{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:57:18Z","timestamp":1793361438845,"version":"4.5.0"},"reference-count":45,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["C615300504062"],"award-info":[{"award-number":["C615300504062"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Caiyun Postdoctoral Program in Yunnan Province of China","award":["202401BF070001-020"],"award-info":[{"award-number":["202401BF070001-020"]}]},{"name":"Yunnan Fundamental Research Project"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Human Vaccines & Immunotherapeutics"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/21645515.2025.2610068","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:29:42Z","timestamp":1769772582000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Development of a unified mass cytometry assay integrating activation-induced markers (AIMs) and cytokine profiling for high-throughput assessment of antigen-specific T cell responses"],"prefix":"10.1080","volume":"22","author":[{"given":"Na","family":"Wan","sequence":"first","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]},{"name":"Southwest United Graduate School","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Xue","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sifan","family":"Chen","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houze","family":"Yu","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xupu","family":"Ma","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]},{"name":"Southwest United Graduate School","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]},{"name":"Yunnan Vaccine Laboratory","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie Scott","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]},{"name":"Southwest United Graduate School","place":["Kunming, China"]},{"name":"Yunnan Vaccine Laboratory","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]},{"name":"Yunnan Vaccine Laboratory","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing Medical University","place":["Nanjing, China"]},{"name":"Jiangsu Provincial Center for Disease Control and Prevention (Jiangsu Provincial Academy of Preventive Medicine)","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-7068","authenticated-orcid":false,"given":"Yanli","family":"Chen","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1127470"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41434-020-00214-w"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.268"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crimmu.2022.08.004"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13622"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02144.x"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2023.100690"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12636"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24377-1"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab159"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.157031"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04085-y"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh1823"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.08.001"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI152379"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100727"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26137-7"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00794-9"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines6030050"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1528-1"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.23162"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142956.cy0631s55"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.46439\/signaling.2.041"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.05.022"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abd2071"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-025-01772-2"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.9.2.243-250.2001"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(99)00010-1"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186998"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2317"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.020"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402661"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22640"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2023.113584"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200638"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab471"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28743"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.01.015"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2007.05.011"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167215"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.24543"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2016.02.002"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28791-2"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22778"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1004415"}],"container-title":["Human Vaccines & Immunotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21645515.2025.2610068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:29:42Z","timestamp":1769772582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21645515.2025.2610068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/21645515.2025.2610068"],"URL":"https:\/\/doi.org\/10.1080\/21645515.2025.2610068","relation":{},"ISSN":["2164-5515","2164-554X"],"issn-type":[{"value":"2164-5515","type":"print"},{"value":"2164-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=khvi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2610068"}}