{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:59:47Z","timestamp":1780498787384,"version":"3.54.1"},"reference-count":295,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico","doi-asserted-by":"crossref","award":["305981\/2023\u20134"],"award-info":[{"award-number":["305981\/2023\u20134"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI164968"],"award-info":[{"award-number":["AI164968"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK084195"],"award-info":[{"award-number":["DK084195"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR083247"],"award-info":[{"award-number":["AR083247"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lupus Research Foundation"},{"DOI":"10.13039\/100012051","name":"Lupus Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Precision Medicine and Drug Development"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/23808993.2025.2560307","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:05:36Z","timestamp":1760958336000},"page":"34-55","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Towards precision medicine for systemic lupus erythematosus and neuropsychiatric manifestations"],"prefix":"10.1080","volume":"10","author":[{"given":"Bruna","family":"Martins de Aquino","sequence":"first","affiliation":[{"name":"University of Campinas","place":["Campinas, Brazil"]},{"name":"University of Campinas","place":["Campinas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u03afs Nitsch","family":"Mazzola","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Campinas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Rog\u00e9rio","family":"Julio","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Campinas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Marchi Silva","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Campinas, Brazil"]},{"name":"University of Campinas","place":["Campinas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara Rosa","family":"Sepresse","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Campinas, Brazil"]},{"name":"University of Campinas","place":["Campinas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Brett","family":"Niewold","sequence":"additional","affiliation":[{"name":"Department of Medicine","place":["New York, USA"]},{"name":"Department of Medicine","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5075-4474","authenticated-orcid":false,"given":"Simone","family":"Appenzeller","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Campinas, Brazil"]},{"name":"University of Campinas","place":["Campinas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60128-8"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.01.007"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45070378"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000001008"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0369-4"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1865156"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2019.1564040"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00138"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081133"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000822"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.04.005"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)45:5<419::AID-ART360>3.0.CO;2-X"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015546"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.01.020"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2025.103756"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216150"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2024-001490"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae119"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8060-z"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479319"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316673151"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39680"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38852"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103390"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-024-03457-1"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319887793"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307084723"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh646"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320961466"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.11.008"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12030355"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead221"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39653"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15070824"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-statistics-030718-105251"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2019.06.002"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/437282"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S205079"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00722-z"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.116"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5045248"},{"issue":"3","key":"e_1_3_5_46_1","first-page":"414","article-title":"One year in review 2015: systemic lupus erythematosus","volume":"33","author":"Mirabelli G","year":"2015","unstructured":"Mirabelli G, Cannarile F, Bruni C, et al. One year in review 2015: systemic lupus erythematosus. Clin Exp Rheumatol. 2015;33(3):414\u2013425.","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"e_1_3_5_47_1","first-page":"781","article-title":"Neuroinflammation in systemic lupus erythematosus - a review","volume":"60","author":"B\u0103rbulescu AL","year":"2019","unstructured":"B\u0103rbulescu AL, Sandu RE, Vreju AF, et al. Neuroinflammation in systemic lupus erythematosus - a review. Rom J Morphol Embryol Rev Roum Morphol Embryol. 