{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:29:42Z","timestamp":1791088182692,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T00:00:00Z","timestamp":1200614400000},"content-version":"vor","delay-in-days":3123,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>alpha\u2010Tocopherol plays an important role as a lipid\u2010soluble antioxidant. It is present in all major mammalian cell types and shows tissue\u2010specific distribution. This suggests the presence of specific proteins involved in intracellular distribution or metabolism of alpha\u2010tocopherol. A diminution of tocopherol plasma concentrations contributes to the development of diseases such as vitamin E deficiency (AVED), atherosclerosis, and prostate cancer. Further evidence has been obtained for the existence of sites in cellular metabolism and signal transduction where alpha\u2010tocopherol potentially plays a regulatory role. A signal transduction modulation specific for alpha\u2010tocopherol has been described in several model systems. Using radioactively labeled alpha\u2010tocopherol as tracer, we have isolated a new alpha\u2010tocopherol\u2010associated protein (TAP) from bovine liver. This protein has a molecular mass of 46 kDa and an isoelectric point of 8.1. From its partial amino acid sequence, a human gene has been identified with high homology to the newly described protein. Sequence analysis has established that the new TAP has structural motifs suggesting its belonging to a family of hydrophobic ligand\u2010binding proteins (RALBP, CRALBP,alpha\u2010TTP, SEC 14, PTN 9, RSEC 45). Human TAP has been cloned into Escherichia coli, and its tissue\u2010specific expression has been assessed by Northern blot analysis.<\/jats:p>","DOI":"10.1080\/713803478","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T11:48:21Z","timestamp":1183808901000},"page":"49-55","source":"Crossref","is-referenced-by-count":57,"title":["Identification of a Novel Cytosolic Tocopherol\u2010Binding Protein: Structure, Specificity, and Tissue Distribution"],"prefix":"10.1002","volume":"48","author":[{"given":"Achim","family":"Stocker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan E.","family":"Spycher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Azzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,18]]},"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F713803478","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/713803478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T07:56:31Z","timestamp":1698566191000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1080\/713803478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1080\/713803478"],"URL":"https:\/\/doi.org\/10.1080\/713803478","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}