{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:36:00Z","timestamp":1793140560384,"version":"4.5.0"},"reference-count":15,"publisher":"Informa UK Limited","issue":"sup1","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"],"published-print":{"date-parts":[[2017,10,31]]},"DOI":"10.1080\/21678421.2017.1362440","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T17:20:08Z","timestamp":1504632008000},"page":"71-79","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":20,"title":["A safety analysis of edaravone (MCI-186) during the first six cycles (24 weeks) of amyotrophic lateral sclerosis (ALS) therapy from the double-blind period in three randomized, placebo-controlled studies"],"prefix":"10.1080","volume":"18","author":[{"given":"Alexander","family":"Kalin","sequence":"first","affiliation":[{"name":"Mitsubishi Tanabe Pharma Development America, Inc, Jersey City, NJ, USA, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvia","family":"Medina-Paraiso","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Development America, Inc, Jersey City, NJ, USA, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kim","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Development America, Inc, Jersey City, NJ, USA, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Development America, Inc, Jersey City, NJ, USA, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Saita","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Development America, Inc, Jersey City, NJ, USA, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Wasaki","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61156-7"},{"key":"CIT0002","doi-asserted-by":"crossref","unstructured":"Rascovsky K, Xie S, Boller A, Han X, McCluskey L, Elman L, et\u00a0al. Subscales of the ALS functional rating scale (ALSFRS-R) as determinants of survival in amyotrophic lateral sclerosis (ALS). Poster session presented at: Anterior Horn Cell Disease, Biomarker. 66th Annual meeting of American Academy of Neurology: 2014 April 27-May 2; Philadelphia, PA.","DOI":"10.1212\/WNL.82.10_supplement.P4.094"},{"key":"CIT0003","doi-asserted-by":"crossref","unstructured":"Rudnicki S, Al-Lahham T, Gundogdu B, Limaye K, Mahuwala Z, Williams H. Is worse prognosis in older ALS patients more than just a matter of years? Poster session presented at: ALS Imaging, Biomarkers, and Clinical Testing. 67th Annual meeting of American Academy of Neurology: 2015 April 18\u201324; Washington, DC.","DOI":"10.1212\/WNL.84.14_supplement.P6.103"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1159\/000380855"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131965"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.3109\/17482960802566824"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0022-3565(25)38652-0","volume":"268","author":"Watanabe T","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00490-3"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(97)00311-X"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.10.026"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002813"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1080\/17482960600881870"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.959024"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30115-1"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1361441"}],"container-title":["Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21678421.2017.1362440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21678421.2017.1362440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T15:46:23Z","timestamp":1750866383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21678421.2017.1362440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":15,"journal-issue":{"issue":"sup1","published-online":{"date-parts":[[2017,9,5]]},"published-print":{"date-parts":[[2017,10,31]]}},"alternative-id":["10.1080\/21678421.2017.1362440"],"URL":"https:\/\/doi.org\/10.1080\/21678421.2017.1362440","relation":{},"ISSN":["2167-8421","2167-9223"],"issn-type":[{"value":"2167-8421","type":"print"},{"value":"2167-9223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iafd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iafd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}