2019;60(3):781\u2013786.","journal-title":"Rom J Morphol Embryol Rev Roum Morphol Embryol"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.04.008"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.148"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-014-1193-3"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.08.008"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030498"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608397104"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.12.007"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102592"},{"issue":"5","key":"e_1_3_5_56_1","first-page":"732","article-title":"Brain pathology in systemic lupus erythematosus","volume":"19","author":"Hanly JG","year":"1992","unstructured":"Hanly JG, Walsh NM, Sangalang V. Brain pathology in systemic lupus erythematosus. J Rheumatol. 1992;19(5):732\u2013741.","journal-title":"J Rheumatol"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27458"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2024.2330387"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2023.578166"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00867-y"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00230"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10205"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00085-X"},{"issue":"4","key":"e_1_3_5_64_1","first-page":"610","article-title":"Cognitive and neurologic deficits in the MRL\/lpr mouse: a clinicopathologic study","volume":"20","author":"Hess DC","year":"1993","unstructured":"Hess DC, Taormina M, Thompson J, et al. Cognitive and neurologic deficits in the MRL\/lpr mouse: a clinicopathologic study. J Rheumatol. 1993;20(4):610\u2013617.","journal-title":"J Rheumatol"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxad010"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370617"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223506"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu501oa"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00230-3"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu503oa"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6232-5"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218004"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac343"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.12.004"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.10.003"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.110"},{"issue":"3","key":"e_1_3_5_77_1","first-page":"171","article-title":"Neuropsychiatric manifestations associated with anti-endothelial cell antibodies in systemic lupus erythematosus","volume":"17","author":"Perricone C","year":"2015","unstructured":"Perricone C, Pendolino M, Olivieri M, et al. Neuropsychiatric manifestations associated with anti-endothelial cell antibodies in systemic lupus erythematosus. Isr Med Assoc J IMAJ. 2015;17(3):171\u2013178.","journal-title":"Isr Med Assoc J IMAJ"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2015.12.006"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510055103"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.011"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22031"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-107"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14432"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.520"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00487"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42252"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5047898"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318804895"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071285"},{"key":"e_1_3_5_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.10.010"},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.2.99"},{"key":"e_1_3_5_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2008.12.002"},{"key":"e_1_3_5_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312451201"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0471-9"},{"key":"e_1_3_5_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1326751"},{"key":"e_1_3_5_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316688784"},{"key":"e_1_3_5_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-014-0440-9"},{"key":"e_1_3_5_98_1","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.306"},{"key":"e_1_3_5_99_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2023-0833"},{"key":"e_1_3_5_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.12.008"},{"key":"e_1_3_5_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350310"},{"key":"e_1_3_5_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20999"},{"key":"e_1_3_5_103_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.3528"},{"key":"e_1_3_5_104_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223035"},{"key":"e_1_3_5_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2240959"},{"key":"e_1_3_5_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.598665"},{"key":"e_1_3_5_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000411"},{"key":"e_1_3_5_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000084"},{"key":"e_1_3_5_109_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200463"},{"key":"e_1_3_5_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34571"},{"key":"e_1_3_5_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26051851"},{"key":"e_1_3_5_112_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150884"},{"key":"e_1_3_5_113_1","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2022.8769"},{"key":"e_1_3_5_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2011.49"},{"key":"e_1_3_5_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-019-0801-5"},{"key":"e_1_3_5_116_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.210363"},{"key":"e_1_3_5_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