{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:20:28Z","timestamp":1772713228278,"version":"3.50.1"},"reference-count":112,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Reviews in Toxicology"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1080\/10408440091159211","type":"journal-article","created":{"date-parts":[[2005,8,23]],"date-time":"2005-08-23T14:49:25Z","timestamp":1124808565000},"page":"287-306","source":"Crossref","is-referenced-by-count":11,"title":["Heterologous Expression of Xenobiotic Mammalian-Metabolizing Enzymes in Mutagenicity Tester Bacteria: An Update and Practical Considerations"],"prefix":"10.1080","volume":"30","author":[{"given":"Michel","family":"Kranendonk","sequence":"first","affiliation":[{"name":"Department of Genetics, Faculty of Medical Sciences, Universidade Nova de Lisboa, R. da Junqueira 96, 1349-008, Lisbon, Portugal"}]},{"given":"Ant\u00f3nio","family":"Laires","sequence":"additional","affiliation":[{"name":"Leiden\/Amsterdam Center for Drug Research (LACDR) Division of Molecular Toxicology, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands"}]},{"given":"Jos\u00e9","family":"Rueff","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Medical Sciences, Universidade Nova de Lisboa, R. da Junqueira 96, 1349-008, Lisbon, Portugal"}]},{"given":"Ronald W.","family":"Estabrook","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235, Texas"}]},{"given":"Nico P. E.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Technology, Universidade Nova de Lisboa, 2825-114 Monte de Caparica, Portugal"}]}],"member":"301","published-online":{"date-parts":[[2008,9,29]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(92)90050-A"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602539409029789"},{"key":"e_1_2_1_4_1","first-page":"29","volume-title":"Cytochrome P450: Metabolic and Toxicological Aspects","author":"Vermeulen N. P. E.","year":"1996","unstructured":"Vermeulen, N. P. E. 1996. Role of metabolism in chemi- cal toxicity. In: C. Ioannides, (Ed.) Cytochrome P450: Metabolic and Toxicological Aspects, CRC Press, Boca Raton, FL, pp. 29\u201353"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810515)47:10<2327::AID-CNCR2820471003>3.0.CO;2-Z"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(92)90047-D"},{"key":"e_1_2_1_7_1","first-page":"69","volume-title":"The Predictive Value of Short-Term Screening Tests in Carcinoge- nicity Evaluation","author":"Bridges J. W.","year":"1980","unstructured":"Bridges, J. W. and Hubbard, S. A. 1980. Problems in providing an appropriate drug metabolizing system for short-term tests for carcinogens. In: The Predictive Value of Short-Term Screening Tests in Carcinoge- nicity Evaluation, G. M. Wialliams, R. Kroes, H. W. Waaijers, and K. W. van de Poll, Elsevier, Amsterdam, pp. 69\u201388."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(95)00246-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(91)90039-Q"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"Simula A. P. Crichton M. B. Black S. M. Pemble S. Bligh H. F. J. Beggs J. D. and Wolf C. R. 1993. Heterologous experession of drug-metabolizing enzymes in cellular and whole animal models. Toxicol- ogy 82: 3\u201320.","DOI":"10.1016\/0300-483X(93)90056-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408449609037477"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(96)00041-5"},{"key":"e_1_2_1_13_1","first-page":"5457","article-title":"Genotoxicity of aflatoxin B1:","volume":"56","author":"Sengstag C.","year":"1996","unstructured":"Sengstag, C., Werbel, B. and Fasullo, M. 1996. Genotoxicity of aflatoxin B1: evidence for recombi- nation-mediated mechanism in S. cerevisiae. Cancer Res. 56: 5457\u20135465.","journal-title":"evidence for recombi- nation-mediated mechanism in S. cerevisiae. Cancer Res."},{"key":"e_1_2_1_14_1","first-page":"313","article-title":"Search for cell culture with diverse xenobiotic-metabolizing activi- ties and their use in toxicology studies","volume":"1","author":"Glatt H. R.","year":"1987","unstructured":"Glatt, H. R. and Gemperlein, I. 1987. Search for cell culture with diverse xenobiotic-metabolizing activi- ties and their use in toxicology studies. Mol. Toxicol. 1, 313\u2013334.","journal-title":"Mol. Toxicol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.002101"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90264-Q"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(93)90007-D"},{"key":"e_1_2_1_18_1","first-page":"143","volume-title":"IARC Scientific Publications","author":"Venitt S.","year":"1986","unstructured":"Venitt, S., Bartsch, H., Becking, G., Fuchs, R. P. P., Hofnung, M., Malaveille, C., Matsushima, T., Rajewsky, M. R., Roberfroid, M., and Rosenkranz, H. S. 1986. Short-term assays using bacteria. In: Long- Term and Short-Term Assays for Carcinogens: A Critical Appraisal. IARC Scientific Publications, no. 83, Lyon, Chap. 5, Oxford University Press, Oxford, UK, pp. 143\u2013156."