{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:45:54Z","timestamp":1777491954370,"version":"3.51.4"},"reference-count":138,"publisher":"Informa UK Limited","issue":"5","funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Toxicology"],"published-print":{"date-parts":[[2019,5,28]]},"DOI":"10.1080\/10408444.2019.1626801","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T16:04:11Z","timestamp":1562169851000},"page":"411-429","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":85,"title":["<i>Caenorhabditis elegans<\/i>as a tool for environmental risk assessment: emerging and promising applications for a \u201cnobelized worm\u201d"],"prefix":"10.1080","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4887-3188","authenticated-orcid":false,"given":"L.","family":"Queir\u00f3s","sequence":"first","affiliation":[{"name":"Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7573-6184","authenticated-orcid":false,"given":"J. L.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9326-187X","authenticated-orcid":false,"given":"F. J. M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-9643","authenticated-orcid":false,"given":"M.","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-1656","authenticated-orcid":false,"given":"M.","family":"Aschner","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-0635","authenticated-orcid":false,"given":"P.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal;"}]}],"member":"301","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00038"},{"key":"CIT0002","first-page":"4298","volume":"7","author":"Alt\u0131ndag A","year":"2008","journal-title":"Afr J Biotechnol"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-012-1004-2"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-011-0804-0"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620200419"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1897\/03-264"},{"key":"CIT0007","unstructured":"ASTM International. 2014. Standard guide for conducting laboratory soil toxicity tests with the nematodeCaenorhabditis elegans. ASTM E2172-01. West Conshohocken, PA: ASTM International."},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.11.005"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.07.011"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.02.008"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1021\/cr800536y"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2014.04.024"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-014-3921-5"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1007\/BF02987727"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2806"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5347(98)01583-3"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620200714"},{"key":"CIT0019","first-page":"225","volume":"1381","author":"Boyd WA","year":"2000","journal-title":"Environ Toxicol Risk Assess Recent Achiev Environ Fate Transp"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2008.12.004"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620220518"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1897\/02-573"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","volume":"77","author":"Brenner S","year":"1974","journal-title":"Genetics"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3706"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2018.01.002"},{"key":"CIT0028","first-page":"1","volume":"40","author":"Caswell-Chen EP","year":"2005","journal-title":"Sci Aging Knowl Environ"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00018"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620190823"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.09.013"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1039\/C6EN00095A"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03984.x"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2011.07.032"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.01.145"},{"key":"CIT0037","first-page":"0","volume":"07","author":"Destefani A","year":"2017","journal-title":"J Clin Exp Dermatol Res"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1897\/04-560R.1"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620191228"},{"key":"CIT0040","first-page":"1","volume":"309","author":"EC","year":"2009","journal-title":"Off J Eur Union"},{"key":"CIT0042","first-page":"1","volume":"1052","author":"EFSA","year":"2009","journal-title":"EFSA J"},{"key":"CIT0043","volume":"11","author":"EFSA","year":"2013","journal-title":"EFSA J"},{"key":"CIT0044","first-page":"1","volume":"15","author":"EFSA","year":"2017","journal-title":"EFSA J"},{"key":"CIT0051","first-page":"5","author":"European Commission","year":"2006","journal-title":"Off J Eur Union"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1039\/C4TX00120F"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.12.006"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2008.05.012"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200701979"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05849"},{"key":"CIT0057","first-page":"1","author":"Fritsche E","year":"2015","journal-title":"EFSA Support Publ"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.14573\/altex.1701171"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9087245"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.12.113"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-004-0031-2"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615613114"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3482"},{"key":"CIT0064","first-page":"11","volume":"47","author":"Hagerbaumer A","year":"2015","journal-title":"J Nematol"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2006.02.017"},{"key":"CIT0066","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/dvdy.22184","volume":"239","author":"Harrington AJ","year":"2010","journal-title":"Dev Dyn"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90506-1"},{"key":"CIT0068","first-page":"1701S","volume":"59","author":"Horvitz HR","year":"1999","journal-title":"Cancer Res"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.65.881"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2007.10.017"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620181238"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1002\/etc.5620201219","volume":"20","author":"H\u00f6ss S","year":"2001","journal-title":"Environ Toxicol Chem"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2009.07.003"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/S0269-7491(02)00161-6"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2011.03.041"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.10.086"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3357"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-04251-w"},{"key":"CIT0079","unstructured":"ISO. 1999. ISO 11267. Soil quality\u2014inhibition of reproduction of Collembola (Folsomia candida) by soil pollutants. Geneva, Switzerland: International Organization for Standardization."