1444885"},{"key":"e_1_3_5_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.11.033"},{"key":"e_1_3_5_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-025-01910-2"},{"key":"e_1_3_5_120_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114157"},{"key":"e_1_3_5_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.73"},{"key":"e_1_3_5_122_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201760"},{"key":"e_1_3_5_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202351"},{"key":"e_1_3_5_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02496"},{"key":"e_1_3_5_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2022.108953"},{"key":"e_1_3_5_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-018-4048-7"},{"key":"e_1_3_5_127_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033221076733"},{"key":"e_1_3_5_128_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.220513"},{"key":"e_1_3_5_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-024-05696-0"},{"key":"e_1_3_5_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(19)30142-0"},{"key":"e_1_3_5_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00647"},{"key":"e_1_3_5_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-018-01966-7"},{"key":"e_1_3_5_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-019-0349-y"},{"key":"e_1_3_5_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-12-S1-P116"},{"key":"e_1_3_5_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40158"},{"key":"e_1_3_5_136_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac275"},{"key":"e_1_3_5_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-022-00722-6"},{"key":"e_1_3_5_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev436"},{"key":"e_1_3_5_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-019-00627-2"},{"key":"e_1_3_5_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14826"},{"key":"e_1_3_5_141_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033241255011"},{"key":"e_1_3_5_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2091"},{"key":"e_1_3_5_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36887"},{"key":"e_1_3_5_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-016-0245-x"},{"key":"e_1_3_5_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.04.014"},{"key":"e_1_3_5_146_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2022040477"},{"key":"e_1_3_5_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01019-1"},{"key":"e_1_3_5_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42416"},{"key":"e_1_3_5_149_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79100"},{"key":"e_1_3_5_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04642-z"},{"key":"e_1_3_5_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.07.019"},{"key":"e_1_3_5_152_1","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2022.9167"},{"key":"e_1_3_5_153_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211004"},{"key":"e_1_3_5_154_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0781"},{"key":"e_1_3_5_155_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001492"},{"key":"e_1_3_5_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.063"},{"key":"e_1_3_5_157_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221080"},{"issue":"4","key":"e_1_3_5_158_1","first-page":"556","article-title":"Noonan syndrome and systemic lupus erythematosus in a patient with a novel KRAS mutation","volume":"28","author":"Leventopoulos G","year":"2010","unstructured":"Leventopoulos G, Denayer E, Makrythanasis P, et al. Noonan syndrome and systemic lupus erythematosus in a patient with a novel KRAS mutation. Clin Exp rheumatol. 2010;28(4):556\u2013557.","journal-title":"Clin Exp rheumatol"},{"key":"e_1_3_5_159_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020232"},{"key":"e_1_3_5_160_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015329"},{"key":"e_1_3_5_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.04.009"},{"key":"e_1_3_5_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199909)42:9<1833::AID-ANR7>3.0.CO;2-Q"},{"key":"e_1_3_5_163_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118892"},{"key":"e_1_3_5_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-019-00695-4"},{"key":"e_1_3_5_165_1","doi-asserted-by":"crossref","unstructured":"Barnabei L Lamrini H Castela M et al. Heterozygous RELA mutations cause early-onset systemic lupus erythematosus by hijacking the NF-\u03baB pathway towards transcriptional activation of type-I interferon genes. bioRxiv. 2020;2020.04.27.046102.","DOI":"10.1101\/2020.04.27.046102"},{"key":"e_1_3_5_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18925-4"},{"key":"e_1_3_5_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2265-1"},{"key":"e_1_3_5_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10242-9"},{"key":"e_1_3_5_169_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216410"},{"key":"e_1_3_5_170_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-18"},{"key":"e_1_3_5_171_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222795"},{"key":"e_1_3_5_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1404-2"},{"key":"e_1_3_5_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2022.110332"},{"key":"e_1_3_5_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/75963"},{"key":"e_1_3_5_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.10.008"},{"key":"e_1_3_5_176_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907609"},{"key":"e_1_3_5_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00774-4"},{"key":"e_1_3_5_178_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.931179"},{"key":"e_1_3_5_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2024.101975"},{"key":"e_1_3_5_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2011.10.007"},{"key":"e_1_3_5_181_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu381xx"},{"issue":"10","key":"e_1_3_5_182_1","first-page":"1477","article-title":"Rheumatic diseases in Alaskan Indians of the southeast coast: high prevalence of rheumatoid arthritis and systemic lupus erythematosus","volume":"18","author":"Boyer GS","year":"1991","unstructured":"Boyer GS, Templin DW, Lanier AP. Rheumatic diseases in Alaskan Indians of the southeast coast: high prevalence of rheumatoid arthritis and systemic lupus erythematosus. J rheumatol. 