{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:53:27Z","timestamp":1773021207562,"version":"3.50.1"},"reference-count":99,"publisher":"Informa UK Limited","issue":"12","funder":[{"name":"authors and required no substantial funding to be stated"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Human Vaccines & Immunotherapeutics"],"published-print":{"date-parts":[[2020,12,1]]},"DOI":"10.1080\/21645515.2020.1842034","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T17:08:42Z","timestamp":1607015322000},"page":"2913-2920","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":50,"title":["Plant-based vaccines and antibodies to combat COVID-19: current status and prospects"],"prefix":"10.1080","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7469-4752","authenticated-orcid":false,"given":"Kuldeep","family":"Dhama","sequence":"first","affiliation":[{"name":"Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthilkumar","family":"Natesan","sequence":"additional","affiliation":[{"name":"Division of Biological & Life Sciences, Indian Institute of Public Health Gandhinagar, Ganghinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-7354","authenticated-orcid":false,"given":"Mohd.","family":"Iqbal Yatoo","sequence":"additional","affiliation":[{"name":"Division of Veterinary Clinical Complex, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Alusteng Srinagar, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailesh Kumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-3472","authenticated-orcid":false,"given":"Ruchi","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4185","authenticated-orcid":false,"given":"Shailendra K","family":"Saxena","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine, King George\u2019s Medical University (KGMU), Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7630-8413","authenticated-orcid":false,"given":"Harapan","family":"Harapan","sequence":"additional","affiliation":[{"name":"Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"},{"name":"Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"},{"name":"Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.36.COVID19-S4.2638"},{"key":"cit0002","first-page":"33","author":"Dhama K","year":"2020","journal-title":"Clin Microbiol Rev"},{"key":"cit0003","first-page":"9(7):519","year":"2020","journal-title":"Pathogens"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.04.018"},{"key":"cit0005","unstructured":"CDC. 1918 Pandemic (H1N1 virus). https:\/\/wwwcdcgov\/flu\/pandemic-resources\/1918-pandemic-h1n1html (Accessed 14th July 2020) 2020."},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1735227"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.22207\/JPAM.14.1.02"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2020-0286"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1080\/2164551520201788310"},{"key":"cit0010","first-page":"15","author":"Ciotti M","year":"2020","journal-title":"Crit Rev Clin Lab Sci"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400470"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319310003"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2020.05.014"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1038\/342076a0"},{"key":"cit0015","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nbt1106-1301","volume":"24","author":"Vermij P","year":"2006","journal-title":"Nat Biotechnol"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4928637"},{"key":"cit0017","first-page":"275","volume":"10","author":"Naderi S","year":"2015","journal-title":"Res J Fish Hydrobiol"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00512-0"},{"key":"cit0019","first-page":"2015:936940","author":"Liew PS","year":"2015","journal-title":"Adv Virol"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3008-1_3"},{"key":"cit0021","first-page":"1","volume":"1","year":"2013","journal-title":"J Exp Biol Agric Sci"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2019.00720"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2020.04.009"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2020.107519"},{"key":"cit0025","first-page":"9(2):148","author":"Shanmugaraj B","year":"2020","journal-title":"Pathogens"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-019-00222-1"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00428-6"},{"key":"cit0028","first-page":"56","volume":"4","author":"William S","year":"2002","journal-title":"J Young Invest"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2020.05.004"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-050213-035850"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.4161\/hv.7.3.14266"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800172-1.00001-X"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-020-02560-w"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90123-2"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0390-217"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.11.023"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.3390\/v4113227"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.10.017"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.08.003"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1586\/erv.10.79"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1711.2005.01341.x"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12796"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1038\/nature13777"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2005.00159.x"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200900111"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2017.07.019"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2010.00521.x"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5488"},{"key":"cit0049","first-page":"5(2):14","year":"2017","journal-title":"Vaccines (Basel)"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1007\/BF02686007"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2006.00191.x"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1007\/s11248-007-9135-6"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2006.05.024"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1007\/s11816-007-0012-9"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2020.101755"},{"key":"cit0056","first-page":"21(9): 3377","author":"Prete M","year":"2020","journal-title":"Int J Mol Sci"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.037"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2123"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1788310"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.3201\/eid1107.050219"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-0170-0"},{"key":"cit0063","first-page":"12(2):135","author":"Gralinski LE","year":"2020","journal-title":"Viruses"},{"key":"cit0064","first-page":"94(7):e00127\u201320","author":"Wan Y","year":"2020","journal-title":"J Virol"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.03.002"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0385-z"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0426-7"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2090"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.4161\/hv.6.2.9899"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.05.073"},{"key":"cit0071","unstructured":"British American Tobacco. BAT working on potential COVID-19 vaccine through US bio-tech subsidiary. https:\/\/wwwbatcom\/group\/sites\/UK__9D9KCYnsf\/vwPagesWebLive\/DOBN8QNL (Accessed 1 July 2020) 2020."},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1739565"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M300048-MCP200"},{"key":"cit0075","unstructured":"Anon. British and American Tobacco Company. Potential COVID-19 vaccine \u2013 BAT in the news. 2020. [accessed 2020 Oct 4]. https:\/\/www.bat.com\/group\/sites\/UK__9D9KCY.nsf\/vwPagesWebLive\/DOBNHBWR"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105955"},{"key":"cit0077","first-page":"8(2):183","author":"Rosales-Mendoza S","year":"2020","journal-title":"Vaccines (Basel)"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25159"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1587"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2009.00496.x"},{"key":"cit0081","unstructured":"Phillip Morris International. Medicago develops a plant-based vaccine for Coronavirus. 2020. (Accessed 1 July 2020). https:\/\/wwwpmicom\/media-center\/news\/medicago-develops-a-plant-based-vaccine-for-coronavirus"},{"key":"cit0082","unstructured":"iBio. iBio announces development of proprietary COVID-19 vaccine candidates. 2020. https:\/\/wwwglobenewswirecom\/news-release\/2020\/03\/18\/2002546\/0\/en\/iBio-Announces-Development-of-Proprietary-COVID-19-Vaccine-Candidateshtml (Accessed 1 July 2020)"},{"key":"cit0083","unstructured":"ISAAA. Native australian plant paves way for vaccine development against COVID-19. 2020. http:\/\/wwwisaaaorg\/kc\/cropbiotechupdate\/article\/defaultasp?ID=18054 (Accessed 1 July 2020)"},{"key":"cit0084","doi-asserted-by":"crossref","unstructured":"ISAAA. Nanoengineers combine molecular farming and advanced manufacturing to develop COVID-19 vaccine. 2020. http:\/\/wwwisaaaorg\/kc\/cropbiotechupdate\/article\/defaultasp?ID=18090 (Aceessed: 1 July 2020)","DOI":"10.5185\/vpoam.2020.0822"},{"key":"cit0085","unstructured":"WHO. DRAFT landscape of COVID-19 candidate vaccines \u2013 18 June 2020. 2020. https:\/\/wwwwhoint\/docs\/default-source\/coronaviruse\/novel-coronavirus-landscape-covid-19f65d59aff81049f5a50d37bebf0caf93pdf?sfvrsn=394d10c9_2%26download (Accessed 7 July 2020)"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.12.8266-8274.2005"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2009.03.006"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0832472100"},{"key":"cit0089","first-page":"83","volume":"14","author":"Fischer R","year":"2000","journal-title":"J Biol Regul Homeost Agents"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.130266ad"},{"key":"cit0091","first-page":"55","volume":"332","author":"Ko K","year":"2009","journal-title":"Curr Top Microbiol Immunol"},{"key":"cit0092","first-page":"10","volume":"38","author":"Shanmugaraj B","year":"2020","journal-title":"Asian Pac J Allergy Immunol"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004168117"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4783"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.7774\/cevr.2015.4.1.17"},{"key":"cit0096","unstructured":"Kuchler H, Mancini D WHO and Roche launch trials of potential coronavirus treatments. 2020. https:\/\/wwwswissinfoch\/eng\/covid-19_who-and-roche-launch-trials-of-potential-coronavirus-treatments\/45630498 (Accessed: 1 July 2020)"},{"key":"cit0097","unstructured":"Solnik C Northwell health initiates clinical trials of 2 COVID-19 drugs. 2020. https:\/\/wwwlongislandpresscom\/2020\/03\/21\/northwell-health-initiates-clinical-trials-of-2-covid-19-drugs\/ (Accessed: 1 July 2020)"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1021\/bi00742a032"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.09.006"}],"container-title":["Human Vaccines & Immunotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21645515.2020.1842034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T19:16:52Z","timestamp":1631906212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21645515.2020.1842034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":99,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["10.1080\/21645515.2020.1842034"],"URL":"https:\/\/doi.org\/10.1080\/21645515.2020.1842034","relation":{},"ISSN":["2164-5515","2164-554X"],"issn-type":[{"value":"2164-5515","type":"print"},{"value":"2164-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}