},{"key":"CIT0080","unstructured":"ISO. 2008. ISO 17512-1 Soil quality\u2014avoidance test for determining the quality of soils and effects of chemicals on behaviour-Part 1: test with earthworms (Eisenia fetida andEisenia andrei). Geneva, Switzerland: International Organization for Standardization."},{"key":"CIT0081","unstructured":"ISO. 2010. ISO 10872 Water quality\u2014determination of the toxic effect of sediment and soil samples on growth, fertility and reproduction ofCaenorhabditis elegans(Nematoda). Geneva, Switzerland: International Organization for Standardization."},{"key":"CIT0082","first-page":"1","volume":"11","author":"Jiang Y","year":"2016","journal-title":"PLoS One"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1897\/03-49"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1897\/03-29"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2031"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160612261"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.55.796"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejsobi.2006.10.002"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2013.04.015"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.11.103"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn121"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2015.08.051"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1002\/etc.198"},{"key":"CIT0096","first-page":"1","volume":"10","author":"Lublin AL","year":"2014","journal-title":"Drug Discov Today Technol"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1897\/08-496.1"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2012.03.010"},{"key":"CIT0099","first-page":"28","volume":"47","author":"Majdi N","year":"2015","journal-title":"J Nematol"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-018-1946-0"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1139\/z65-060"},{"key":"CIT0102","first-page":"003","volume":"4","author":"Mcvey KA","year":"2012","journal-title":"J Environ Anal Toxicol"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402252"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2005.03.020"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-160"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2014.933722"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.10.024"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3937"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1007\/s002449900167"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2010.03.022"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2011.02.002"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-011-9274-7"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/45.1.61"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1093\/scipol\/sct020"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1007\/s13593-013-0151-z"},{"key":"CIT0129","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s002440010086","volume":"39","author":"Peredney CL","year":"2000","journal-title":"Arch Environ Contam Toxicol"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1080\/03601231003613625"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2014.08.053"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2017.10.042"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2016.05.012"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2005.01.077"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2005.10.006"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2007.11.007"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.05.008"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1897\/05-676R.1"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2009.12.003"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1021\/es803477u"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.116.195511"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.12.069"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.147058"},{"key":"CIT0144","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2005.08.031"},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2007.03.001"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(96)00251-2"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.1016\/0269-7491(94)90094-9"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06145.x"},{"key":"CIT0149","doi-asserted-by":"publisher","DOI":"10.1021\/es802474j"},{"key":"CIT0150","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.01.057"},{"key":"CIT0151","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.09.011"},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.48.555"},{"key":"CIT0153","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.49.28"},{"key":"CIT0154","first-page":"245","volume":"16","author":"Traunspurger W","year":"1997","journal-title":"Environ Toxicol Chem"},{"key":"CIT0156","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.03.067"},{"key":"CIT0157","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-445X(02)00017-6"},{"key":"CIT0158","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2008.11.004"},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010617-052429"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12360"},{"key":"CIT0161","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecolind.2016.12.051"},{"key":"CIT0162","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90485-9"},{"key":"CIT0163","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2017.03.005"},{"key":"CIT0164","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.04.011"},{"key":"CIT1164","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2015.10.057"}],"container-title":["Critical Reviews in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10408444.2019.1626801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T16:00:06Z","timestamp":1721491206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10408444.2019.1626801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,28]]},"references-count":138,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5,28]]}},"alternative-id":["10.1080\/10408444.2019.1626801"],"URL":"https:\/\/doi.org\/10.1080\/10408444.2019.1626801","relation":{},"ISSN":["1040-8444","1547-6898"],"issn-type":[{"value":"1040-8444","type":"print"},{"value":"1547-6898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}