1991;18(10):1477\u20131484.","journal-title":"J rheumatol"},{"key":"e_1_3_5_183_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080912"},{"key":"e_1_3_5_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.09.004"},{"key":"e_1_3_5_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.05.041"},{"key":"e_1_3_5_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40290-017-0178-6"},{"key":"e_1_3_5_187_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu158oa"},{"key":"e_1_3_5_188_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu451xx"},{"key":"e_1_3_5_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23578"},{"key":"e_1_3_5_190_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000104742.42401.e2"},{"key":"e_1_3_5_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23416"},{"key":"e_1_3_5_192_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313502571"},{"key":"e_1_3_5_193_1","doi-asserted-by":"publisher","DOI":"10.1191\/9612332lu155oa"},{"key":"e_1_3_5_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34650"},{"key":"e_1_3_5_195_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390160099020"},{"issue":"10","key":"e_1_3_5_196_1","first-page":"1990","article-title":"Ethnic variation in disease patterns and health outcomes in systemic lupus erythematosus","volume":"33","author":"Johnson SR","year":"2006","unstructured":"Johnson SR, Urowitz MB, Iba\u00f1ez D, et al. Ethnic variation in disease patterns and health outcomes in systemic lupus erythematosus. J rheumatol. 2006;33(10):1990\u20131995.","journal-title":"J rheumatol"},{"key":"e_1_3_5_197_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1205800"},{"key":"e_1_3_5_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.09.012"},{"key":"e_1_3_5_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22672"},{"key":"e_1_3_5_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2014.04.001"},{"key":"e_1_3_5_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364316"},{"key":"e_1_3_5_202_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111467"},{"key":"e_1_3_5_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30598"},{"key":"e_1_3_5_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34483"},{"key":"e_1_3_5_205_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/17vmqc"},{"key":"e_1_3_5_206_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803917"},{"key":"e_1_3_5_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(02)00767-5"},{"key":"e_1_3_5_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.10.010"},{"key":"e_1_3_5_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.12.008"},{"key":"e_1_3_5_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.01.005"},{"key":"e_1_3_5_211_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2014.915393"},{"key":"e_1_3_5_212_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707628104"},{"key":"e_1_3_5_213_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.60.10"},{"key":"e_1_3_5_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.07.005"},{"key":"e_1_3_5_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.012"},{"key":"e_1_3_5_216_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310389100"},{"issue":"10","key":"e_1_3_5_217_1","first-page":"19701","article-title":"A correlation study on the effects of DNMT1 on methylation levels in CD4(+) T cells of SLE patients","volume":"8","author":"Liang J","year":"2015","unstructured":"Liang J, Zhu X-H, Qin H-H, et al. A correlation study on the effects of DNMT1 on methylation levels in CD4(+) T cells of SLE patients. Int J Clin Exp Med. 2015;8(10):19701\u201319708.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_5_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2023.103089"},{"key":"e_1_3_5_219_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10833"},{"key":"e_1_3_5_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.29"},{"key":"e_1_3_5_221_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2015-000101"},{"key":"e_1_3_5_222_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2008.00739.x"},{"key":"e_1_3_5_223_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2013.826207"},{"key":"e_1_3_5_224_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802412"},{"key":"e_1_3_5_225_1","doi-asserted-by":"publisher","DOI":"10.1139\/O10-112"},{"key":"e_1_3_5_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.12.012"},{"key":"e_1_3_5_227_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001727"},{"key":"e_1_3_5_228_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930802024129"},{"key":"e_1_3_5_229_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1604607"},{"key":"e_1_3_5_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.66"},{"key":"e_1_3_5_231_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/740619"},{"key":"e_1_3_5_232_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0294-2"},{"key":"e_1_3_5_233_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142307"},{"key":"e_1_3_5_234_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.299313"},{"key":"e_1_3_5_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.08.009"},{"key":"e_1_3_5_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.05.022"},{"key":"e_1_3_5_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22646"},{"key":"e_1_3_5_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_3_5_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03049"},{"key":"e_1_3_5_240