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F<jats:sub>2<\/jats:sub>IP through the TP receptor stimulated eNOS (eight\u2010fold), while the oxidized LDL effect (two\u2010to five\u2010fold) was only partially prevented by SQ29.548. While LDL concentration and degree of oxidation synergistically and independent of SQ29.548 stimulated IL\u20106, F<jats:sub>2<\/jats:sub>IP had no effect. F<jats:sub>2<\/jats:sub>IP induced a modest (+50%) increase in ET\u20101. LDL, independent of concentration or degree of oxidation, stimulated (+120%) ET\u20101 production, and this effect was only partially attenuated by SQ29.548.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In microvascular endothelial cells, LDL concentration and degree of oxidation synergistically stimulate NO and IL\u20106 production, but only NO release is largely mediated by the TP receptor. LDL facilitates ET\u20101 release independent of concentration and degree of oxidation; TP\u2010receptor stimulation is only partially responsible for this effect.<\/jats:p>","DOI":"10.1080\/10739680701884765","type":"journal-article","created":{"date-parts":[[2008,6,27]],"date-time":"2008-06-27T13:26:21Z","timestamp":1214573181000},"page":"543-553","source":"Crossref","is-referenced-by-count":11,"title":["Role of Thromboxane A<sub>2<\/sub> Receptor on the Effects of Oxidized LDL on Microvascular Endothelium Nitric Oxide, Endothelin\u20101, and IL\u20106 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