},{"key":"e_1_2_1_19_1","first-page":"2946","article-title":"Roles of cytochrome P450 en- zymes in chemical carcinogens and cancer chemo- therapy","volume":"48","author":"Guengerich F. P.","year":"1988","unstructured":"Guengerich, F. P. 1988. Roles of cytochrome P450 en- zymes in chemical carcinogens and cancer chemo- therapy. Cancer Res. 48: 2946\u20132954.","journal-title":"Cancer Res"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.9.5312-5325.1990"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.8.2525-2538.1992"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-3-642-79528-2_16","volume-title":"Molecular Aspects of Oxidative Drug Metabolizing Enzymes","author":"Anderson D.","year":"1995","unstructured":"Anderson, D. 1995. Genotoxicity assays. In: Molecular Aspects of Oxidative Drug Metabolizing Enzymes. Arin\u00e7, E., Schenkman, J. B., and Hodgson, E., Eds., NATO ASI Series, Vol. H90, Springer-Verlag, Ber- lin, pp. 303\u2013396."},{"key":"e_1_2_1_23_1","unstructured":"Friedberg E. C. Walker G. C. and Siede W. 1995. DNA Repair and Mutagenesis ASM Press Washing- ton DC pp. 407\u2013464."},{"key":"e_1_2_1_24_1","first-page":"465","volume-title":"DNA Repair and Mutagenesis","author":"Friedberg E. C.","year":"1995","unstructured":"Friedberg, E. C., Walker, G. C., and Siede, W. 1995. DNA Repair and Mutagenesis, ASM Press, Washing- ton, DC, pp. 465\u2013522."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.145.3.1310-1316.1981"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.21.6844-6851.1992"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00259396"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(85)90053-6"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(83)90010-9"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(85)90020-2"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(85)90062-7"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029810"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/13.3.263"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408449991349186"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(97)00133-6"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(97)00068-9"},{"key":"e_1_2_1_37_1","first-page":"710","article-title":"Genetic polymorphism and cancer susceptibility: fourteenth Sapporo cancer seminar","volume":"55","author":"Gonzalez F.","year":"1995","unstructured":"Gonzalez, F. 1995. Genetic polymorphism and cancer susceptibility: fourteenth Sapporo cancer seminar. Cancer Res., 55: 710\u2013715.","journal-title":"Cancer Res."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02353478"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(98)00005-2"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0897-784"},{"key":"e_1_2_1_41_1","first-page":"2523","volume-title":"Activation","author":"Shimada T.","year":"1994","unstructured":"Shimada, T., Gillam, E. M. J., Sandhu, P., Guo, Z., Tukey, R. H., and Guengerich, F. P. 1994. Activation of procarcinogens by human cytochrome P450 en- zymes expressed in Escherichia coli. Simplified bac- terial systems for genotoxocity assays. Carcinogen- esis 15: 2523\u20132529."},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.9.2167"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0031-6997(25)06846-2","article-title":"Enzymes and transport systems in- volved in the formation and disposition of glutathione- S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics","volume":"47","author":"Commandeur J. N. M.","year":"1995","unstructured":"Commandeur, J. N. M., Stijntjes, G. J., and Vermeulen, N. P. E. 1995. Enzymes and transport systems in- volved in the formation and disposition of glutathione- S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics. Pharmacol. Rev. 47: 271\u2013 330.","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602539808996325"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8576"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.2.297"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx950125v"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx00045a019"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.7.1371"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.11.2303"},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","unstructured":"Thier