{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:47:39Z","timestamp":1757702859235},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":609,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To examine the effect of smoking on the incidence of low\u2010 and high\u2010grade cervical intraepithelial neoplasia (CIN) in women with a baseline Pap smear of atypical squamous cells (ASC) or a low\u2010grade squamous intraepithelial lesion (LSIL). <jats:italic>Design<\/jats:italic>. Prospective study in which a cohort of women with normal colposcopy and ASC\/LSIL at baseline were followed at 6\u2010month intervals of up to 36 months. Women were grouped in post\u2010hoc analysis according to their smoking behavior: never (or past) smokers and current smokers. <jats:italic>Setting<\/jats:italic>. This report was based on data from the Latin American Screening Study, conducted in S\u00e3o Paulo, Campinas, Porto Alegre (Brazil) and Buenos Aires (Argentina). <jats:italic>Population<\/jats:italic>. A subset of 150 women derived from a cohort of 1,011 women. <jats:italic>Methods<\/jats:italic>. Multivariate Cox analysis and Kaplan\u2013Meier curves were used. <jats:italic>Main outcome measures<\/jats:italic>. Low\u2010 and high\u2010grade CIN during follow\u2010up. <jats:italic>Results<\/jats:italic>. The only factor related to an increased risk of developing CIN was the positive high\u2010risk (hr) HPV status (hazard ratio (HR) = 3.42; 95% CI: 1.11\u20139.43). A total of 21 cases of incident CIN were detected during follow\u2010up. Of these, 11 appeared in the group of 67 smokers and 10 among the 83 non\u2010smoker women (log\u2010rank, <jats:italic>p<\/jats:italic> = 0.33). Smoking status was not associated with the risk of developing CIN (HR = 0.73; 95% CI: 0.40\u20131.33). However, when restricting the analysis to high\u2010grade CIN only (11 cases), the probability of developing the disease was significantly higher among smokers (<jats:italic>p<\/jats:italic> = 0.04). <jats:italic>Conclusions<\/jats:italic>. Smoking contributes additional risk for developing high\u2010grade CIN in women with ASC or LSIL cytology but normal colposcopy.<\/jats:p>","DOI":"10.1080\/00016340902846072","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T03:48:44Z","timestamp":1237866524000},"page":"514-520","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Smoking worsens the prognosis of mild abnormalities in cervical cytology"],"prefix":"10.1111","volume":"88","author":[{"given":"RENATA","family":"GUARISI","sequence":"first","affiliation":[]},{"given":"LUIS OTAVIO","family":"SARIAN","sequence":"additional","affiliation":[]},{"given":"LUCIANO SERPA","family":"HAMMES","sequence":"additional","affiliation":[]},{"given":"ADHEMAR","family":"LONGATTO\u2010FILHO","sequence":"additional","affiliation":[]},{"given":"SOPHIE F.M.","family":"DERCHAIN","sequence":"additional","affiliation":[]},{"given":"CEC\u00cdLIA","family":"ROTELI\u2010MARTINS","sequence":"additional","affiliation":[]},{"given":"PAULO","family":"NAUD","sequence":"additional","affiliation":[]},{"given":"MOJCA","family":"ER\u017dEN","sequence":"additional","affiliation":[]},{"given":"MARGHERITA","family":"BRANCA","sequence":"additional","affiliation":[]},{"given":"S\u00cdLVIO","family":"TATTI","sequence":"additional","affiliation":[]},{"given":"SILVANO","family":"COSTA","sequence":"additional","affiliation":[]},{"given":"STINA","family":"SYRJ\u00c4NEN","sequence":"additional","affiliation":[]},{"given":"JOANA F.","family":"BRAGAN\u00c7A","sequence":"additional","affiliation":[]},{"given":"KARI","family":"SYRJ\u00c4NEN","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003477"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000003811.98261.3e"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.12.868"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00203-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.461"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.456"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.02.047"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981029)78:3<281::AID-IJC3>3.0.CO;2-R"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.09.054"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000292372"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000292280"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910230504"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0918"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.3.205"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0577"},{"key":"e_1_2_6_17_2","first-page":"3469","article-title":"Comparing PAP smear cytology, aided visual inspection, screening colposcopy, cervicography and HPV testing as optional screening tools in Latin America. 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