{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:05:53Z","timestamp":1781114753007,"version":"3.54.1"},"reference-count":56,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-5-075"],"award-info":[{"award-number":["2021-I2M-5-075"]}]},{"name":"the National Major Scientifc and Technological Special Project for Signifcant New Drugs Development","award":["2018ZX09201018, 2017ZX09302010"],"award-info":[{"award-number":["2018ZX09201018, 2017ZX09302010"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["OncoImmunology"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/2162402x.2026.2684136","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:16:52Z","timestamp":1781111812000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["FTL008.16, a 5T4-Conditional 4-1BB bispecific antibody, potently enhances antitumor immunity via tumor-directed t-cell activation"],"prefix":"10.1080","volume":"15","author":[{"given":"Shuang","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyan","family":"Tu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Sound Biopharmaceuticals Co., Ltd., Tianfu International Bio-Town","place":["Chengdu, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qu","sequence":"additional","affiliation":[{"name":"Sound Biopharmaceuticals Co., Ltd., Tianfu International Bio-Town","place":["Chengdu, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sound Biopharmaceuticals Co., Ltd., Tianfu International Bio-Town","place":["Chengdu, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lantu","family":"Gou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Sound Biopharmaceuticals Co., Ltd., Tianfu International Bio-Town","place":["Chengdu, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Sound Biopharmaceuticals Co., Ltd., Tianfu International Bio-Town","place":["Chengdu, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanxin","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Sound Biopharmaceuticals Co., Ltd., Tianfu International Bio-Town","place":["Chengdu, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.12.010"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-16-3079"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4060"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000966"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.10.004"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.6.1963"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.7.3360"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.3.771"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.82"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.06.007"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.6.2990"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802597"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069677"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00219-7"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-056168"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-13-0945"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445388"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-16-1272"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-19-2973"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2010.09.008"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-17-1922"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-18-3654"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00945"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax3160"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-21-2762"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-006704"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.20"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910450132"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2024.1427378"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.173"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1995.05040269.x"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1917-3"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.Mct-16-0825"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.34"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/antib14010007"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719117707053"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00057-9"},{"issue":"4","key":"e_1_3_6_39_1","first-page":"610","article-title":"A novel 5T4-targeting antibody-drug conjugate H6-DM4 exhibits potent therapeutic efficacy in gastrointestinal tumor xenograft models","volume":"8","author":"Wang R","year":"2018","unstructured":"Wang R , Lai Q , Tang L , Tao Y , Yao Y , Liu Y , Lu Y , Shen C , Lu R , Fan C , et al. A novel 5T4-targeting antibody-drug conjugate H6-DM4 exhibits potent therapeutic efficacy in gastrointestinal tumor xenograft models. Am J Cancer Res. 2018;8(4):610\u2013623.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02618"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.073"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003176"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130573"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000203"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.Mct-22-0395"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07136-7"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2023.2167189"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-17-1243"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.4161\/21624011.2014.970918"},{"issue":"7","key":"e_1_3_6_50_1","first-page":"3246","article-title":"A novel 4-1BB\/HER2 bispecific antibody shows potent antitumor activities by increasing and activating tumor-infiltrating T cells","volume":"13","author":"Shen A","year":"2023","unstructured":"Shen A , Liu W , Wang H , Zeng X , Wang M , Zhang D , Zhao Q , Fang Q , Wang F , Cheng L , et al. A novel 4-1BB\/HER2 bispecific antibody shows potent antitumor activities by increasing and activating tumor-infiltrating T cells. Am J Cancer Res. 2023;13(7):3246\u20133256.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.8016"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00117"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-741041"},{"key":"e_1_3_6_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2023.2205336"},{"key":"e_1_3_6_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002428"},{"key":"e_1_3_6_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27613-w"},{"key":"e_1_3_6_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/2515135518821623"}],"container-title":["OncoImmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/2162402X.2026.2684136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:16:53Z","timestamp":1781111813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/2162402X.2026.2684136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/2162402X.2026.2684136"],"URL":"https:\/\/doi.org\/10.1080\/2162402x.2026.2684136","relation":{},"ISSN":["2162-402X"],"issn-type":[{"value":"2162-402X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=koni20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=koni20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2684136"}}