R. Pemble S. E. Kramer H. Taylor J. B. Guengerich F. P. and Ketterer B. 1996. Human glutathione-S-transferase T1-1 enhances mutagenic- ity of 1 2-dibromoethane and 1 2 3 4-diepoxybutane in Salmonella typhimurium. <i>Carcinogenesis17: 163\u2013166.","DOI":"10.1093\/carcin\/17.1.163"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(89)90036-3"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602539409029806"},{"key":"e_1_2_1_54_1","first-page":"3961","article-title":"Salmonella typhimurium strains express- ing human arylamine N-acetyltransferases: metabo- lism and mutagenic activation of aromatic amines","volume":"52","author":"Grant D. M.","year":"1992","unstructured":"Grant, D. M., Josephy, P. D., Lord, H. L., and Morrison, L. D. 1992. Salmonella typhimurium strains express- ing human arylamine N-acetyltransferases: metabo- lism and mutagenic activation of aromatic amines. Cancer Res. 52: 3961\u20133964.","journal-title":"Cancer Res"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(87)80165-1"},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","unstructured":"Wild D. Feser W. Michel S. Lord H. L. and Josephy D. 1995. Metabolic activation of heterocyclic aro- matic amines catalyzed by human arylamine N- acetyltransferase isoenzymes (NAT1 and NAT2) ex- pressed in Salmonellla typhimurium. <i>Carcinogenesis16: 643\u2013648.","DOI":"10.1093\/carcin\/16.3.643"},{"key":"e_1_2_1_57_1","first-page":"799","article-title":"Bioactivation of aromatic amines by recom- binant human cytochrome P4501A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations","volume":"55","author":"Josephy D. P.","year":"1995","unstructured":"Josephy, D. P., Debruin, L. S., Lord, H. L., Oak, J. N., Evans, D. H., Guo, Z., Dong, M., and Guengerich, F. 1995. Bioactivation of aromatic amines by recom- binant human cytochrome P4501A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations. Cancer Res., 55: 799\u2013 802.","journal-title":"Cancer Res."},{"key":"e_1_2_1_58_1","first-page":"70","article-title":"Metabolic activation of aromatic amine mutagens by simultaneous expression of human cyto- chrome P450 1A2, NADPH cytochrome P450 reduc- tase and N-acetyltransferase in","volume":"11","author":"Josephy P. D.","year":"1998","unstructured":"Josephy, P. D., Evans, D. H., Parikh, A., and Guengerich, F. P. 1998. Metabolic activation of aromatic amine mutagens by simultaneous expression of human cyto- chrome P450 1A2, NADPH cytochrome P450 reduc- tase and N-acetyltransferase in Escherichia coli. Chem. <i>Res. Toxicol. 11: 70\u201374.","journal-title":"."},{"key":"e_1_2_1_59_1","first-page":"1833","article-title":"Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocylic amines","volume":"58","author":"Suzuki A.","year":"1998","unstructured":"Suzuki, A., Kushida, H., Iwata, H., Watanabe, M., Nohmi, T., Fujita, K., Gonzalez, F. J., and Kamataki, T. 1998. Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocylic amines. Cancer Res. 58: 1833\u20131838.","journal-title":"Cancer Res"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(98)00193-4"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)46999-2"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi973076p"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(94)90014-0"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/11.4.327"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(99)00032-7"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.5.9141497"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(94)90074-4"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(94)90073-6"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/15.1.39"},{"key":"e_1_2_1_70_1","first-page":"1519","article-title":"Metabolic activation of the carcinogen 6- hydroxymethybenzo[a]pyrene:","volume":"10","author":"Surh Y-J.","year":"1989","unstructured":"Surh, Y-J., Liem, A., Miller, E. C. and Miller, J. A. 1989. Metabolic activation of the carcinogen 6- hydroxymethybenzo[a]pyrene: formation of an elec- trophilic sulfuric acid ester and benzylic DNA ad- ducts in rat liver in vivo and in reactions in vitro. Carcinogenesis 10: 1519\u20131528.","journal-title":"formation of an elec- trophilic sulfuric acid ester and benzylic DNA ad- ducts in rat liver in vivo and in reactions in vitro. Carcinogenesis"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.2.1537466"},{"key":"e_1_2_1_72_1","first-page":"741","volume-title":"Cyto- chrome P450, Biochemistry, Biophysics and Molecular Biology","author":"Kranendonk M.","year":"1994","unstructured":"Kranendonk, M., Ruas, M., Laires, A., and Rueff, J. 1994. Isolation and prevalidation of an Escherichia coli tester strain for genotoxins. In: Lechner M. C., Ed. Cyto- chrome P450, Biochemistry, Biophysics and Molecular Biology, Jonny Libbey Eurotext, Paris, pp. 741\u2013744."