{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:45:00Z","timestamp":1759063500086},"reference-count":119,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Human Vaccines &amp; Immunotherapeutics"],"published-print":{"date-parts":[[2015,9,2]]},"DOI":"10.1080\/21645515.2015.1026498","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T20:23:23Z","timestamp":1433449403000},"page":"2228-2240","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["The catalytic A1 domains of cholera toxin and heat-labile enterotoxin are potent DNA adjuvants that evoke mixed Th1\/Th17 cellular immune responses"],"prefix":"10.1080","volume":"11","author":[{"given":"Kenneth","family":"Bagley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayuko","family":"Ota-Setlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Egan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Fouts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-008-8076-3"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00269-4"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.2174\/156652311798192815"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00980.x"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.02.033"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11478"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0998-867"},{"key":"cit0008","first-page":"73","volume":"127","author":"Babiuk S","year":"2006","journal-title":"Methods Mol Med"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2.2.255"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02335-08"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00055-07"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300847"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.11.073"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.09.053"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1656(00)00308-4"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.9.4635"},{"key":"cit0017","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.4049\/jimmunol.158.5.2278","volume":"158","author":"Feltquate DM","year":"1997","journal-title":"J Immunol"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00250-5"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4536-4546.2002"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00132-4"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.03.046"},{"key":"cit0022","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1128\/JVI.71.1.169-178.1997","volume":"71","author":"Chow YH","year":"1997","journal-title":"J Virol"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1999.40.4.355"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199803)28:03%3c1089::AID-IMMU1089%3e3.0.CO;2-L"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1089\/10799900050023906"},{"key":"cit0026","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.4049\/jimmunol.162.5.2912","volume":"162","author":"Sin JI","year":"1999","journal-title":"J Immunol"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00793.x"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4730"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9109"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.633"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0905-1059"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.7.2.175"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.11.070"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.16.7485-7495.2000"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2005.21.629"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2005.21.629"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.08.024"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.10.035"},{"key":"cit0039","volume-title":"Shocking results from HVTN 080. HVTN Conference","author":"Kalams S","year":"2010"},{"key":"cit0040","author":"Bagley KC","journal-title":"Clin Vaccine Immunol"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00038-0"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2494(98)80144-2"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/133.Supplement_1.S31"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4125.656"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1021\/bi971383p"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.8.3307"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.1998.00750.x"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6276"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.10.5533-5539.2002"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.6850-6856.2003"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.7.1123"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220915"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.10.5750"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1080\/09687680410001663267"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101184200"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1038\/292413a0"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1644"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.7.1203"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1016\/S1438-4221(00)80064-8"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.6.5.809"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1038\/36014"},{"key":"cit0062","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.4049\/jimmunol.161.7.3211","volume":"161","author":"Glenn GM","year":"1998","journal-title":"J Immunol"},{"key":"cit0063","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1128\/IAI.67.3.1100-1106.1999","volume":"67","author":"Glenn GM","year":"1999","journal-title":"Infect Immun"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1038\/82225"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003789"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002348107"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005190"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00181-12"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083321"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1014"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00406-0"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6292"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01218.x"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.08.093"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.24.11598-11607.2000"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5448"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.2174\/187152809787582507"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.1.221"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00214.x"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.03.009"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.4306"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.562"},{"key":"cit0083","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.4049\/jimmunol.158.10.4591","volume":"158","author":"Iwasaki A","year":"1997","journal-title":"J Immunol"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1089\/107999099314441"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.07.017"},{"key":"cit0086","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1128\/IAI.56.7.1748-1753.1988","volume":"56","author":"Fukuta S","year":"1988","journal-title":"Infect Immun"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.11.010"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00908.x"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00044.x"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1995.tb00690.x"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01140.x"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.02.061"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.06.009"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033715"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1586\/erv.09.82"},{"key":"cit0096","first-page":"223","volume":"940","author":"Yager EJ","year":"2013","journal-title":"Methods Mol Biol"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709198104"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.12.7969"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2007.74"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1725"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2010.071"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.14.6278-6286.2000"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1038\/nature05969"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1038\/nature05970"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7310106"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12035"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009234107"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00628.x"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.08.041"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1993"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.03.011"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/12.2.173"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00338.x"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1988.4.369"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199004000-00004"}],"container-title":["Human Vaccines &amp; Immunotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21645515.2015.1026498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T04:17:11Z","timestamp":1691727431000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21645515.2015.1026498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,4]]},"references-count":119,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,6,4]]},"published-print":{"date-parts":[[2015,9,2]]}},"alternative-id":["10.1080\/21645515.2015.1026498"],"URL":"https:\/\/doi.org\/10.1080\/21645515.2015.1026498","relation":{},"ISSN":["2164-5515","2164-554X"],"issn-type":[{"value":"2164-5515","type":"print"},{"value":"2164-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}