{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:59:11Z","timestamp":1792785551030,"version":"4.5.0"},"reference-count":87,"publisher":"Informa UK Limited","issue":"5","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/"}],"funder":[{"name":"Sanford Endowment intramural funds","award":["312028-1.00-61517"],"award-info":[{"award-number":["312028-1.00-61517"]}]},{"name":"Military Infectious Diseases Research Program","award":["F0600_20_NM"],"award-info":[{"award-number":["F0600_20_NM"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Collaborative Health Initiative Research Program","award":["NHLBIIAAA-A-HL-007.001"],"award-info":[{"award-number":["NHLBIIAAA-A-HL-007.001"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Human Vaccines & Immunotherapeutics"],"published-print":{"date-parts":[[2022,11,30]]},"DOI":"10.1080\/21645515.2022.2048622","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T09:49:27Z","timestamp":1648547367000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":18,"title":["Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2R\u03b3cKO.NOD) for COVID-19"],"prefix":"10.1080","volume":"18","author":[{"given":"Teodor-D.","family":"Brumeanu","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Vir","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Faisal","family":"Karim","sequence":"additional","affiliation":[{"name":"Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swagata","family":"Kar","sequence":"additional","affiliation":[{"name":"Bioqual Inc, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Benetiene","sequence":"additional","affiliation":[{"name":"Bioqual Inc, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Lok","sequence":"additional","affiliation":[{"name":"Bioqual Inc, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Greenhouse","sequence":"additional","affiliation":[{"name":"Bioqual Inc, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Putmon-Taylor","sequence":"additional","affiliation":[{"name":"Bioqual Inc, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kitajewski","sequence":"additional","affiliation":[{"name":"Bioqual Inc, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K.","family":"Chung","sequence":"additional","affiliation":[{"name":"Bioqual Inc, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-6133","authenticated-orcid":false,"given":"Kathleen P.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Bioqual Inc, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia A.","family":"Casares","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA"},{"name":"Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01315"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06801-0"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2008-3"},{"key":"e_1_3_6_6_1","unstructured":"WHO. (2021). https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019."},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2020.04.007"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30937-5"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.031"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14134"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006000"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2762"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2179-y"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_3_6_16_1","unstructured":"Draft landscape of COVID-19 candidate vaccines. WHO. September 2020. https:\/\/www.who.int\/publications\/m\/item\/draft-landscape-of-covid-19-candidate-vaccines."},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1932"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.008"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.11.054"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.070525997"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2607-z"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31208-3"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31604-4"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.07.018"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.26.221861"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.15.098079"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i39.6159"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.09.16.300970"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022483"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2639-4"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.08.17.20176651"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01844"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.10.15.20209817"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2286-9"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.714175"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-678247\/v1"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.03.17.20200246"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02012-06"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01702-06"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00737-08"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-020-00272-6"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.10.007"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2016.08.006"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019826"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28093"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-386"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01405"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2264-y"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00816"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1713605"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1403703"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.10.006"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00819-21"},{"key":"e_1_3_6_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00851-6"},{"key":"e_1_3_6_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501702"},{"key":"e_1_3_6_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016245"},{"key":"e_1_3_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.08.017"},{"key":"e_1_3_6_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600941549"},{"key":"e_1_3_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2020.102485"},{"key":"e_1_3_6_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0259"},{"key":"e_1_3_6_61_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2396fje"},{"key":"e_1_3_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/81326"},{"key":"e_1_3_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.062"},{"key":"e_1_3_6_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00152"},{"key":"e_1_3_6_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0348-8"},{"key":"e_1_3_6_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601896"},{"key":"e_1_3_6_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.659339"},{"key":"e_1_3_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110015"},{"key":"e_1_3_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110148"},{"key":"e_1_3_6_70_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmh.jmh_287_20"},{"key":"e_1_3_6_71_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2020.35.e86"},{"key":"e_1_3_6_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab153"},{"key":"e_1_3_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(20)30172-5"},{"key":"e_1_3_6_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftaa026"},{"key":"e_1_3_6_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14201"},{"key":"e_1_3_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30076-X"},{"key":"e_1_3_6_77_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051365"},{"key":"e_1_3_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.09.013"},{"key":"e_1_3_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.011"},{"key":"e_1_3_6_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.369.6505.752"},{"key":"e_1_3_6_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2548-6"},{"key":"e_1_3_6_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.017"},{"key":"e_1_3_6_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2550-z"},{"key":"e_1_3_6_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-014-9428-3"},{"key":"e_1_3_6_85_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6175964"},{"key":"e_1_3_6_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420997"},{"key":"e_1_3_6_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00182-17"},{"key":"e_1_3_6_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01155-4"}],"container-title":["Human Vaccines & Immunotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21645515.2022.2048622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T16:21:28Z","timestamp":1707150088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21645515.2022.2048622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":87,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11,30]]}},"alternative-id":["10.1080\/21645515.2022.2048622"],"URL":"https:\/\/doi.org\/10.1080\/21645515.2022.2048622","relation":{},"ISSN":["2164-5515","2164-554X"],"issn-type":[{"value":"2164-5515","type":"print"},{"value":"2164-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,29]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2048622"}}