},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422916"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(87)90111-1"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)72003-7"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0265"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)83274-4"},{"key":"e_1_2_1_78_1","first-page":"473","article-title":"Purification and characterization of a catalytically active human liver UDP-glucuronosyltransferase expressed as a fusion protein in E. coli. Biochem Biophys.","volume":"196","author":"Pillot T.","year":"1993","unstructured":"Pillot, T., Ouzinne, M., Fournel-Gigleux, S., Lafaurie, C., Radominska, A., Lester, R., Drake, R., Treat, S., Siest, G., and Magdalou, J. 1993. Purification and characterization of a catalytically active human liver UDP-glucuronosyltransferase expressed as a fusion protein in E. coli. Biochem Biophys. Res. Comm. 196: 473\u2013479.","journal-title":"Res. Comm."},{"key":"e_1_2_1_79_1","doi-asserted-by":"crossref","unstructured":"Kier L. E. Brusick D. J. Auketta A. E. Von Halle E. S. Brown M. M. Simmon V. F. Dunkel V. McCann J. Moertelmans K. Prival M. Roa T. K. and Ray V. 1986. The Salmonella typhimurium\/mammalian mi- crosomal assay. A report of the US Environmental Protection Agency Gene-Tox Program. Mutat.Res. 168: 69\u2013240.","DOI":"10.1016\/0165-1110(86)90002-3"},{"key":"e_1_2_1_80_1","doi-asserted-by":"crossref","unstructured":"MacPhee D. G. 1989. Development of bacterial mutage- nicity tests: a view form afar. Environ. Molec. Mu- tagen. 14 (Suppl.) 16: 35\u201338.","DOI":"10.1002\/em.2850140609"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.18.5604-5611.1991"},{"key":"e_1_2_1_82_1","first-page":"249","volume-title":"Chem. Biol. Interact","author":"Hagen M.","year":"1998","unstructured":"Hagen, M., Pabel., U., Landsiedel, R., Bartsch, I., Falany,C N., and Glatt, H. 1998. Expression of human estro- gen sulfotransferase in Salmonella typhimurium: dif- ferences between hHST and hEST in the enantioselective activation of 1-hydroxyethylpyrene to a mutagen. Chem. Biol. Interact. 109: 249\u2013253."},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/0958-1669(91)90077-I"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(85)90112-5"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.22.6929"},{"key":"e_1_2_1_86_1","volume-title":"Mo- lecular Cloning: A Laboratory Manual","author":"Sambrook J.","year":"1989","unstructured":"Sambrook, J., Fritsch, T. F., and Maniatis, T. 1989. Mo- lecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.","edition":"2"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(78)90002-7"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(89)90029-X"},{"key":"e_1_2_1_89_1","first-page":"237","article-title":"The basis of the insensitivity of Salmonella typhimurium strain TA98\/1,8-DNP to the mutagenic action of nitroarenes. Mutat. Res. 121: 17\u201323. Prieto-Alamo, M. J., Abril, N., and Pueyo, C. 1993. Mutagenesis in Escherichia coli K12 mutants defec- tive in superoxide dismutase or catalase","volume":"14","author":"McCoy E. C.","year":"1983","unstructured":"McCoy, E. C., Anders, M., and Rosenkranz, H. S. 1983. The basis of the insensitivity of Salmonella typhimurium strain TA98\/1,8-DNP to the mutagenic action of nitroarenes. Mutat. Res. 121: 17\u201323. Prieto-Alamo, M. J., Abril, N., and Pueyo, C. 1993. Mutagenesis in Escherichia coli K12 mutants defec- tive in superoxide dismutase or catalase. Carcinogen- esis 14: 237\u2013244.","journal-title":"Carcinogen- esis"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(89)90007-1"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/12.4.245"},{"key":"e_1_2_1_92_1","first-page":"1672","article-title":"New sublines of Chinese hamster CHL stably expressing human NAT1 and NAT2 N-acetyltransferases or Sal- monella typhimurium O-acetyltransferase: compari- son of the sensitivity to nitroarenes and aromatic amines using the in vitro micronucleus test","volume":"54","author":"Watanabe B.","year":"1994","unstructured":"Watanabe, B., Matsuoka, A., Yamazaki, N., Hayashi, M., Deguchi, T., Nohmi, T., and Sofuni, T. 1994. New sublines of Chinese hamster CHL stably expressing human NAT1 and NAT2 N-acetyltransferases or Sal- monella typhimurium O-acetyltransferase: compari- son of the sensitivity to nitroarenes and