54Z","timestamp":1770982914088,"version":"3.50.1"},"reference-count":39,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Adipocyte"],"published-print":{"date-parts":[[2022,12,31]]},"DOI":"10.1080\/21623945.2022.2089394","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T07:30:10Z","timestamp":1655969410000},"page":"366-378","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity"],"prefix":"10.1080","volume":"11","author":[{"given":"Helen","family":"Imrie","sequence":"first","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hema","family":"Viswambharan","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie J","family":"Haywood","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine I","family":"Bridge","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadira Y","family":"Yuldasheva","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey","family":"Galloway","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie J","family":"Simmons","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M","family":"Cubbon","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piruthivi","family":"Sukumar","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole T","family":"Watt","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laeticia","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy I","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-4519","authenticated-orcid":false,"given":"Robert","family":"Goldin","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Rode","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B","family":"Wheatcroft","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark T","family":"Kearney","sequence":"additional","affiliation":[{"name":"Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00240-9"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10842"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.09.025"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.06.013"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.06.019"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415475111"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70596-5"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.2174\/138945011798829401"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28941"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800240-JLR200"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77812"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810780"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73468"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71643"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25450"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030064"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1538"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1905"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.008"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0197"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700651200"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1712"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313201200"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2146"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150041"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2018.1549974"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-4-59"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00015-8"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0436"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3122"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202050767"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12646"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-011-0266-4"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00136.2016"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914076107"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1641"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.4.1082"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04193.x"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0062"}],"container-title":["Adipocyte"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21623945.2022.2089394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T07:22:59Z","timestamp":1671434579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21623945.2022.2089394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,31]]}},"alternative-id":["10.1080\/21623945.2022.2089394"],"URL":"https:\/\/doi.org\/10.1080\/21623945.2022.2089394","relation":{},"ISSN":["2162-3945","2162-397X"],"issn-type":[{"value":"2162-3945","type":"print"},{"value":"2162-397X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kadi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kadi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}