_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.142"},{"key":"e_1_3_5_241_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.699684"},{"key":"e_1_3_5_242_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27632"},{"key":"e_1_3_5_243_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24436"},{"key":"e_1_3_5_244_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904060"},{"key":"e_1_3_5_245_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20090"},{"key":"e_1_3_5_246_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00418"},{"key":"e_1_3_5_247_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.37.032807.125908"},{"key":"e_1_3_5_248_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3154"},{"key":"e_1_3_5_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2016.11.001"},{"key":"e_1_3_5_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0288-3"},{"key":"e_1_3_5_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.009"},{"key":"e_1_3_5_252_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00342"},{"key":"e_1_3_5_253_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00319"},{"key":"e_1_3_5_254_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.998328"},{"key":"e_1_3_5_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.03.018"},{"key":"e_1_3_5_256_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0023-4"},{"key":"e_1_3_5_257_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0156-8"},{"key":"e_1_3_5_258_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215089"},{"key":"e_1_3_5_259_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224762"},{"key":"e_1_3_5_260_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13817"},{"key":"e_1_3_5_261_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-021-00457-z"},{"key":"e_1_3_5_262_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-004171"},{"key":"e_1_3_5_263_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092163"},{"key":"e_1_3_5_264_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0887-378X.2004.00327.x"},{"key":"e_1_3_5_265_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001180"},{"key":"e_1_3_5_266_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30613"},{"key":"e_1_3_5_267_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912196"},{"key":"e_1_3_5_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(19)30076-1"},{"key":"e_1_3_5_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00578-X"},{"key":"e_1_3_5_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.02.005"},{"key":"e_1_3_5_271_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2023-0086"},{"key":"e_1_3_5_272_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41811"},{"key":"e_1_3_5_273_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42652"},{"key":"e_1_3_5_274_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220920"},{"key":"e_1_3_5_275_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42557"},{"key":"e_1_3_5_276_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab381"},{"key":"e_1_3_5_277_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2106535"},{"key":"e_1_3_5_278_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216379"},{"key":"e_1_3_5_279_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41598"},{"key":"e_1_3_5_280_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32167-6"},{"key":"e_1_3_5_281_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001511"},{"key":"e_1_3_5_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2022.100152"},{"key":"e_1_3_5_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02546-6"},{"key":"e_1_3_5_284_1","doi-asserted-by":"publisher","DOI":"10.1002\/ART.42926"},{"key":"e_1_3_5_285_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27601"},{"key":"e_1_3_5_286_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224854"},{"key":"e_1_3_5_287_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42391"},{"issue":"11","key":"e_1_3_5_288_1","first-page":"2156","article-title":"Neuropsychiatric events in systemic lupus erythematosus: attribution and clinical significance","volume":"31","author":"Hanly JG","year":"2004","unstructured":"Hanly JG, McCurdy G, Fougere L, et al. Neuropsychiatric events in systemic lupus erythematosus: attribution and clinical significance. J rheumatol. 2004;31(11):2156\u20132162.","journal-title":"J rheumatol"},{"key":"e_1_3_5_289_1","doi-asserted-by":"publisher","DOI":"10.2165\/11591670-000000000-00000"},{"key":"e_1_3_5_290_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025528"},{"key":"e_1_3_5_291_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315622821"},{"key":"e_1_3_5_292_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11174955"},{"key":"e_1_3_5_293_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144178.32208.4F"},{"key":"e_1_3_5_294_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.057885"},{"key":"e_1_3_5_295_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3775-6"},{"key":"e_1_3_5_296_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.8.960"},{"key":"e_1_3_5_297_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2870::AID-ART475>3.0.CO;2-Y"}],"container-title":["Expert Review of Precision Medicine and Drug Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/23808993.2025.2560307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T11:13:35Z","timestamp":1765365215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/23808993.2025.2560307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":295,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/23808993.2025.2560307"],"URL":"https:\/\/doi.org\/10.1080\/23808993.2025.2560307","relation":{},"ISSN":["2380-8993"],"issn-type":[{"value":"2380-8993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tepm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tepm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}