aromatic amines using the in vitro micronucleus test. Cancer Res. 54: 1672\u20131677.","journal-title":"Cancer Res"},{"key":"e_1_2_1_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.1.115"},{"key":"e_1_2_1_94_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1016"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(24)15017-9"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1192"},{"key":"e_1_2_1_97_1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0090-9556(24)15020-9","article-title":"Rapid characterization of the major drug-metabolizing hu- man hepatic cytochrome P450 enzymes expressed in Escherichia coli. Drug Metab.","volume":"27","author":"McGinnity D. F.","year":"1999","unstructured":"McGinnity D. F., Griffin, S. J., Moody, G. C., Voice, M., Hanlon, S., Friedberg, T., and Riley, R. J. 1999. Rapid characterization of the major drug-metabolizing hu- man hepatic cytochrome P450 enzymes expressed in Escherichia coli. Drug Metab. Dispos. 27: 1017\u20131023.","journal-title":"Dispos"},{"key":"e_1_2_1_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(96)00419-X"},{"key":"e_1_2_1_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5266.1266"},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85377-2"},{"key":"e_1_2_1_101_1","doi-asserted-by":"crossref","unstructured":"Bell P. A. and Kasper C. B. 1993. Expression of rat microsomal epoxide hydrolase in Escherichia coli. J.Biol.Chem. 268: 14011\u201314017.","DOI":"10.1016\/S0021-9258(19)85202-X"},{"key":"e_1_2_1_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53379-2"},{"key":"e_1_2_1_103_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1250"},{"key":"e_1_2_1_104_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1163"},{"key":"e_1_2_1_105_1","first-page":"20102","article-title":"Expression and characterization of a modified flavin- containing monooxygenase 4 from humans","volume":"271","author":"Itagaki K.","year":"1996","unstructured":"Itagaki, K., Craver, G. T. and Philpot, R. M. 1996. Expression and characterization of a modified flavin- containing monooxygenase 4 from humans. J. Biol. Chem. 271, 20102\u201320107. Falls, J. G., Cherrington, N. J., Clements, K. M., Philpot, R. M., Levi, P. E., Rose, R. L., and Hodgson, E. 1997. Molecular cloning, sequencing and expression in Es- cherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): comparison with the hu- man isoform. Arch. Biochem. Biophys. 347: 9\u201318.","journal-title":"Arch. Biochem. Biophys."},{"key":"e_1_2_1_106_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2840855"},{"key":"e_1_2_1_107_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0026-895X(25)08603-1","article-title":"Catalytic properties of NAD(P)H: quinoneacceptor oxidoreductase: study involving mouse, rat, human and mouse-rat chimeric enzymes","volume":"47","author":"Chen S.","year":"1995","unstructured":"Chen, S., Knox, R., Lewis, A. D., Friedlos, F., Work- man, P., Deng, P. S. K., Fung, M., Ebenstein, D. Wu, K., and Tsai, T-M. 1995. Catalytic properties of NAD(P)H: quinoneacceptor oxidoreductase: study involving mouse, rat, human and mouse-rat chimeric enzymes. Molec. Pharmacol. 47: 934\u2013939.","journal-title":"Molec. Pharmacol."},{"key":"e_1_2_1_108_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0344"},{"key":"e_1_2_1_109_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1157"},{"key":"e_1_2_1_110_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106365"},{"key":"e_1_2_1_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi990142"},{"key":"e_1_2_1_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(84)90067-8"},{"key":"e_1_2_1_113_1","first-page":"45","volume-title":"Mutagenicity Testing, A Pratical","author":"Venitt S.","year":"1984","unstructured":"Venitt, S., Crofton-Sleigh, C., and Forrester, R. 1984. Bacterial mutation assays using reverse mutation. In: Venitt, S. and Parry, J.M., Eds., Mutagenicity Testing, A Pratical Approach. Chap. 3, Oxford, IRL Press, pp. 45\u201398."}],"container-title":["Critical Reviews in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10408440091159211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:26:18Z","timestamp":1772709978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10408440091159211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":112,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1080\/10408440091159211"],"URL":"https:\/\/doi.org\/10.1080\/10408440091159211","relation":{},"ISSN":["1040-8444","1547-6898"],"issn-type":[{"value":"1040-8444","type":"print"},{"value":"1547-6898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}