{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:22:38Z","timestamp":1791404558066,"version":"4.3.3"},"reference-count":101,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Human Vaccines & Immunotherapeutics"],"published-print":{"date-parts":[[2017,9,2]]},"DOI":"10.1080\/21645515.2017.1316909","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T20:31:00Z","timestamp":1503693060000},"page":"1972-1988","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":302,"title":["Tocilizumab (Actemra)"],"prefix":"10.1080","volume":"13","author":[{"given":"Martin","family":"Sheppard","sequence":"first","affiliation":[{"name":"Southend University Hospital NHS Foundation Trust, Westcliff on Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faidra","family":"Laskou","sequence":"additional","affiliation":[{"name":"Southend University Hospital NHS Foundation Trust, Westcliff on Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip P.","family":"Stapleton","sequence":"additional","affiliation":[{"name":"Southend University Hospital NHS Foundation Trust, Westcliff on Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahryar","family":"Hadavi","sequence":"additional","affiliation":[{"name":"Southend University Hospital NHS Foundation Trust, Westcliff on Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Southend University Hospital NHS Foundation Trust, Westcliff on Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"cit0001","unstructured":"Assessment Report For RoActemra [Internet]. 1st ed. London: European Medicines Agency; 2009 [accessed 2017 Jan 3]. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Public_assessment_report\/human\/000955\/WC500054888.pdf"},{"key":"cit0002","unstructured":"RoACTEMRA [Internet]. F Hoffmann-La Roche Ltd; c2017 [accessed 2017 Jan 2]. http:\/\/www.roche.com\/products\/product-details.htm?productId=30d444d8-7658-469e-9fce-f4de549c00c4"},{"key":"cit0003","unstructured":"ACTEMRA [Internet]. Genentech USA; c2016 [accessed 2017 Jan 2]. http:\/\/www. actemra.com\/"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.9.1364"},{"key":"cit0005","unstructured":"RoActemra 20mg\/ml Concentrate for Solution for Infusion. Electronic Medicines Compendium; 29\/07\/16 [Updated 9\/8\/16; accessed 4\/1\/17]. Available from: https:\/\/www.medicines.org.uk\/emc\/medicine\/22311\/SPC\/RoActemra+20mg+ml+Concentrate+for+Solution+for+Infusion\/"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.012"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1002\/art.27221"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.06.019"},{"issue":"10","key":"cit0009","volume":"68","author":"Stone J","year":"2016","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091185"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1631-y"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1002\/art.10620"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1097-z"},{"key":"cit0015","unstructured":"Tocilizumab (RoActemra (EU), Actemra (US)) UKMi New Drugs Online Database [Internet]. [cited 2016 Jun 19]. Available from: http:\/\/www.ukmi.nhs.uk\/applications\/ndo\/record_view_open.asp?newDrugID = 4214"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.127"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X10378372"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560060501"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115806"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110340"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019427"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.295758"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4989"},{"key":"cit0024","author":"Honjo T","year":"2014","journal-title":"Molecular Biology of B Cells."},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1186\/ar2099"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040391"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607999200"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.2.736"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.9.1364"},{"key":"cit0030","unstructured":"Guideline for the use of intravenous tocilizumab in the treatment of adult patients with rheumatoid arthritis.pdf [Internet]. [cited 2016 Jun 19]. Available from: http:\/\/www.rheumatology.org.uk\/includes\/documents\/cm_docs\/2014\/b\/bsr_bhpr_guideline_for_the_use_of_intravenous_tocilizumab_in_the_treatment_of_adult_patients_with_rheumatoid_arthritis.pdf"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1002\/art.21394"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes113"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1007\/s13554-012-0001-6"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0985-y"},{"key":"cit0035","volume-title":"GUIDELINE ON DEVELOPMENT, PRODUCTION, CHARACTERISATION AND SPECIFICATIONS FOR MONOCLONAL ANTIBODIES AND RELATED PRODUCTS [Internet]","year":"2009","edition":"1"},{"key":"cit0036","volume-title":"ICH Topic Q 6 B Specifications: Test Procedures and Acceptance Criteria for Biotechnological\/Biological Products [Internet]","year":"1999","edition":"1"},{"key":"cit0037","volume-title":"ICH Topic Q5E Comparability of Biotechnological\/Biological products [Internet]"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2016.1145579"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1002\/art.20303"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070449"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092932"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60453-5"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105197"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1002\/art.30158"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1002\/art.23940"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203523"},{"key":"cit0047","first-page":"S1076","volume":"66","author":"Kivitz A","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02489.x"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205351"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092866"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.2147\/BTT.S101289"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-1"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141210"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120687"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0279-5"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-015-0383-8"},{"key":"cit0057","unstructured":"Actemra, Highlights of prescribing Information [Internet]. Genentech; c2013 [accessed 2017 Jan 3]. https:\/\/www.gene.com\/download\/pdf\/actemra_prescribing.pdf"},{"key":"cit0058","unstructured":"RoActemra 162\u00a0mg Solution for Injection in Pre-Filled Syringe. Electronic Medicines Compendium; 29\/07\/16 [Updated 9\/8\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/28809\/"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22110"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1129692"},{"key":"cit0061","unstructured":"Remicade 100\u00a0mg powder for concentrate for solution for infusion. Electronic Medicines Compendium; 9\/06\/16 [Updated 21\/7\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/3236"},{"key":"cit0062","unstructured":"Humira 40 mg\/0.4\u00a0ml Pre-filled Syringe and Pre-filled Pen. Electronic Medicines Compendium; 12\/12\/16 [Updated 30\/12\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/31860"},{"key":"cit0063","unstructured":"Enbrel 50\u00a0mg solution for injection in pre-filled pen. Electronic Medicines Compendium; 1\/04\/16 [Updated 6\/5\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/22143"},{"key":"cit0064","unstructured":"Simponi 100\u00a0mg solution for injection. Electronic Medicines Compendium; 13\/10\/16 [Updated 11\/11\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/28316"},{"key":"cit0065","unstructured":"Cimzia 200\u00a0mg solution for injection in pre-filled syringe. Electronic Medicines Compendium; 01\/12\/16 [Updated 20\/12\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/22323"},{"key":"cit0066","unstructured":"Mabthera 100\u00a0mg and 500\u00a0mg Concentrate for Solution for Infusion. Electronic Medicines Compendium; 26\/05\/16 [Updated 8\/6\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/2570"},{"key":"cit0067","unstructured":"Kineret 100\u00a0mg solution for injection in a pre-filled syringe. Electronic Medicines Compendium; 28\/01\/16 [Updated 31\/03\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/23104"},{"key":"cit0068","unstructured":"ORENCIA 250\u00a0mg powder for concentrate for solution for infusion. Electronic Medicines Compendium; 01\/08\/16 [Updated 1\/9\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/19714"},{"key":"cit0069","unstructured":"Ilaris 150\u00a0mg powder for solution for injection. Electronic Medicines Compendium; 1\/08\/16 [Updated 10\/8\/16; accessed 4\/1\/17]. Available from: http:\/\/www.medicines.org.uk\/emc\/medicine\/22718"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(87)90170-0"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2005.01.001"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60250-0"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200822050-00004"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.2.2.11271"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev404"},{"key":"cit0076","unstructured":"RoActemra 162\u00a0mg Solution for Injection in Pre-Filled Syringe. Electronic Medicines Compendium; 29\/07\/16 [Updated 9\/8\/16; accessed 5\/1\/17]. Available from: https:\/\/www.medicines.org.uk\/emc\/medicine\/28809"},{"key":"cit0077","unstructured":"ORENCIA 125\u00a0mg solution for injection (pre-filled syringe). Electronic Medicines Compendium; 01\/08\/16 [Updated 1\/9\/16; accessed 5\/1\/17]. Available from: https:\/\/www.medicines.org.uk\/emc\/medicine\/27216"},{"key":"cit0078","first-page":"93","volume":"8","author":"Huynh TK","year":"2014","journal-title":"Patient Prefer Adherence"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1002\/art.11439"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S12494"},{"issue":"10","key":"cit0081","volume":"65","author":"Leffers HCB","year":"2013","journal-title":"Arthritis Rheum"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1002\/art.27227"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2012.762037"},{"issue":"2","key":"cit0084","first-page":"CD008794","volume":"16","author":"Singh JA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1002\/art.11137"},{"issue":"3","key":"cit0086","first-page":"567","volume":"68","author":"van Vollenhoven RF","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1827-x"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130466"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201148"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.12.002"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2011.01292.x"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.132134"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.2147\/BTT.S20659"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068064"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201282"},{"key":"cit0096","first-page":"466","volume":"70","author":"Sibilia J","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21847"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/29.6.456"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5%3c1041::AID-ANR12%3e3.0.CO;2-7"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00560-2"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000137"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-eular.2727"}],"container-title":["Human Vaccines & Immunotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21645515.2017.1316909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T17:14:24Z","timestamp":1506100464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21645515.2017.1316909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,25]]},"references-count":101,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,8,25]]},"published-print":{"date-parts":[[2017,9,2]]}},"alternative-id":["10.1080\/21645515.2017.1316909"],"URL":"https:\/\/doi.org\/10.1080\/21645515.2017.1316909","relation":{},"ISSN":["2164-5515","2164-554X"],"issn-type":[{"value":"2164-5515","type":"print"},{"value":"2164-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,25]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}